Presentation of a 32-Year-Old Female Patient With Rapidly Growing Oral Squamous Cell Carcinoma: Report of a Rare Case.

In this case report, a 32-year-old female patient from Central India was reported. Her primary complaint was pain and swelling in the lower left back region of her jaw, which had been present for one month. On extraoral examination, asymmetrical facial symmetry was observed, and a 3 cm swelling was present on the left side of her face. An intraoral examination showed a reddish-pink ulceroproliferative growth on the left buccal mucosa. Under local anesthesia, an incisional biopsy was performed. A conclusive diagnosis of well-differentiated squamous cell carcinoma affecting the left buccal mucosa was made based on clinical and histopathological testing. The patient was scheduled for a follow-up appointment after being referred to the Cancer Institute for the required treatment. After three months, the patient reported to the department with extensive swelling on the left side of the face, measuring 6 cm in diameter. On intraoral examination, a more restricted mouth opening compared to the previous examination. The ulceroproliferative growth was firm and tender and exhibited continuous bleeding. As the patient delayed seeking proper care, the condition became more aggressive, and she lost her life. This case of oral squamous cell carcinoma (OSCC) in a 32-year-old female patient is rare, as men are more commonly affected by OSCC in Central India due to their higher prevalence of unhealthy practices. This case highlights the rapid progression of the disease if appropriate treatment is not initiated promptly upon diagnosis.

Pivotal Role of Ultrasonography and Radiology in Diagnosing a Case of Sialolith.

Sialolithiasis is a condition that affects the salivary glands, which commonly occurs within the body of the submandibular gland or the Wharton duct. This condition is characterised by pain in the submandibular area after meals. Conservative therapies such as duct milking and palliative care can provide positive results for small, easily accessible calculi. This report describes the results of radiographic imaging of a 43-year-old patient with pain and swelling in the submandibular region. During the extraoral examination, a 1.5 cm wide diffuse swelling was present in the left submandibular region, and the left submandibular gland was tender and firm. In addition, a solitary, tender left submandibular lymph node was observed. Intraorally, the opening of the submandibular duct was erythematous and inflamed. The patient was advised for necessary investigations, including an orthopantomogram, cone beam CT, neck ultrasound, and left submandibular gland sialography. Ultrasonography was preferred over other imaging techniques due to its non-invasive nature and high accuracy, sensitivity, and specificity in diagnosing sialolithiasis. Timely management of sialolith is critical as delayed treatment can lead to serious consequences. A conclusive diagnosis of left submandibular sialolithiasis, accompanied by sialadenitis, was made based on clinical, radiographic, and ultrasound findings.

Assessment of anterior loop of mandibular canal and its implication in implant therapy.

Context: Precise identification of anatomic structures is imperative for presurgical planning for implant installation to ensure effectiveness of procedures, especially in the region of mental foramen, and to prevent iatrogenic complications. Aims: This study aimed to assess the presence of anterior loop of mandibular canal and its approximation to the alveolar crest using cone-beam computed tomography (CBCT). Materials and Methods: CBCT scans of the patients scheduled for implant therapy in the region of mental foramen were retrospectively analyzed for the presence of anterior loop of mandibular canal. Findings were compared based upon gender and side of the mandible. Distance between the most prominent part of anterior loop of mandibular canal and the alveolar crest was measured. Results: Anterior loop of the mandibular canal was identified 66.8% of hemimandibles analyzed with the highest prevalence in the fourth decade of life. Males and females exhibited predilection toward the right and left side, respectively. The presence of anterior loop of mandibular canal is associated with reduced distance between the neurovascular bundle and alveolar crest jeopardizing the placement of standard length dental implant. Conclusion: The current study emphasizes an increased need for precise identification and preservation of anterior loop of mandibular canal in the third and fourth decades of life, especially in females.

Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.

AIM: To study the efficacy of topical curcumin mucoadhesive semisolid gel, triamcinolone acetonide/hyaluronidase mucoadhesive semisolid gel, and a combination of both in the treatment of oral submucous fibrosis (OSMF). MATERIALS AND METHODS: One hundred and twenty patients diagnosed with OSMF were randomly divided into groups I, II, and III. Each patients in groups I, II, and III was given professionally prepared mucoadhesive semisolid gel of curcumin, a combination of triamcinolone acetonide and hyaluronidase mucoadhesive semisolid gel, and a combination of all three, respectively. Patients were instructed to apply the gel thrice daily for 6 weeks on buccal mucosa bilaterally using the tip of index finger. Three parameters were evaluated at the end of each week, namely, mouth opening, burning on visual analog scale (VAS), and the color of oral mucosa on the binary scale. The results were subjected to statistical analysis. RESULTS: It was observed that the group administered the three drug combinations achieved the greatest mouth opening (mean increase 4.05 mm) as compared to the other two groups. It was observed that triamcinolone and hyaluronidase group reported reduction in burning sensation on VAS (mean difference 6) as compared to the other two groups. It was observed that group III (1% curcumin, 1% hyaluronidase and 0.1% triamcinolone acetonide combined) drug therapy showed better change in mucosa color as compared to groups I (1% curcumin) and II. CONCLUSION: Thus, we can conclude that curcumin has a therapeutic effect on patients diagnosed with OSMF. Maximum utilization and enhanced drug delivery were achieved with the help of a combination other two active drugs, namely, triamcinolone and hyaluronidase. CLINICAL SIGNIFICANCE: Curcumin role in the treatment of oral cancers and the precancer lesion is very promising.

An Unusually Large Irritation Fibroma Associated with Gingiva of Lower Left Posterior Teeth Region.

Fibroma is a benign tumor of oral cavity, with usually the tongue, gingiva, and buccal mucosa being the most common sites. Females are twice more likely to develop fibroma than males. The intraoral fibroma typically is well demarcated; and its size can vary from millimeter to few centimeters. Intraorally the growth is attached to the mucosa by means of a peduncle. Fibroma is generally slow growing, painless, smooth surface lesion and the color is slightly paler than the adjacent healthy tissue. Treatment usually requires total excision and recurrence is rare. Here we present a case of 37-year-old female patient reported to the Department of Oral Medicine and Radiology with the chief complaint of a growth in the lower left posterior teeth region 3 months earlier.