RESUMO
Two anephric patients in the course of one year erythropoietin therapy improved their anemic status without changes in Mean Arterial Blood Pressure. The discordant time course behaviour of hematocrit and blood pressure points to the importance of residual renal tissue for blood pressure to develop during erythropoietin therapy in the renoprival status.
Assuntos
Pressão Sanguínea/efeitos dos fármacos , Eritropoetina/uso terapêutico , Rim/fisiologia , Adulto , Anemia/tratamento farmacológico , Anemia/fisiopatologia , Terapia Combinada , Feminino , Glomerulosclerose Segmentar e Focal/complicações , Glomerulosclerose Segmentar e Focal/fisiopatologia , Glomerulosclerose Segmentar e Focal/terapia , Hematócrito , Humanos , Hipertensão/tratamento farmacológico , Hipertensão/fisiopatologia , Masculino , Nefrectomia , Doenças Renais Policísticas/complicações , Doenças Renais Policísticas/fisiopatologia , Doenças Renais Policísticas/terapia , Diálise Renal/efeitos adversos , Fatores de TempoRESUMO
Cell proliferation is significantly depressed in uremia; to assess the influence of PTH on it, normal lymphocytes were cultured in presence of uremic patients' serum with low or high plasma PTH levels (Group A; PTH less than 2.5 ng/ml; Group B: PTH greater than 12 ng/ml), and serum of normal subjects (Group C). Cell proliferation was lowered by serum from both groups (p A vs C less than 0.004; p B vs C less than 0.001). However, the depressing effect was more evident when group B serum was employed (p A vs B less than 0.002).
Assuntos
Citotoxinas , Linfócitos/patologia , Hormônio Paratireóideo/fisiologia , Uremia/metabolismo , Divisão Celular , Humanos , Hormônio Paratireóideo/análiseRESUMO
The role of PTH in depressing polynuclear leucocyte (PMN) phagocytosis in uremia was investigated. The hydrophobicity and phagocytic activity of normal PMN was tested in presence of uremic patients' serum with low (Group A) or high (Group B) levels of plasma PTH. The PMN phagocytic index was lowered by serum of both groups, but more in presence of Group B serum (p A vs B less than 0.002). Similarly, the contact angle of cells was affected more in presence of serum of patients with high PTH levels (p B vs A less than 0.003; p B vs C less than 0.002).
Assuntos
Citotoxinas , Neutrófilos/imunologia , Hormônio Paratireóideo/fisiologia , Fagocitose , Uremia/metabolismo , Humanos , Uremia/imunologiaAssuntos
Isoleucina/farmacologia , Leucina/farmacologia , Linfócitos/citologia , Uremia/patologia , Valina/farmacologia , Divisão Celular/efeitos dos fármacos , Células Cultivadas , Humanos , Falência Renal Crônica/patologia , Falência Renal Crônica/terapia , Linfócitos/patologia , Diálise Renal , Uremia/terapiaRESUMO
Hemoperfusion on ionic exchange resins in the therapy of diabetic keto-acidosis (DKA) coma is proposed. Resins used are strong anionic resins in mixed form able to release bicarbonates and to trap ketoanions and organic anions in a stoichiometric manner. A series of trials in open circuit are performed in order to search for a suitable mixture of resins and to establish the amounts of HCO3- and ketoanions respectively released or entrapped. Therefore, ten simulated hemoperfusions in closed circuit systems were performed, utilizing cartridges containing 1,700 g of mixed resin (9% HCO3- form and 91% Cl- form). The results indicate that all side effects of bicarbonate i.v. therapy of DKA coma are avoided because of the smooth HCO3- administration to the patient. Furthermore, a good removal of ketoanions and organic acids is obtained without changing the blood osmolality.
