[Effects of weak solutions of aldehydes on EEG changes in rats]. / Vliianie slabykh rastvorov al'degidov na izmeneniia EEG krys.

Alternations of EEG have been investigated after single intraarterial infusion of formaldehyde, glutaric aldehyde and its mixture in 50 adult male rats. The dissolved solutions of aldehydes were shown to have complicated inhibitive activity which consists of two phases. The first phase of EEG inhibition rapidly develops and it isn't very long in its duration. The second one is much more durable. Formaldehyde causes the first phase of inhibition in general, though glutaric aldehyde promotes especially the appearance of the second phase. The mixture of two aldehydes demonstrates synergic activity which is shown as significant increase of EEG inhibition as compared to individual inhibitive activity of aldehydes. The inhibitive influence of aldehydes is fully reversible, nonspecific and doesn't cause post-experimental disorders. The highest effect of brain protection from ischaemia damages coincides with development of maximum inhibition of specific brain functions during the second phase of EEG depression.

[Permeability of the blood-brain barrier to intra-arterial formaldehyde]. / O pronitsaemosti gematoéntsefalicheskogo bar'era dlia formal'degida pri ego vnutrisosudistom vvedenii.

Formaldehyde concentration was assessed in the brain, cerebrospinal liquor, arterial and venous blood of intact animals and following its intraarterial injections. It is concluded that formaldehyde is capable of penetrating through the blood-brain barrier, with the degree of permeability depending on blood formaldehyde concentration. The distribution of formaldehyde in the blood-brain-cerebrospinal liquor system suggests the presence of both protein-bound and unbound formaldehyde forms in the organism.

[Role of folic acid and its amino derivatives in the mechanism of action of low doses of formaldehyde on the organs]. / Rol' folievoi kisloty i ee aminoproizvodnykh v mekhanizme deistviia nizkikh doz formal'degida na organy.

The presence of the relationship between the content of formaldehyde and folic acid in solution and tissue has been studied. It has been demonstrated that folic acid and its amino derivatives reduce the content of formaldehyde in solution by over 50%. During the build up of the increased content of folic acids and its analogs, there takes place diminution of the content of exogenous formaldehyde in all the test organs. This was interpreted as evidence of a close interplay with folic acid metabolism as regards the mechanism of action of exogenous formaldehyde introduced with a purpose of organ conservation.