Comparison of single-dose cefotetan and multidose cefoxitin as intravenous prophylaxis in elective, open biliary tract surgery: a multicentre, double-blind, randomized study.

OBJECTIVE: To compare the safety, tolerance and prophylactic effectiveness of a single 2-g dose of cefotetan with a standard prophylactic regimen of cefoxitin in reducing the incidence of postoperative infections after elective, open biliary tract surgery. DESIGN: Multicentre, double-blind, randomized comparative study with a 4-week follow-up. SETTING: Five Canadian university centres. PARTICIPANTS: One hundred and eleven patients scheduled to undergo elective, open biliary tract surgery. INTERVENTIONS: The patients were randomly assigned to receive either cefotetan or cefoxitin in a ratio of 2:1; 76 patients received cefotetan and 35 received cefoxitin. MAIN OUTCOME MEASURES: Wound infection as defined by the Centers for Disease Control and Prevention and by clinical evaluation, adverse events and laboratory parameters. RESULTS: Two incisional wound infections were reported by patients in the cefotetan group, for an overall infection rate of 1.8% (2 of 111). No significant differences were found in the failure rate or in any other indicator of efficacy. The incidence of adverse events for cefotetan (12.6%) was not statistically different from that for cefoxitin (10.4%), and none of the 16 adverse events in the cefotetan group and 5 in the cefoxitin group was serious or severe. Only one event (rash) was possibly related to the study drugs. Several hematologic and biochemical parameters were found to be normal preoperatively and abnormal postoperatively, but no relation was found between these variations and the study drugs. These changes were mainly attributable to the operation. CONCLUSION: Cefotetan was found to be effective and comparable to cefoxitin, both in safety and in reducing the incidence of infection after elective, open biliary tract surgery.

Bile duct injury during laparoscopic cholecystectomy.

OBJECTIVE: To determine the nature of bile duct injuries during laparoscopic cholecystectomy, the treatment of these injuries and patient outcome. DESIGN: Case series review. SETTING: Two tertiary care hospitals. PATIENTS: Twenty-one patients (average age 37 years) who sustained bile duct injuries during laparoscopic cholecystectomy over a 2-year period. Two groups were analysed: patients whose injury was recognized intraoperatively (9 patients) and patients in whom it was diagnosed postoperatively (12 patients). INTERVENTIONS: Laparoscopic cholecystectomy, duct-to-duct repair over a T tube, Roux-en-Y hepaticojejunostomy, endoscopic cholangiopancreatography (ERCP), percutaneous transhepatic cholangiography (PTC). RESULTS: Misidentification of the common duct during laparoscopic cholecystectomy, resulting in accidental division or resection of a portion of the duct, and obstruction of the duct by hemoclips were the most common types of injury. Pain, jaundice and bile collections were the typical presenting features of injuries that became evident after laparoscopic cholecystectomy. ERCP and PTC accurately defined the injuries. Immediate duct-to-duct repair over a T tube was associated with a high failure rate. Twenty of the 21 patients required Roux-en-Y hepaticojejunostomy for definitive treatment. There were no deaths. CONCLUSIONS: Proper identification of the pertinent anatomy will prevent the majority of these injuries. Prompt radiographic visualization of the biliary tract is indicated in patients who have pain, jaundice and bile collections postoperatively. A hepaticojejunostomy is the procedure of choice for repair of these bile duct injuries.