Posture and performance: sitting vs. standing for security screening.

A classification of the literature on the effects of workplace posture on performance of different mental tasks showed few consistent patterns. A parallel classification of the complementary effect of performance on postural variables gave similar results. Because of a lack of data for signal detection tasks, an experiment was performed using 12 experienced security operators performing an X-ray baggage-screening task with three different workplace arrangements. The current workplace, sitting on a high chair viewing a screen placed on top of the X-ray machine, was compared to a standing workplace and a conventional desk-sitting workplace. No performance effects of workplace posture were found, although the experiment was able to measure performance effects of learning and body part discomfort effects of workplace posture. There are implications for the classification of posture and performance and for the justification of ergonomics improvements based on performance increases.

Pelvic stress fracture: assessment and risk factors.

OBJECTIVE: To discuss the case of a patient with a pelvic stress fracture and the differential considerations among patients presenting with hip and/or groin pain. FEATURES: A 42-year-old woman had hip pain after running. Initial radiograph of the pelvis was negative. Subsequent films showed a right inferior pubic ramus stress fracture. Stress fractures of the pelvis are relatively uncommon, accounting for only 1% to 2% of all stress fractures. INTERVENTION AND OUTCOME: Treatment included high-velocity, low-amplitude chiropractic manipulation, ultrasound, and stretching of the psoas and piriformis muscles. After 8 weeks, care was discontinued because the patient's hip pain had resolved. The pelvic fracture was left to heal with time. After 1 year, the patient still had delayed union of the fracture. CONCLUSION: When predisposing factors are present, such as osteoporosis and rheumatoid arthritis, pelvic stress fracture should be suspected in patients with groin or hip-area pain. However, because pelvic stress fractures are relatively rare, radiographic studies are often postponed, making diagnosis difficult.

Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum.

BACKGROUND & AIMS: Nerves have been suggested to mediate the effects of bacterial toxins in intestinal diseases. However, the mechanisms involved are unknown. This study examined endogenous substance P (SP) activation of the substance P receptor (SPR) on enteric neurons in the rat ileum after exposure to intraluminal Clostridium difficile toxin A. METHODS: After intraluminal injection of toxin A in ileal loops, tissue was examined for pathological changes by histology and for SPR activation by immunocytochemical analysis of SP-induced SPR endocytosis. RESULTS: After toxin A administration, > 70% of enteric neurons showed SPR endocytosis and became swollen with thickened dendrites. In contrast, SPRs in control rats were largely confined to the plasma membrane. Rats denervated of primary afferent fibers with neonatal capsaicin injection and animals pretreated with a nonpeptide SPR antagonist showed few endosomal SPRs, and the pathological inflammatory effects of toxin A were ablated. CONCLUSIONS: Intraluminal toxin A causes the release of SP from primary afferent neurons: this endogenous SP then acts on enteric neurons in the submucosal and myenteric plexuses. SP is the primary mediator of an axon reflex mediating neurogenic inflammation in the intestine. SPR blockade may prove to be a novel therapy used to prevent intestinal inflammation.

Characterization of the highly divergent U2 RNA homolog in the microsporidian Vairimorpha necatrix.

An RNA homologous to U2 RNA and a single copy gene encoding the RNA homolog have been characterized in the microsporidian, Vairimorpha necatrix. The RNA which is 165 nucleotides in length possesses significant similarity to U2 RNA, particularly in the 5' half of the molecule. The U2 homolog contains the highly conserved GUAGUA branch point binding sequence seen in all U2 RNAs except those of the trypanosomes. A U2 RNA sequence element implicated in a U2:U6 RNA intermolecular pairing is also present in the U2 homolog. The V. necatrix U2 RNA homolog differs at positions previously found to be invariant in U2 RNAs and appears to lack an Sm binding site sequence. The RNA can be folded into a secondary structure possessing three of the four principal stem-loops proposed for the consensus U2 RNA structure. A cis-diol containing cap structure is present at the 5' end of the U2 homolog. Unlike the cap structures seen in U-snRNAs and mRNAs it is neither 2,2,7-trimethylguanosine, gamma-monomethyl phosphate, nor 7-methylguanosine.

Magnetic resonance imaging versus computed tomography scan: accurate diagnosis of soft tissue lesions.

Due to their cost effectiveness and accessibility, computed tomography (CT) scans are being utilized when magnetic resonance imaging (MRI) appears to be the diagnostic technique of choice. Because of their availability, CT scans are still used for diagnosis of disc herniations. MRI may, however, be superior in its specificity. In taking into account the subjective complaint and orthopedic and neurological findings, a disk herniation can often be diagnosed without a CT scan or MRI. However, should the patient fail to respond to conservative care or show unusual symptoms, an MRI is indicated. This article discusses a case where MRI would be the imaging procedure of choice.

Human granulosa-luteal and cumulus cells express transforming growth factors-beta type 1 and type 2 mRNA.

Human granulosa-luteal cells and cumulus cells obtained from women undergoing in vitro fertilization and embryo transfer (IVF-ET) were examined for the presence of TGF-beta 1 and TGF-beta 2 mRNA by reverse transcription-polymerase chain reaction (RT-PCR) analysis. RT-PCR analysis revealed that both follicle cell types express mRNA for both TGF-beta subtypes. Verification of RT-PCR products was done by restriction enzyme digestion analysis. These results suggest a role(s) for TGF-beta 1 and TGF-beta 2 in the development of human granulosa-luteal cells and the oocyte-cumulus cell complex.

Effects of moderate alcohol intake in fixed or variable amounts on concentration of serum lipids and liver enzymes in healthy young men.

To assess the effects of moderate alcohol consumption on fasting serum triglyceride (TG), total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), glutamate-oxaloacetate transaminase (GOT), and gamma-glutamyl transferase (GGT) concentrations, groups of normolipidemic, nonsmoking, nonathletes who were moderate drinkers aged 21-35 y and within 10% of ideal body weight consumed 40 g ETOH/d as beer (fixed drinkers) or maintained usual drinking habits (variable drinkers) for 6 wk, then abstained from all alcohol for 3 wk. A similar group of nondrinkers served as the control group. HDL-C concentrations increased significantly during alcohol consumption and decreased during abstention to initial values in both the variable and fixed drinkers. No significant difference was found between the two drinking groups. LDL-C and TC concentrations in variable drinkers were modestly lower than those in nondrinkers but not in fixed drinkers. No significant differences were found in TG, GOT, and GGT concentrations between the groups or during alcohol consumption or abstention. This study demonstrates that consumption of alcohol in fixed or variable amounts is associated with an increase in HDL-C. This increase is not due to an induction of GGT and GOT as speculated.

Are opioid receptors involved in the bradycardiac and hypotensive action of clonidine?

Experimental evidence that supports or rejects an involvement of opioid receptors in the cardiovascular effects of clonidine was sought. In anesthetized rabbits, clonidine decreased blood pressure and heart rate. These effects were related to the clonidine dose. High doses of clonidine produced a biphasic response in blood pressure without resulting in a significant baroreflex. However, it was not difficult to produce hypotensive action of clonidine without the biphasic action using low doses of clonidine. A pretreatment of the animals with naloxone (1 mg/1 kg) prevented the hypotensive action of clonidine at low dose. This antagonistic action of naloxone against clonidine was also evident in other cardiac parameters such as heart rate and efferent sympathetic renal nerve activity. The antagonistic action was not demonstrably significant with the high doses of clonidine. The present study in normotensive anesthetized rabbits suggests that specific central interactions between opioid and adrenergic receptors can be demonstrated under defined conditions, although such interactions were reported in pathophysiologic conditions such as essential hypertension.

Psychotrope and alcohol use by women: one or two populations?

From a telephone survey of 1,673 Montreal women, all consenting psychotrope users and randomly selected controls (N = 179) then were interviewed in their homes as to psychotropic drug and alcohol use. The results presented are based on these in-depth interviews. In the first phase of the analysis, the respondents were grouped according to whether they abstained from both alcohol and psychotropes, used alcohol alone, psychotropes alone, or both. The variables that distinguished these groups were determined by use of one-way analysis of variance. Some of these factors included age, level of education, anxiety, nervous tension, depression, subjective ratings of health, and responses to emotional upset. The second series of results involved correlation procedures to determine the covariates of alcohol and psychotrope use. Most significant of these findings were that psychotrope use was associated with anxiety, depression, and nervous tension, while alcohol use was not. Further, unlike alcohol use, psychotrope use was associated with a variety of coping techniques for dealing with emotional upset. The findings were interpreted to mean that there are two distinct populations.

Psychotropic drug use by women: demographic, lifestyle, and personality correlates.

From initial telephone interviews with a random population of 1187 francophone women, 179 women participated in a further three-hour person-to-person interview focusing on the use of psychotropic medications. Psychotrope users typically were older, in poorer health, and had a lower level of education than abstainers. They showed an increased prevalence of nervousness, anxiety, depression, and restlessness. Initial contact with psychotrope use was through their general practitioners after presentation of vague and ill-defined symptoms. Psychotropic drug use was found among housewives, especially those with children, and among those unemployed but desiring work. Personality profiles of psychotrope users showed that they think of themselves as failures and are more distressed, with significantly greater life changes. Users scored higher on "femininity" subscales, apparently reflecting dependent and nondefensive personality types. In addition, personality measures defined psychotrope users as precise, methodical, cautious, serious, unassertive, and modest. The incompleteness of present unidirectional models of psychotropic drug use are discussed. Suggestions for future research include encompassing the cognitive organization of the psychotrope user within the context of social, affective, and physician influences on this form of coping style.

Effect of patient demand for drugs on physician prescribing.

In a controlled setting with symptoms and demographic variables held constant, differences in physicians' ratings of symptoms, diagnosis and prescribing of drugs were explored in response to six videotaped patients of differing age groups who either demanded drugs or presented somatic complaints. There was a 1.2:1 ratio of prescriptions given to female versus male patients; demand for drugs resulted in significantly lower prescription rates, drugs prescribed, and multiple prescriptions; and those patients who presented somatic complaints received significantly higher amounts of minor tranquilizers. Older patients were prescribed a significantly greater number of drugs than younger patients, particularly in the antidepressant classification, and differences in symptom ratings but not in prescription rates were seen between male and female physicians.

Medical drug use by women: symptoms and change attributions.

Symptom groups of depression, psychic anxiety, somatic anxiety, and cognitive impairment; and attributions of symptom relief to either self or others were assessed with 179 French-speaking women who were using psychotropic drugs at different rates. Drug consumers reported significantly more often than abstainers that symptom relief results from efforts of others. Occasional users reported distress levels higher than both regular users and abstainers.

Psychotropic drug usage in Quebec urban women: pharmacological aspects.

Data on patterns of psychotropic drug use from a two-part study of Québec urban women are reported. Part I involved telephone interviews with 1187 women on their use of pain, sleep, and psychotropic medications. In Part II, 179 women participated in a further person-to-person interview. Areas covered included frequency and duration of use, efficacy of the product, dosage, presence of undesirable side effects, source of drug information, and the concomitant use of other medications. Diazepam and flurazepam (Valium and Dalmane) were the most frequently consumed psychotropes, with diazepam second only to aspirin as the most commonly used of all the medications. The majority of psychotropic users obtained the drug initially through a general practitioner for nonspecific health reasons, were satisfied with the efficacy of the drug, took the medication as directed, felt informed of the effects, and found no undesirable side effects. Multiple psychotrope use was not prevalent, and users of mood-modifiers were generally alcohol abstainers. The differences between the high and moderate users, including satisfaction with the psychotropes as well as initial dosages, are discussed along with comparative data from other similar drug studies. Findings lend credence to the hypothesis that the vague and ill-defined health problems precipitating a psychotropic prescription may in fact be economic, social, or psychological in origin.

Psychotropic drug use by women: characteristics of high consumers.

One thousand one hundred and eighty-seven women were interviewed concerning their use of psychotropic medication, health and visits to physicians, use of tobacco and alcohol, and life-style and general satisfaction. Subjects were categorized as high, moderate, and non-consumers of psychotropes; respectively, 5.5%, 22.6%, and 71.9% of the sample. High drug consumers typically were older, reported being in poorer health, visited physicians more frequently (and more frequently for undefined reasons), rated themselves as more unhappy, were less well educated, were more likely unemployed, smoked more but drank less alcohol, and were more likely unemployed, smoked more but drank less alcohol, and were more likely to have children than the moderate users or abstainers. The findings are shown to support in part the hypotheses that social and psychological problems of women are expressed vaguely and subsequently are more likely medicalized than those of men. The implications of these findings for drug prevention programs and future research are discussed.

Correlates of psychotropic drug use in women: interpersonal problem solving and depression.

Interpersonal problem solving ability was assessed in a community-based study with 179 French-speaking women who were consuming psychotropic drugs at varying frequencies. Significant differences were found between psychotrope consumers and nonconsumers in problem solving scores, with deficiencies in defining the problem characteristic of regular consumers. When subjects were separated on the basis of the Beck Depression Inventory scores, depressed women were differentiated only in their ability to generate alternatives and provide viable solutions to problems. The results are discussed in terms of difficulties with problem definition which might prompt a physician to prescribe, and the role of problem solving deficiencies in drug use maintenance.