The effect of substitution on anticonvulsant activity of some 5,5-diphenylhydantoin derivatives.

Some 5,5-diarylhydantoins and their 3-amino derivatives were synthesized as phenytoin analogs with enhanced rotational restriction of the benzene moieties. In preliminary pharmacological tests, the compounds symmetrically substituted in the benzene rings proved practically inactive as anticonvulsants. High and prolonged activity was observed with 3-amino-5,5-diphenylhydantoin.

Synthesis and properties of cyclic derivatives of succinic acid with anticonvulsant activity. Part 4.

A series of new phenylsuccinimide derivatives substituted in the aromatic ring and/or at the nitrogen atom was synthesized and tested for activity against pentetrazole- and electroshock-induced convulsions.