[Fetoplacental hormone complex measurements to predict fetal and neonatal viability in insulin-dependent diabetes mellitus]. / Opredelenie urovnei gormonov fetoplatsentarnogo kompleksa s tsel'iu prognoza zhiznesposobnosti ploda i novorozhdennogo pri insulinzavisimom sakharnom diabete.

A dynamic follow-up of 79 pregnant patients with insulin-dependent diabetes mellitus was carried out. Specific fetoplacental hormonal profiles were detected and analyzed in complex with glycemic levels, this permitting the authors obtain new prognostic criteria of fetal and newborn viability. The results helped optimize the policy of following up such patients and the developed prediction regulations allowed preventive measures aimed at improvement of the future baby health status to be carried out before clinical manifestation of fetal intrauterine suffering.

[Pregnancy and labor in women in the region of the accident at the Chernobyl Atomic Electric Power Station]. / Beremennost' i rody u zhenshchin v regione avarii na Chernobyl'skoi AES.

The authors analyze the tentative results of a multiprofile study, including a review of labor histories, examinations of pregnant women and parturients, measurements of fetoplacental hormones, study of the immunity status and microbiocenosis of the mothers and newborns, living in the first (up to 15 Ci/km2) and second (15 to 40 Ci/km2) zones of radioactive contamination. The detected shifts of a compensatory nature were found mostly in women living in the first zone. The disorders found in the women living in the second zone evidenced a decrease of the defense potential of the body, this necessitating nonspecific and correcting therapy during pregnancy, in labor and the postpartum period.

[Preoperative preparation for abdominal delivery of pregnant women with fetal distress]. / Podgotovka k abdominal'nomu rodorazresheniiu beremennykh so stradaniem ploda.

A complex of the methods currently available for examining the fetoplacental system was used in 36 patients with severe extragenital and obstetric abnormalities, which allowed the authors to diagnose fetal affections such as hypoxia, hormonal dysfunction of the fetoplacental system before abdominal delivery. The employment of differential drug preparation for cesarean section with due regard to the severity of the fetus' status, maturity and the pattern of an obstetric and extragenital abnormality enhanced the adaptabilities of the fetus and improved perinatal parameters in cesarean section.

[Hormonal diagnosis of endocrinopathies in the early neonatal period]. / Gormonal'naia diagnostika éndokrinopatii v rannem neonatal'nom periode.

Based on the summarization of the results of hormonal examination of the newborn during the early neonatal period it has been revealed that early diagnosis of endocrinopathies can only be made with the use of the laboratory measurements of the concentrations of the appropriate hormones. For early diagnosis of congenital endocrine diseases the screening made according to the specific hormonal test is the most effective approach. It is necessary to differentiate between alterations associated with congenital endocrine diseases and transitory hormonal reactions due to the derangement of the child's status in the ante-, intra- or postnatal periods.

[Means of lowering the perinatal mortality in pregnant women with diabetes mellitus]. / Puti snizheniia perinatal'noi smertnosti pri sakharnom diabete u beremennykh.

The paper gives some current approaches to the management of pregnant women with diabetes mellitus, in terms of perinatal medicine. These are based on a comprehensive detailed clinical examination of 104 patients, which involves the hormonal fetoplacental complex function, hypophyseo-thyroidal system, hemocoagulation system by using ultrasonic tools (fetal biometry and echocardiography, Doppler echometric studies of the fetoplacental blood flow in the umbilical vein, umbilical artery, and fetal aorta). A differential approach was proposed to the management of pregnancy and delivery of patients with diabetes mellitus, which allows perinatal mortality to be reduced.

[Hormonal diagnosis of fetal adaptation disorders in pregnant women with extragenital and obstetric pathology and the principles of their correction]. / Gormonal'naia diagnostika narushenii adaptatsii ploda u beremennykh s ékstragenital'noi i akusherskoi patologiei i printripy ikh korrektsii.

The evaluation of hormonal adaptation of the fetoplacental unit (FPU) in pregnant women with somatic and obstetric complications has demonstrated 4 patterns of adaptation: normal, stressful, maladaptive and unstable. The distribution of FPU adaptive responses across diagnostic groups correlated with types of diseases and their duration in pregnant women. Controlled heart diseases, chronic pyelonephritis without exacerbations, mild toxemia were mostly associated with a normal FPU adaptation. Decompensated heart disease, acute episodes of chronic pyelonephritis, deteriorating toxemia, decompensated diabetes mellitus produced functional activation of FPU hormones. Pregnant women with stable hypertension in the presence of moderately severe toxemia and essential hypertension showed hormonal FPU maladaptation. Differential evaluation of FPU adaptation in pregnant women with somatic and obstetric diseases provides a guide to a range and sequence of interventions for fetal disorders.

[Secondary amenorrhea caused by hypothyroidism]. / Vtorichnaia amenorea, obuslovlennaia gipotireozom.

The status of the reproductive and pituitary-thyroid systems has been elucidated in patients with amenorrhea secondary to hypothyroidism. Hypothyroidism as a major pathogenetic determinant accounted for 4.3% of secondary amenorrhea. Subclinical thyroid dysfunctions which were detectable only with hormonal assays were found to be prevalent. Clinical and hormonal criteria for diagnosis of this pathogenetic type of secondary amenorrhea were obtained, and efficacy of combined therapy for hypothyroidism, menstrual and reproductive dysfunction was evaluated.

[Characteristics of the immunological status of female animal breeders]. / Osobennosti immunologicheskogo statusa zhenshchin-zhivotnovodov.

Sanitary, hygienic, clinicostatistical and immunologic study of 680 female workers engaged in animal husbandry was carried out. For the assessment of their immunologic status the study was designed to analyze the content of circulating immune complexes, hemolytic activity of the complement system and its components, basic immunoglobulin classes (A, M, G, E) and R-proteins. It was demonstrated that female cattle breeders had higher rate of communicable diseases developing into chronic forms and periodically characterized by acute conditions. The female workers engaged in animal husbandry for a long period of time had a disbalance of the above indicators and significant body allergization.

[Immunologic status of women cattle breeders during pregnancy]. / Immunologicheskii status zhenshchin-zhivotnovodov pri beremennosti.

The study was designed to analyze the content of CIC of the main classes of immunoglobulins (A, M, G, E), R-proteins and hemolytic activity of the complement system and its components (C3, C4, C1) in 1980 pregnant women engaged in agricultural activity. Imbalance of the body protective indicators was detected in the pregnant women engaged in animal husbandry. An infectious process aggravated the above changes. Decrease of body protective characteristics elevated the risk of acute conditions of the chronic infectious process and the emergence of postnatal infectious and inflammatory diseases.