RESUMO
IgG serum levels were measured in 25 patients with cystic fibrosis aged 1 to 19 years and in 4 additional patients deceased over the last 4 years. Levels were correlated with a number of parameters. Twelve patients (group A) had raised IgG levels, and 17 (group B) normal or low levels. Age between groups did not differ. Patients in group A had lower Shwachman score (p less than 0.001), worse Chrispin and Norman radiologic score (p less than 0.05), lower weight (p less than 0.001) and height (p less than 0.05) and lower FVC (p less than 0.05), and FEV1 (p less than 0.01). Raised levels were associated with increased number of serum precipitins against Pseudomonas aeruginosa but not against Staphylococcus aureus. Raised IgG levels might be secondary to heavier bronchial infection, but there is growing evidence that immunologic response in cystic fibrosis may worsen the course of the disease.
Assuntos
Fibrose Cística/sangue , Imunoglobulina G/análise , Adolescente , Peso Corporal , Criança , Pré-Escolar , Fibrose Cística/complicações , Fibrose Cística/imunologia , Fibrose Cística/fisiopatologia , Volume Expiratório Forçado , Humanos , Lactente , Prognóstico , Estudos Prospectivos , Infecções por Pseudomonas/etiologia , Infecções Estafilocócicas/etiologia , Capacidade VitalRESUMO
A case of a one month-old girl with primary osteomyelitis of sternum is described. The presence of a positive blood culture to staphylococcus and the antecedent of respiratory physiotherapy are considered to be important etiologic factors. The proccess had a favorable evolution treated with antibiotics and drainage of subperiostal abscess.
