RESUMO
This study was carried out with the aim of comparing colonic anastomosis cicatrization in rats fed either standard rat chow or a low-residue enteral diet. Energy intake, the evolution of body weight, fecal weight, macroscopic and microscopic evaluation of the anastomoses, anastomotic bursting pressure, and collagen concentration in the anastomotic tissue were all evaluated. Anastomotic complications were more common among the animals fed standard rat chow, and cicatrization was more inflammatory than in the rats given a low-residue enteral diet. Although the latter was more effective in preventing anastomotic complications, it resulted in a lower gain in collagen and hence a diminished resistance to the increase in intraluminal pressure associated with the administration of such diets. Colonic contents, including the fecal bolus and bacteria, may be held responsible for the increased number of complications, the augmentation of collagen content, and the improvement in the resistance to intraluminal pressure.
Assuntos
Colo/cirurgia , Dieta , Nutrição Enteral , Cicatrização , Anastomose Cirúrgica , Animais , Colo/patologia , Colo/fisiopatologia , Masculino , Complicações Pós-Operatórias , Pressão , Ratos , Ratos WistarRESUMO
Presentation of an experimental study comparing the scarring of colic anastomoses performed in Wistar rats fed with three different types of diet: a standard laboratory diet, an enteral low-residue diet and a low-residue diet supplemented with fermentable fibre in short chain fatty acids (pectin). Scarring in the group fed with the standard laboratory diet showed greater anastomotic complications, and the microscopic appearance was more inflamed. The administration of low-residue diets reduced the level of complications, but also reduced the concentration of collagen and the parietal rupture tension. The addition of pectin to a low-residue diet maintained the complications at a low level, and also significantly increased the pressure parameters and the collagen concentration.
