The effects of the tabletting machine speed on physical characteristics of pharmaceutical powders.

During compaction, crystallised materials are subjected to fragmentation which depends not only on the deformation undergone but also on the punch speed of the tabletting machine. Then, this process is followed by reagglomeration of the ground particles which also depends on the punch speed. Likewise, it was shown that materials with a relatively low specific heat such as Emcompress and acetylsalicylic acid are more sensitive to machine speed than boric acid or sodium chloride. From the present study it appears that tablet hardness is not a sufficient criterion to guarantee the reproducibility of a production batch.

[A study by infrared spectroscopy of interactions between the time of disintegration of tablets and liberation of the active principal]. / Mise en évidence par spectroscopie infrarouge des interactions affectant le temps de délitement de comprimés et la vitesse de libération du principe actif.

It was shown that the study of the infrared spectra of a drug and of the mixture drug + additives facilitates the preliminary studies for a tablet formulation. Thus, any interaction that may occur or affect the product stability can be detected and located. Furthermore, it was noticed that an interaction between an active ingredient and the various additives may modify the tablet desintegration time, but not necessarily the dissolution rate of this substance.