Assuntos
Diclofenaco/uso terapêutico , Síndrome Nefrótica/tratamento farmacológico , Adulto , Pressão Sanguínea/efeitos dos fármacos , Creatinina/sangue , Diclofenaco/farmacocinética , Diclofenaco/farmacologia , Eletrólitos/sangue , Feminino , Humanos , Masculino , Proteinúria/tratamento farmacológicoAssuntos
Granulomatose com Poliangiite/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Feminino , Seguimentos , Granulomatose com Poliangiite/classificação , Granulomatose com Poliangiite/patologia , Humanos , Rim/patologia , Testes de Função Renal , Masculino , Pessoa de Meia-Idade , Especificidade de Órgãos/fisiologiaAssuntos
Ciclofosfamida/administração & dosagem , Granulomatose com Poliangiite/terapia , Nefropatias/terapia , Pneumopatias/terapia , Plasmaferese , Combinação Trimetoprima e Sulfametoxazol/administração & dosagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Creatinina/sangue , Ciclosporina/administração & dosagem , Feminino , Granulomatose com Poliangiite/mortalidade , Humanos , Nefropatias/mortalidade , Pneumopatias/mortalidade , Masculino , Pessoa de Meia-Idade , Prednisolona/administração & dosagem , Estudos Retrospectivos , Taxa de SobrevidaRESUMO
The renal involvement in sarcoidosis can be demonstrated as nephrocalcinosis, nephrolithiasis, granulomatous nephritis, and glomerulonephritis. The clinical signs of a renal manifestation are inferior than the morphological findings, so that the reported frequency of 9-25% is an approximate value. In the literature the glomerular changes are rare. In the case of glomerulonephritis the membranous form is dominating; an extracapillar-proliferative glomerulonephritis is described in only 3 cases in the literature. The course of a 16-year-old male patient with an extracapillar-proliferative glomerulonephritis and M. Boeck is described in detail. After a prednisolone therapy for 2 years, which was introduced by methylprednisolone at 1000 mg for 3 days, the renal function was improved continuously.
Assuntos
Glomerulonefrite/patologia , Sarcoidose/patologia , Adolescente , Humanos , Rim/patologia , Pulmão/patologia , Pneumopatias/patologia , MasculinoAssuntos
Hematúria/etiologia , Adulto , Diagnóstico Diferencial , Feminino , Hematúria/induzido quimicamente , Humanos , Masculino , Fatores de RiscoRESUMO
For the judgment of the success of the immunosuppressive therapy of chronic glomerulonephritis 400 patients (242 males and 158 females) at an average age of 31.2 years were examined after an average duration of treatment of 31.9 months. Apart from the renal function (serum creatinine), the histological and immunohistological form of the glomerulonephritis for the valuation further clinico-paraclinical data were taken into consideration: proteinuria, nephrotic syndrome, arterial hypertension and the combination of nephrotic syndrome and arterial hypertension. At the beginning of the treatment 293 of 400 patients (73.2%) had a normal renal function, 107 of 400 patients (26.8%) were initially renal-insufficient. 16 of 400 patients (4.0%) had additionally a pyelonephritis and 12 of 400 patients (3.0%) had a lupus nephritis. 27 of 400 patients (6.9%) developed a terminal renal insufficiency after an average duration of observation of 40.5 months. Complications caused by therapy were registered in 104 of 400 patients (26.0%). Recommendations for the present therapy of chronic glomerulonephritis are formulated.
