Diversity and Resistance to Change: Macro Conditions for Marginalization in Post-industrial Societies.

We argue that two society-level properties-resistance to change and diversity within a culture-significantly affect agents' degrees of marginalization, which is here defined as access to cultural knowledge and institutional means for accomplishing cultural goals. We develop an agent-based model using findings from Norasakkunkit et al. (Norasakkunkit and Uchida, 2011, 2014; Norasakkunkit et al., 2012). We found that varying the degrees of resistance to change and diversity affected similarities between the mainstream subculture and other subcultures, changes in subcultures over time, and the relative population proportion of each subculture. In particular, we found that high diversity and low resistance to change created the greatest cultural changes within the marginalized subculture over time and allowed for maximal growth of rebellious subcultures. Also, low diversity and high resistance to change allowed for maximal growth of the marginalized subcultures and the greatest overlap between the marginalized and mainstream subcultures. These have important implications for understanding the emergence and maintenance of marginalization in post-industrial societies.

Anti-tissue remodeling effects of corticosteroids: fluticasone propionate inhibits fibronectin expression in fibroblasts.

OBJECTIVES: Tissue remodeling often accompanies diseases such as COPD that are caused by or aggravated by tobacco exposure. Inhaled or systemic corticosteroids are frequently used for the treatment of these illnesses, and their beneficial effects are often ascribed to their anti-inflammatory properties. However, their role in tissue remodeling remains unclear. This study was designed to evaluate the role of corticosteroids in matrix expression in vitro. DESIGN: We investigated the effects of the corticosteroid fluticasone propionate (FP) on the production of fibronectin by fibroblasts before and after stimulation by nicotine, a plant alkaloid found in tobacco. Fibronectin is an extracellular matrix glycoprotein found elevated in the alveolar lining fluid and airway walls of subjects with obstructive lung disease, and is considered a marker of tissue remodeling after injury. RESULTS: FP, 1 micromol/L, inhibited the expression of fibronectin messenger RNA and protein in unstimulated NIH-3T3 cells and primary lung fibroblasts, as well as in fibroblasts stimulated with nicotine. The inhibitory effect of FP occurred at the level of gene transcription as demonstrated in lung fibroblasts expressing a construct containing the human fibronectin promoter connected to a luciferase reporter gene, but posttranscriptional effects also appeared involved. Electrophoresis mobility gel shift assays revealed that FP inhibited phosphorylation and DNA binding by the cyclic adenosine monophosphate response element binding protein, a transcription factor required for constitutive and nicotine-induced fibronectin expression. CONCLUSIONS: Together, these data suggest that FP could diminish lung tissue remodeling by inhibiting the production of fibronectin in lung fibroblasts.