[Talc-induced pulmonary granulomas in drug addicts].

Among the diseases accompanied by granuloma formation in the lung, there is so-called granulomatosis developing in injection drug users who have been long injecting suspensions of oral medications containing talc and other water insoluble fillers. 102 deaths of chronic intravenous drug users were examined; 12 of whom showed pulmonary talc-induced granulomatosis. Their morphology was studied using polarized light microscopy. The main mechanisms of thanatogenesis in lethal cases within the first hours after intravenous injection of talc-containing oral medication suspensions are explained.

[A clinical and morphological study of status asthmaticus]. / Kliniko-morfologicheskoe issledovanie pri astmaticheskom statuse.

Clinical and morphologic studies were carried out in 230 patients suffering a grave course of an exacerbation of infectious bronchial asthma. A protracted attack of the condition was detected in 70 patients, in 80 patients status asthmaticus, Stages I-II was found, 50 patients suffered a Stage III status asthmaticus, and 30 patients were hospitalized in the terminal state and died within 12 hours since admission. The circulatory, metabolic, immunologic homeostasis parameters were studied, morphologic, examination of pulmonary, tracheal, cardiac, cerebral, splenic and hepatic tissue was carried out in 30 patients who died at the height of the status asthmaticus. The authors have analyzed the contribution of the homeostasis parameters to the formation of the critical state in status asthmaticus and the relationships of these parameters between each other and with the condition severity. The severity of the patients' condition was found closely related to the degree of respiratory, circulatory, and metabolic disturbances. Respiratory failure and circulatory disorders were the principal clinical manifestations of status asthmaticus, though the disorders of the metabolic and immunologic homeostasis also much contributed to the formation of a critical condition due to status asthmaticus. Characteristic histomorphologic changes of the viscera, detected at autopsy, were the morphologic equivalent of these clinical symptoms. The findings regarding status asthmaticus as a critical state that is characterized by the development of multiorgan insufficiency involving the formation of incompetence of natural detoxication routes.

[Clinico-morphologic variants of hemochromatosis]. / Kliniko-morfologicheskie varianty gemokhromatoza.

Clinicomorphological analysis of 8 necropsies of primary hemochromatosis permitted recognizing 2 main versions of the disease course: with a primary damage to the liver and pancreas and with a primary injury to the heart, with the latter version being encountered in patients of a younger age and running a more malignant course. The thanatogenesis of patients with hemochromatosis may be linked with acute renal failure.