[Specific activity of an UV-inactivated antirabies vaccine made from brain tissue administered in a shortened schedule]. / Spetsificheskaia aktivnost' inaktivirovannoi UF-luchami antirabicheskoi vaktsiny iz tkani mozga pri sokrashchennoi skheme vvedeniia.

The results obtained in the study of the specific potency of rabies vaccine prepared from sheep brain tissue and inactivated by UV irradiation indicate that, even in the presence of the lowest immunogenicity index (0.5), 5-6 injections of the vaccine, made not daily, but at interval of 3 and 7 days, induced the production of antibodies in the titers not lower than those resulting from 14-20 daily injections of the same vaccine or Fermi vaccine. The preparation inactivated by UV irradiation should be introduced for therapy according to the shortened immunization schedule with intervals, taking into account the immunogenicity index.

[Effect of specific antibodies on active immunity development in those inoculated with an antirabies vaccine]. / Vliianie spetsificheskikh antitel na vyrabotku aktivnogo immuniteta u privitykh antirabicheskoi vaktsinoi.

The study of the effect of gamma globulin introduced in different doses (0.5 and 0.25 ml/mg) in combination with Fermi rabies vaccine (observations on humans were made) and with cerebral rabies vaccine inactivated by UV irradiation (in animal experiments) demonstrated that the injection of the higher doses of gamma globulin resulted in lower geometrical mean of antibody titers. Therefore, in combined administration of rabies vaccine and gamma globulin for postexposure rabies prevention it is advisable to reduce the dose of gamma globulin by one-half.

[Antigenic properties of concentrated antirabies vaccine in accelerated immunization schedules]. / Antigennye svoistva kontsentrirovannoi antirabicheskoi vaktsiny pri ukorochennykh skhemakh immunizatsii.

The study of purified rabies vaccine (tissue culture origin), concentrated 100 fold, in animal experiments has shown that the preparation, if introduced intramuscularly in 2 or 3 injections, has high antigenic activity. The intramuscular injections of the vaccine at an interval of 21 days or at intervals of 21 and 30 days after the first injection has proved to be the optimum immunization schedule ensuring a sufficiently high accumulation of virus-neutralizing antibodies by days 30--45. To achieve higher antibody titers, the vaccine may be introduced intradermally after 2 indispensable intramuscular injections of the preparation.

[Antigenic activity and the reactogenicity of UV ray-inactivated antirabies vaccine from the brain of sheep]. / Antigennaia aktivnost' i reaktogennost' inaktivirovannoi UF-luchami antirabicheskoi vaktsiny iz mozga ovets.

Tests in volunteers showed that the reactogenicity of rabies vaccine prepared from sheep brain and inactivated with ultraviolet rays was not greater than the reactogenicity of Fermi vaccine. At the same time it was found to have a higher activity when injected both in the form of 5% suspension (in full and decreased doses) and with brain tissue content as low as 2.5%.

[Serological method of detecting antirabies antibodies]. / Serologicheskii metod obnaruzheniia antirabicheskikh antitel.

The possibility of the determination of rabies antibodies by the serological method has been demonstrated, involving the use of culture rabies virus, strain Vnukovo-32, concentrated and purified by high speed centrifugation, for the sensitization of anserine erythrocytes. The neutralization test in mice and the passive hemagglutination test showed a correlation in rabies antibody titers in the sera of animlas immunized with rabies vaccines. The advantages of the passive hemagglutination test consist in the rapidity of obtaining the results, in a simple and economic method of carrying out the test.

[Antigenic activity of a gamma-ray inactivated, concentrated, purified cultured antirabies vaccine]. / Antigennaia aktivnost' inaktivirovannoi gamma-luchami kontsentrirovannoi ochishchennoi kul'tural'noi antirabicheskoi vaktsiny.

Concentrated purified cultural rabies vaccine inactivated with gamma-rays caused in intramuscular injection (2 ml twice at an interval of 23 and 21 days) production of virus-neutralizing antibodies both in experiments on animals and in the vaccinated volunteers in titres not below those obtained in persons given a complete course of cultural rabies vaccine inoculations. No untoward reactions occurred.