1.
Bioorg Med Chem Lett
; 9(9): 1273-8, 1999 May 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10340613
RESUMO
The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.