RESUMO
At the same time they are reporting the current obesity epidemic, U.S. physicians are also seeing a dramatic increase in the prevalence of type 2 diabetes in adolescent patients. In this article, Drs Laurencin, Goldschmidt, and Fisher summarize the prevalence and risk factors, clinical presentation, diagnosis, and treatment of type 2 diabetes in adolescents. They also offer interventional strategies for both lifestyle change and pharmacologic management.
Assuntos
Diabetes Mellitus Tipo 2 , Adolescente , Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/psicologia , Diabetes Mellitus Tipo 2/terapia , Humanos , Hipoglicemiantes/uso terapêutico , Estilo de Vida , Programas de Rastreamento , Guias de Prática Clínica como Assunto , Psicologia do Adolescente , Fatores de Risco , Estados Unidos/epidemiologiaRESUMO
Slices of livers from neonatal, 7-day-old and adult rats were fixed in osmium tetroxide or a formaldehyde-osmium tetroxide sequence and processed for electron microscopy. Mitochondria from neonatal hepatic parenchymal cells are pleomorphic. Disc-shaped forms are common. In 7-day-old animals, cylinders are the most numerous single form, discs are present but smaller, and spherical forms increase in number. In the adult, mitochondria are predominantly cylindrical in form. The average volume of neonatal mitochondria is greater than that of 7-day-old or adult mitochondria.
