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1.
Chiropr Man Therap ; 29(1): 12, 2021 03 24.
Artigo em Inglês | MEDLINE | ID: mdl-33761956

RESUMO

BACKGROUND: Managing low back pain (LBP) often involves MRI despite the fact that international guidelines do not recommend routine imaging. To allow us to explore the topic and use this knowledge in further research, a reliable method to review the MRI referrals is needed. Consequently, this study aimed to assess the inter-rater reliability of a method evaluating lumbar spine MRI referrals' appropriateness. METHODS: Four inexperienced students (chiropractic master's students) and a senior clinician (chiropractor) were included as independent raters in this inter-rater reliability study. Lumbar spine MRI referrals from primary care on patients (> 18 years) with LBP with or without leg pain were included. The referrals were classified using a modified version of the American College of Radiology (ACR) imaging appropriateness criteria for LBP. Categories of appropriate referrals included; fractures, cancer, previous surgery, candidate for surgery or suspicion of cauda equina. Inappropriate referrals included lacking information on previous non-surgical treatment, no word on non-surgical treatment duration, or "other reasons" for inappropriate referrals. After two rounds of training and consensus sessions, 50 lumbar spine MRI referrals were reviewed independently by the five raters. Inter-rater reliability was quantified using unweighted Kappa statistics, and the observed agreement was calculated with both a pairwise comparison and an overall five-rater comparison. RESULTS: Inter-rater reliability was substantial, with a Kappa value for appropriate vs. inappropriate referrals of 0.76 (95% CI: 0.55-0.89). When six and eight subcategories were evaluated, the Kappa values were 0.77 (95% CI: 0.58-0.91) and 0.82 (95% CI: 0.72-0.92), respectively. The overall percentage of agreement for appropriate and inappropriate referrals was 92% and ranged from 88 to 98% for the pairwise comparisons of the five raters' results. For the six and eight subcategories, the overall agreement was 92 and 88%, respectively, ranging from 88 to 98% and 84-92%, respectively, for the pairwise comparisons. CONCLUSION: The inter-rater reliability of the evaluation of the appropriateness of lumbar spine MRI referrals, according to the modified ACR-appropriateness criteria, was found to range from substantial to almost perfect and can be used for research and quality assurance purposes.


Assuntos
Fidelidade a Diretrizes/classificação , Dor Lombar/diagnóstico por imagem , Imageamento por Ressonância Magnética , Encaminhamento e Consulta/classificação , Adulto , Dinamarca , Humanos , Reprodutibilidade dos Testes
2.
PLoS One ; 15(8): e0234409, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32857766

RESUMO

BACKGROUND: An abdominal aortic aneurysm (AAA) is a progressive chronic dilatation of the abdominal aorta with terminally rupture when the aortic wall is so weakened that aortic wall stress exceeds wall strength. No effective medical treatment exists so far. We aimed to test whether intraluminal admission of Penta-Galloyl Glucose (PGG) treatment in a rodent AAA model could hold the potential to inhibit aneurysmal progression. METHOD: Male Sprague Dawley rats had either intraluminal elastase infused for AAA induction or saline to serve as controls. In two independent experimental series, elastase was used to induce AAA followed by an intraluminal PGG (directly or by a drug eluting balloon) treatment. All rats were followed for 28 days and euthanized. In both series, maximal infrarenal aortic diameter was measured at baseline and at termination as a measure of AAA size. In series 2, maximal internally AAA diameter was followed by ultrasound weekly. AAA tissues were analyzed for elastin integrity by millers stain, collagen deposition by masson trichrome staining. In other AAA tissue samples the mRNA level of CD45, lysyloxidase (LOX), lysyloxidase like protein 1 (LOXL1) were determined by qPCR. RESULTS: Direct administration of PGG significantly reduced AAA expansion when compared to controls. PGG treatment resulted in a higher number and more preserved elastic fibers in the aneurysmal wall, while no significant difference was seen in the levels of CD45 and LOX mRNA levels. The drug eluting balloon (DEB) experiment showed no significant difference in AAA size observed neither macroscopically nor ultrasonically. Also the aneurysmal mRNA levels of CD45, LOX and LOXL1 were unchanged between groups. CONCLUSION: A significant reduced expansion of AAAs was observed in the PGG group, suggesting PGG as a drug to inhibit aneurysmal progression, while administration through a DEB did not show a promising new way of administration.


Assuntos
Aneurisma da Aorta Abdominal/tratamento farmacológico , Taninos Hidrolisáveis/administração & dosagem , Animais , Aorta Abdominal/diagnóstico por imagem , Aorta Abdominal/efeitos dos fármacos , Aorta Abdominal/patologia , Aneurisma da Aorta Abdominal/metabolismo , Aneurisma da Aorta Abdominal/patologia , Modelos Animais de Doenças , Progressão da Doença , Tecido Elástico/efeitos dos fármacos , Tecido Elástico/patologia , Infusões Intralesionais/instrumentação , Infusões Intralesionais/métodos , Masculino , Elastase Pancreática/administração & dosagem , Proteína-Lisina 6-Oxidase/genética , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Ratos , Ratos Sprague-Dawley
3.
Acta Orthop ; 91(3): 326-330, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32056475

RESUMO

Background and purpose - Percutaneous needle fasciotomy (PNF) is a minimally invasive treatment option for Dupuytren contracture, which has gained momentum worldwide in recent years. However, evidence regarding safety and severe complications associated with PNF is sparse. Thus, we evaluated safety of a specific PNF method in the largest cohort reported in literature.Patients and methods - This is a single-center, register-based, observational study on PNF treatments between 2007 and 2015. The study cohort was identified by the Danish National Patient Registry, and diagnosis codes and procedure codes were used to identify potential severe postoperative complications such as: tendon rupture, nerve damage, infection, amputation, and reflex dystrophy for all index treatments. The Danish National Prescription Registry was used to identify non-hospital-treated infections. All index treatments and postoperative complications were verified by review of medical records.Results - 2,257 patients received PNF treatment of 3,331 treated finger rays. Median follow-up was 7.2 years (interquartile range: 4.9-9.5 years, range 1-12 years). 4 patients sustained flexor tendon rupture. 1 patient had digital nerve damage. 2 patients had an infection treated in hospital, while 31 patients received antibiotics in the primary sector for an infection or based on suspicion of an infection after PNF. None of the infections required surgical intervention. No finger amputations or ipsilateral upper limb reflex dystrophy cases were registered in relation to the procedure.Interpretation - Percutaneous needle fasciotomy for Dupuytren contracture is a safe procedure with a low rate of severe postoperative complications when a specific PNF method is applied.


Assuntos
Contratura de Dupuytren/cirurgia , Fasciotomia/métodos , Dedos/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Fasciotomia/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos , Agulhas , Sistema de Registros , Resultado do Tratamento , Adulto Jovem
4.
Acta Orthop ; 90(5): 439-444, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31274038

RESUMO

Background and purpose - Length of hospital stay (LOS) following total hip arthroplasty (THA) has been markedly reduced. Recently, same-day THA (SD-THA) was introduced, and previous studies have indicated satisfactory safety. However, studies are heterogeneous and only a few report results on SD-THA when using a posterolateral surgical approach. Thus, our aim was to evaluate the feasibility of and complications after SD-THA when using a posterolateral approach. Patients and methods - Consecutive patients scheduled for SD-THA between October 2015 and June 2016 were included. Eligibility criteria for SD-THA were: primary THA, motivation for same-day procedure, age > 18 years, ASA I or II, and the presence of a support person who could remain with the patient for 24 hours after surgery. A posterolateral surgical approach was used. Data were collected retrospectively from hospital records and the Danish National Patient Registry. Outcome measures were: complications during admission, LOS, causes of prolonged admission, and prevalence and causes of readmission at 90 days' follow-up. Results - 102 of 116 (88%) patients scheduled for SD-THA were discharged on the day of surgery. The remaining 14 patients were discharged the following day. Primary causes of prolonged admission were: dizziness/nausea, pain, and wound seepage. 7 patients had an estimated blood loss above 400 mL, but all were discharged as planned. No major complications occurred during admission. At follow-up, 3 patients had been readmitted due to pneumonia, wound infection, and dislocation, respectively. Interpretation - The results indicate that SD-THA performed with a posterolateral approach is feasible and can be performed with a low complication rate in a selected group of patients.


Assuntos
Procedimentos Cirúrgicos Ambulatórios/efeitos adversos , Artroplastia de Quadril/efeitos adversos , Complicações Pós-Operatórias/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Procedimentos Cirúrgicos Ambulatórios/métodos , Artroplastia de Quadril/métodos , Estudos de Coortes , Procedimentos Clínicos/organização & administração , Estudos de Viabilidade , Feminino , Humanos , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Alta do Paciente , Readmissão do Paciente/estatística & dados numéricos , Estudos Retrospectivos
5.
J Med Internet Res ; 21(7): e9805, 2019 07 04.
Artigo em Inglês | MEDLINE | ID: mdl-31274113

RESUMO

BACKGROUND: Internet use within health care contexts offers the possibility to provide both health information and peer support. Internet Support Groups (ISGs) for patients may offer advantages, which are not found in face-to-face support. In patients undergoing lumbar spine fusion (LSF), ISGs could have a particular potential, as peer support on the web might bridge the decreased satisfaction with social life and social isolation found within these patients. ISGs might in this way contribute to increasing the functioning and overall health-related quality of life. However, LSF patients may generally belong to a group of citizens not prone to internet and online peer support. However, our knowledge of how LSF patients use ISGs is limited. OBJECTIVE: The aim of this study was to describe the characteristics of users of an ISG and thematically explore the content of ISG interactions in Danish patients undergoing instrumented LSF because of degenerative spine disorders. METHODS: Participants were recruited from a randomized controlled trial and included in a prospective cohort with a mixed methods design. Sociodemographic characteristics and information on psychological well-being (symptoms of anxiety and depression) were obtained at baseline and 1 to 5 weeks before surgery. Usage of the ISG was registered from baseline until 3 months after surgery. All posts and comments were collected, and content analysis was performed. RESULTS: A total of 48 participants comprised the study population, with a mean age of 53 years (range 29-77). Of the participants, 54% (26/48) were female, 85% (41/48) were cohabitating, 69% (33/48) were unemployed, and the majority (69% [33/48]) had secondary education. Approximately one-third of the participants had symptoms of depression (35%, 17/48) and anxiety (29%, 14/48). Overall, 90% (43/48) of the participants accessed the ISG. No correlations were found between sociodemographic characteristics and access to the ISG. Women were more prone to be active users, contributing with posts (P=.04). Finally, active users contributing with posts or comments had viewed more pages, whereas passive users, users without posts or comments, had more interactions with the ISG (P<.001). The ISG contained 180 conversation threads, generating 354 comments. The 180 conversation threads in the ISG were constituted by 671 independent dialogue sequences. On the basis of those 671 dialogue sequences, 7 thematic categories emerged. CONCLUSIONS: Sociodemographic characteristics were not predictors of ISG use in this study, and active use was found to be gender dependent. Content of interactions on the ISG emerged within 7 thematic categories and focused on social recognition, experience of pain or use of pain medication, experience of physical activity or physical rehabilitation, expression of psychosocial well-being, advising on and exploring the ISG, and employment, which seemed to correspond well with the prevalent occurrence of symptoms of anxiety and depression.


Assuntos
Internet/normas , Grupos de Autoajuda/normas , Apoio Social , Fusão Vertebral/reabilitação , Telemedicina/métodos , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
6.
Spine J ; 19(5): 827-839, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30500464

RESUMO

BACKGROUND: Approximately one-third of patients undergoing spine surgery have symptoms of anxiety and depression that correlate with pain, disability, and lower health-related quality of life. The use of web-based informative strategies before surgery and principles from cognitive behavioral therapy, have been applied in other patient groups, facilitating mobility and encouraging beneficial coping behavior. PURPOSE: To examine the effect of a web-based Spine Platform featuring Interaction and Information by Animation (w-SPIINA) on symptoms of anxiety and depression, pain, disability, and health-related quality of life. STUDY DESIGN: A single-center, two-arm, randomized controlled trial PATIENT SAMPLE: One hundred fourteen consecutive patients scheduled for instrumented lumbar spine fusion due to degenerative disc disease or spondylolisthesis. OUTCOME MEASURES: Primary outcome was the change in self-reported Hospital Anxiety and Depression Scale (HADS) scores from baseline to 3-month follow-up. Secondary outcomes were change in HADS 1-day before surgery 2days and 6 months after and changes in self-reported disability measured on the Oswestry disability index (ODI), quality of life (EQ-5D-5L questionnaire), and the low back pain rating scale (LBPRS) 2days and 3 and 6 months after surgery. METHOD: Patients were randomized to either a control group receiving a standard information regimen or an intervention group gaining access to w-SPIINA in addition to the standard regimen. The independent charity Helsefonden contributed $45,000, the Health Research Fund of the Regional Hospital Central Jutland contributed $10,000, and the Toyota foundation contributed $10,000 to remunerate a dedicated investigator. The authors have no conflict of interest to declare. RESULTS: There was no statistically significant difference within the w-SPIINA group and the control group regarding changes in HADS at 3-month follow-up (p≥.37). Approximately 40% reached minimum clinically important difference (MCID) in the w-SPIINA group on the HADS at 3 months. In the control group 50% reached MCID on anxiety subscale and 35% on the depression subscale at 3 months. No statistically significant differences were found between groups with regard to the overall outcomes at any of the predefined time points. CONCLUSION: Providing patients with access to w-SPIINA in addition to a standard information regimen had no additional effect on HADS and patient-reported outcomes1day before, 2days, 3 or 6 months after surgery. However, a high compliance and degree of interaction with w-SPIINA indicates that this mode of web-based support could be applicable in this group of patients.


Assuntos
Ansiedade/prevenção & controle , Depressão/prevenção & controle , Relações Interpessoais , Educação de Pacientes como Assunto/métodos , Complicações Pós-Operatórias/epidemiologia , Fusão Vertebral/efeitos adversos , Adulto , Idoso , Ansiedade/etiologia , Depressão/etiologia , Feminino , Humanos , Internet , Degeneração do Disco Intervertebral/complicações , Degeneração do Disco Intervertebral/psicologia , Degeneração do Disco Intervertebral/cirurgia , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/psicologia , Fusão Vertebral/psicologia , Espondilolistese/complicações , Espondilolistese/psicologia , Espondilolistese/cirurgia
7.
Orthop Nurs ; 37(6): 363-371, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30451773

RESUMO

BACKGROUND: It is seldom questioned, if information delivered (to a patient) actually produces knowledge. There is a lack of understanding of how patients in general, surgical patients in particular, perceive, process, and translate clinical information in their everyday lives. The objective of this study was to elucidate how patients undergoing spinal fusion surgery manage and assimilate information provided by clinicians and how they adapt and embrace this information pre- and postsurgery. METHODS: The study employed qualitative methods of ethnographic observation and semistructured interview with a total of 14 individuals, that is, spinal fusion patients (n = 6) and clinicians (n = 8) over a 4-month period in 2014. RESULTS: The results highlight that in the course of treatment, patients embrace or reject information on the basis of their previous experience, expectations, and confidence in their own ability. Overall, patients adjusting to everyday life after spinal fusion surgery used 4 strategies of information processing about their individual life situation. Patients do not use just one of these strategies but may use a number of strategies depending on the situation. Such production of knowledge is pivotal to the behavior of patients through their treatment trajectory. CONCLUSIONS: This study points to the challenges of supporting patients to assimilate information and affect health-related behaviors, recognizing that knowledge and behavior change are emergent processes in patients and not a linear outcome of information.


Assuntos
Comportamentos Relacionados com a Saúde , Letramento em Saúde , Educação de Pacientes como Assunto/métodos , Fusão Vertebral/reabilitação , Adulto , Idoso , Antropologia Cultural , Atenção à Saúde , Feminino , Humanos , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade , Enfermagem Ortopédica , Pesquisa Qualitativa , Fusão Vertebral/métodos
8.
Spine J ; 18(7): 1272-1285, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29649613

RESUMO

BACKGROUND: Symptoms of preoperative anxiety and depression occur in approximately one-third of patients with chronic back pain undergoing surgery. In the last 2 decades, several studies have established that preoperative anxiety and depression are important outcome predictors of greater pain and physical impairments, and lower health-related quality of life in patients undergoing spine surgery. To accommodate symptoms of anxiety and depression and thereby better surgical outcomes, we need to identify factors associated with these symptoms. PURPOSE: We aimed to identify factors associated with symptoms of anxiety and depression in adults both before and after undergoing spinal surgery. STUDY DESIGN: An integrative literature review was carried out. METHODS: The independent charity Helsefonden supported this literature review by contributing $45,000 to remunerate a dedicated investigator. A systematic literature search was conducted in PubMed, CINAHL, PsycINFO, Embase, Scopus, Cochrane, and Web of Science. A three-step selection and assessment process was conducted; titles and abstracts of 1,124 articles were skimmed for relevance and of these, 53 articles were found to be of relevance and were read in full. Articles not meeting the inclusion criteria (n=26) were excluded. The 31 articles were critically appraised for methodological validity; 14 of these were synthesized and analyzed using a convergent qualitative design to transform both qualitative and quantitative articles into qualitative findings. RESULTS: Fourteen studies were included, reporting results based on 4,833 participants, 3,017 men and 1,816 women, whose mean age was approximately 49 years. From these results, we extracted 75 individual findings, which we then divided into five categories of factors associated with anxiety and depression both before and after undergoing spine surgery: pain, information, disability, employment, and mental health. CONCLUSIONS: Five categories of interacting factors that influenced symptoms of anxiety and depression both before and after surgery were identified: pain, lack of information, disability, return to work, and mental health. Information appears to have a regulating effect on anxiety and depression.


Assuntos
Ansiedade/epidemiologia , Depressão/epidemiologia , Procedimentos Neurocirúrgicos/psicologia , Coluna Vertebral/cirurgia , Adulto , Ansiedade/etiologia , Dor nas Costas/psicologia , Dor nas Costas/cirurgia , Depressão/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Fatores de Risco
9.
Acta Orthop ; 88(1): 41-47, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28097941

RESUMO

Background and purpose - Telemedicine could allow patients to be discharged more quickly after surgery and contribute to improve fast-track procedures without compromising quality, patient safety, functionality, anxiety, or other patient-perceived parameters. We investigated whether using telemedicine support (TMS) would permit hospital discharge after 1 day without loss of self-assessed quality of life, loss of functionality, increased anxiety, increased rates of re-admission, or increased rates of complications after hip replacement. Patients and methods - We performed a randomized controlled trial involving 72 Danish patients in 1 region who were referred for elective fast-track total hip replacement between August 2009 and March 2011 (654 were screened for eligibility). Half of the patients received a telemedicine solution connected to their TV. The patients were followed until 1 year after surgery. Results - Length of stay was reduced from 2.1 days (95% CI: 2.0-2.3) to 1.1 day (CI: 0.9-1.4; p < 0.001) with the TMS intervention. Health-related quality of life increased in both groups, but there were no statistically significant differences between groups. There were also no statistically significant differences between groups regarding timed up-and-go test and Oxford hip score at 3-month follow-up. At 12-month follow-up, the rates of complications and re-admissions were similar between the groups, but the number of postoperative hospital contacts was lower in the TMS group. Interpretation - Length of postoperative stay was shortened in patients with the TMS solution, without compromising patient-perceived or clinical parameters in patients undergoing elective fast-track surgery. These results indicate that telemedicine can be of value in fast-track treatment of patients undergoing total hip replacement.


Assuntos
Artroplastia de Quadril/métodos , Deambulação Precoce/métodos , Tempo de Internação/tendências , Qualidade de Vida , Telemedicina , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo
10.
Hip Int ; 27(1): 60-65, 2017 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-27791240

RESUMO

INTRODUCTION: Recent reports indicate that total hip arthroplasty (THA) can be further accelerated and might be managed as day-case. This could provide benefits to health care expenditure, lower patient risks and change patient satisfaction. We evaluated the feasibility, efficacy, safety and patient satisfaction of same-day (<12 hours) THA operation and discharge. METHODS: Consecutive patients were screened for eligibility (primary THA, ASA 1 or 2 physical status) and the presence of a support person to follow the patient for 48 hours postoperatively in an observational study. THA was managed as day-case (<12 hours) through patient selection, preoperative patient education programme, light spinal anaesthesia, low opioid usage, and early mobilisation. Efficacy and logistics were analysed and compared to current accelerated practice. Patient satisfaction was compared to existing fast-track THA and elective surgery cohorts. RESULTS: 29 consecutive patients were screened and 20 participated (69%). 17/20 patients (85%) were released on the day of surgery. There were no serious adverse events or complications, and no infections or readmission at 6-week follow-up. Patient overall satisfaction rating (1-5) was high (4.75), higher than in a 301-patient cohort (4.53) (THA and total knee arthroplasty) from the same centre (p = 0.23), and higher than in a national, elective surgery cohort (4.3) (p = 0.04). CONCLUSIONS: We report the feasibility of day-case THA. Safety, complications and overall patient acceptance were satisfactory. Light spinal anaesthesia facilitated quick transit through postanaesthesia care unit to early mobilisation. Support persons and patient education may play a part in high patient acceptance of day-case surgery.


Assuntos
Procedimentos Cirúrgicos Ambulatórios/métodos , Artroplastia de Quadril/métodos , Tempo de Internação , Alta do Paciente , Segurança do Paciente , Idoso , Artroplastia de Quadril/efeitos adversos , Dinamarca , Procedimentos Cirúrgicos Eletivos/métodos , Estudos de Viabilidade , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica , Satisfação do Paciente/estatística & dados numéricos , Seleção de Pacientes , Estudos Prospectivos , Medição de Risco , Resultado do Tratamento
11.
Ugeskr Laeger ; 176(43)2014 Oct 20.
Artigo em Dinamarquês | MEDLINE | ID: mdl-25353681

RESUMO

This is a case report of soft tissue infection with the marine bacterium Shewanella algae that is rare in Denmark. The patient was a 43-year-old male and he was treated surgically for Haglund's heel, a bony protrusion at the calcaneus. After clinical healing the patient suffered a rupture of the Achilles tendon, which was treated surgically as well. The post-operative healing process proved to be protracted with a number of surgical wound revisions being necessary. A microbiology culture showed the presence of S. algae and after proper antibiotic treatment the patient recovered quickly.


Assuntos
Infecções por Bactérias Gram-Negativas/microbiologia , Shewanella/isolamento & purificação , Infecção da Ferida Cirúrgica/microbiologia , Tendão do Calcâneo/patologia , Tendão do Calcâneo/cirurgia , Adulto , Antibacterianos/uso terapêutico , Calcâneo/patologia , Calcâneo/cirurgia , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Infecções por Bactérias Gram-Negativas/patologia , Humanos , Masculino , Infecção da Ferida Cirúrgica/tratamento farmacológico , Infecção da Ferida Cirúrgica/patologia , Doença Relacionada a Viagens
12.
Spine J ; 3(4): 285-8, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14589188

RESUMO

BACKGROUND CONTEXT: The biological factors determining a successful spinal fusion have not yet been fully determined. PURPOSE: To determine the influence of graft cell vigor on fusion rate and fusion mass using in vitro osteoblast proliferation as a predictor. STUDY DESIGN: Animal study randomizing to posterolateral fusion with autograft with or without pedicle-screw instrumentation. PATIENT SAMPLE: Twenty adult Göttingen mini-pigs. OUTCOME MEASURES: Fusion rate measured both with X-ray and computed tomography (CT) as well as amount of fusion mass determined with three-dimensional CT. METHODS: Animals underwent posterolateral fusion with autograft either with or without pedicle-screw instrumentation. Additional graft was harvested for osteoblastlike cell culture. Cells were counted after 3 weeks, and their proliferative capacity was correlated to fusion rate and fusion amount. RESULTS: Cell count was significantly higher in the fused animals (p<.011). Furthermore, a tendency toward a positive correlation to fusion mass amount was observed (p<.091). CONCLUSIONS: The achievement of a solid spinal fusion using autograft is related to properties of the bone-forming cells in the graft and fusion bed. Most likely it is the number of cells and not their proliferative capacity that is the most important factor.


Assuntos
Vértebras Lombares/cirurgia , Osteoblastos/citologia , Fusão Vertebral/veterinária , Animais , Parafusos Ósseos , Transplante Ósseo , Contagem de Células , Divisão Celular/fisiologia , Células Cultivadas , Feminino , Previsões , Laminectomia/veterinária , Vértebras Lombares/diagnóstico por imagem , Osteoblastos/fisiologia , Fusão Vertebral/instrumentação , Fusão Vertebral/métodos , Porco Miniatura , Tomografia Computadorizada por Raios X/veterinária , Transplante Autólogo , Resultado do Tratamento
14.
Acta Orthop Scand ; 74(4): 490-6, 2003 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-14521304

RESUMO

We investigated the influence of three peroperative handling techniques on the quality of autogenous bone graft by means of osteoblast-like cell metabolism in vitro. Cancellous bone was harvested from the iliac crest of 12 4-month-old female pigs. Osteoblast-like cell cultures were established, using the tissue-explant method: (1) immediately after harvest of bone, (2) after storage of bone in saline at room temperature for 2 hours and (3) after "dry" storage of bone at room temperature for 2 hours. Proliferation was assessed by 3H-thymidine incorporation. Differentiation was assessed by alkaline phosphatase activity and procollagen I production (PICP). We found that osteoblast-like-cell proliferation was higher, when cultures were started shortly after harvesting of bone, or else stored in saline for 2 hours, as compared to bone left "to dry" for 2 hours. Basal alkaline phosphatase and PICP production did not differ in the three groups. These in vitro results suggest the superiority of harvest of autogenous bone graft shortly before the grafting procedure, or else temporary storage of the graft in saline for up to 2 hours.


Assuntos
Transplante Ósseo/métodos , Osteoblastos/metabolismo , Preservação de Tecido/métodos , Coleta de Tecidos e Órgãos/métodos , Animais , Divisão Celular/fisiologia , Células Cultivadas , Feminino , Ílio/citologia , Imuno-Histoquímica , Modelos Animais , Osteoblastos/fisiologia , Cuidados Pré-Operatórios/métodos , Probabilidade , Sensibilidade e Especificidade , Estatísticas não Paramétricas , Suínos , Transplante Autólogo
15.
Acta Orthop Scand ; 74(6): 730-6, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14763707

RESUMO

In vitro cultures of human primary osteoblast-like cells provide a model for studying cellular mechanisms associated with human bone biology. We investigated in vitro osteoblast-like cell metabolism as a method for predicting the occurrence of spinal fusion in the individual patient. A bone biopsy was taken from the iliac crest of 50 patients, median age 49 (23-77) years, who were undergoing lumbar spine fusion. First-passage osteoblast-like cells were established by the bone-tissue-explant method. We then estimated 3H-thymidine incorporation, alkaline phosphatase activity and procollagen I production. Fusion rates were evaluated at the 1-year follow-up. Primary human osteoblast-like cell cultures showed an age-dependent decline in their capacity for cellular outgrowth and expression of alkaline phosphatase, which suggested a useful biological response pattern of the osteoblast culture. However, such cultures were unsatisfactory as an in vitro tool for predicting fusion capacity.


Assuntos
Osteoblastos/metabolismo , Fusão Vertebral , Adulto , Idoso , Fosfatase Alcalina/metabolismo , Células Cultivadas , Colágeno Tipo I/metabolismo , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Fumar , Resultado do Tratamento
16.
Eur Spine J ; 11(5): 476-81, 2002 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-12384757

RESUMO

Intervertebral disc has been shown to be related to low back pain and nerve root injury in pathologic conditions. However, little is known about its influence on spinal fusion. With the development of minimal invasive operations, such as laparoscopic anterior spinal fusion with cages, insufficient discectomy may occur. With its inflammatory properties, the residue nucleus pulposus may have an effect on spinal fusion. In this study, a two-level lumbar spine interbody fusion (L3/4, L5/6) with a Brantigan cage was performed on ten Danish Landrace pigs. Each level was randomly assigned to one of the following methods: (1) implantation of Brantigan cage filled with autogenous iliac crest bone graft, or (2) implantation of Brantigan cage filled with a mixture of autograft and the nucleus pulposus tissue harvested from the disc level in which it was to be inserted. Each level was stabilized with two staples. The pigs were followed for 12 weeks in the same standardized condition. After sacrifice, the lumbar spines were taken out, and plain X-ray, computed tomographic (CT) scanning and histomorphometry were performed to study the fusion mass inside the cages. From plain radiographs, new bone formation could be seen inside and around the cage. CT evaluation showed that the nucleus pulposus level had a 20% (2/10) fusion rate, while the pure autograft level had a 70% (7/10) fusion rate ( P=0.07). The histological fusion rate was even lower in the nucleus pulposus level (10%), and was significantly different from the autograft level (70%, P=0.02). Histomorphometric parameters of new bone formation, bone marrow space and fibrous tissue differed significantly between the two levels ( P=0.04; P=0.02; P=0.04 respectively). We conclude that when nucleus pulposus is mixed with the autogenous bone graft, it can delay or decrease the bone formation inside the cage, thus influencing the final fusion.


Assuntos
Transplante Ósseo/métodos , Discotomia Percutânea/efeitos adversos , Disco Intervertebral/transplante , Vértebras Lombares/cirurgia , Fusão Vertebral/métodos , Animais , Transplante Ósseo/efeitos adversos , Feminino , Sobrevivência de Enxerto/fisiologia , Fixadores Internos/efeitos adversos , Fixadores Internos/normas , Fixadores Internos/estatística & dados numéricos , Disco Intervertebral/metabolismo , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/crescimento & desenvolvimento , Modelos Animais , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/fisiopatologia , Complicações Pós-Operatórias/prevenção & controle , Radiografia , Fusão Vertebral/efeitos adversos , Suínos , Transplante Autólogo/efeitos adversos , Transplante Autólogo/métodos , Resultado do Tratamento
17.
Spine (Phila Pa 1976) ; 27(12): 1269-77, 2002 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-12065973

RESUMO

STUDY DESIGN: A prospective randomized clinical study with a 5-year follow-up. OBJECTIVES: To analyze the long-term effect of supplementary transpedicular screw fixation on reoperation rate and functional outcome. SUMMARY OF BACKGROUND DATA: Within the past few years the benefit of supplemental pedicle screw fixation has been questioned as a standard procedure in lumbar spinal fusion surgery. The long-term effect of supplemental pedicle screw fixation is still unknown. METHODS: From 1992 through 1994 a total of 129 patients with severe chronic low back pain were randomly selected for either supplemental pedicle screw fixation (instrumented) or no pedicle screw instrumentation (noninstrumented) posterolateral spinal fusion. The Dallas Pain Questionnaire, Low Back Pain Rating Scale, and a questionnaire concerning work status assessed the outcome. RESULTS: A 5-year follow-up of 93% showed that the instrumented group had a 25% reoperation rate (removal of instrumentation with and without second fusion) compared with a reoperation rate of 14% in the noninstrumented group (fusion and decompression) (P < 0.03). A total of 51% were capable of working after 5 years compared with 40% before surgery. There was no difference in work capacity between the two groups at any point of observation. Overall, there was no significant difference between the instrumented and noninstrumented groups in regard to functional outcome as measured by both the Dallas Pain Questionnaire and Low Back Pain Rating Scale. When analyzing diagnostic subgroups at the 5-year follow-up, patients with isthmic spondylolisthesis had a significantly better outcome by use of a posterolateral fusion without supplemental instrumentation compared with an instrumented fusion (P < 0.03). However, patients with primary degenerative instability improved significantly more when instrumentation supported the posterolateral spinal fusions (P < 0.02). To the question "was it worth it?" 67% answered "yes" in the instrumented group whereas 70% did so in the noninstrumented groups (not significant). CONCLUSION: The long-term functional outcome of posterolateral spinal fusion improved significantly for boththose with and without pedicle screw instrumentation, with a global 70% satisfaction reported by the patients. Patients with isthmic spondylolisthesis Grades 1 and 2 with noninstrumented fusion had superior long-term outcomes after posterolateral spinal fusion in comparison with an instrumented fusion. In contrast, patients diagnosed as having primary degenerative instability improved significantly when the posterolateral fusion was supported by instrumentation. In actuality, pedicle screw instrumentation increased reoperation rate compared with noninstrumented posterolateral fusion.


Assuntos
Parafusos Ósseos , Vértebras Lombares/cirurgia , Fusão Vertebral/instrumentação , Adulto , Idoso , Emprego , Feminino , Seguimentos , Humanos , Dor Lombar/patologia , Dor Lombar/prevenção & controle , Vértebras Lombares/patologia , Masculino , Pessoa de Meia-Idade , Pacientes Desistentes do Tratamento , Estudos Prospectivos , Índice de Gravidade de Doença , Fumar , Fusão Vertebral/métodos , Estatística como Assunto , Inquéritos e Questionários , Fatores de Tempo , Resultado do Tratamento , Local de Trabalho
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