RESUMO
The aim of this study was to compare whether the newest TKA prosthesis (Persona) gives improved clinical outcomes due its more anatomical design in comparison to older prostheses (balanSys). This study included a total of 89 patients planned for TKA from June 2018 to September 2019. Outcomes such as Knee Injury and Osteoarthritis Outcome Score (KOOS), range of motion (ROM), numeric pain rating scale (NRS), analgesics and alignment were recorded next to patient characteristics and complications. Our results showed a significant improvement in NRS, ROM and functional scores postoperatively compared to preoperatively for both the Persona and the balanSys implants. Although the flexion ROM for the Persona group was higher at 6 and 12 months postoperative compared to the balanSys, this was mainly a regaining of the preoperative ROM. Throughout all timepoints, there were no statistically significant differences observed in NSAID and opioid usage between the balanSys and Persona groups. Both implants are safe and efficient to use in the treatment of knee osteoarthritis. Although Persona had an improved postoperative flexion, this did not have an impact on any of the patient-reported outcomes.
Assuntos
Artroplastia do Joelho , Prótese do Joelho , Osteoartrite do Joelho , Humanos , Artroplastia do Joelho/métodos , Estudos Prospectivos , Osteoartrite do Joelho/cirurgia , Desenho de Prótese , Amplitude de Movimento Articular , Dor/etiologia , Articulação do Joelho/cirurgia , Resultado do TratamentoRESUMO
We report the case of a man whose high-density lipoprotein cholesterol (HDL-C) and the ratios of total cholesterol to HDL-C and low-density lipoprotein cholesterol to HDL-C worsened dramatically during pravastatin treatment. After 3 years, pravastatin was replaced by fenofibrate. The result was spectacular. The HDL-C increased to at least twice the level obtained during pravastatin.
Assuntos
Anticolesterolemiantes/efeitos adversos , Pravastatina/efeitos adversos , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Humanos , Hipercolesterolemia/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Falha de TratamentoRESUMO
The Nazlet Khater 4 site (Nile Valley, Upper Egypt) is located on one of the small wadi- interfluves in the lower desert near the steep cliffs bordering the western Nile Valley edge (Fig. 1). We have previously reported the excavation of an early Upper Palaeolithic blade industry at this site, although blade industries in the Nile Valley had only been known to occur since 18,000 yr ago. The 1982 excavation reported here confirms that Nazlet Khater 4 is a chert mining site with a complex extraction strategy, going back 33,000 yr. A nearby grave contained a skeleton of a man in the extended position. We show that the cranial morphology is anatomically modern with archaic characteristics such as a very robust mandible. There is evidence that the skeleton has a similar age to that of the mining site.
