RESUMO
We report three different cases in location with an original occurrence in the oesophagus. The gross appearance showed polypoid pedonculated masses with a whitish cut surface, arising from the submucosa. On microscopic examination, the tumor consisted of spindle cell dispersed in a loose fibromyxoid stroma containing numerous blood vessels and inflammatory cells with abundant eosinophils. At immunohistochemistry, the cells were strongly positive for CD34. Inflammatory fibroid polyp is a rare benign lesion of the gastro-intestinal tract. The pathogenesis of this lesion remains throat and unclear. Diagnosis on biopsy is difficult with various histologic pattern and because the inflammatory fibroid polyp share common pathologic features with digestive spindle cells tumor.
Assuntos
Neoplasias Esofágicas/patologia , Pólipos Intestinais/patologia , Leiomioma/patologia , Divisão Celular , Tecido Conjuntivo/patologia , Edema/patologia , Eosinófilos/patologia , Neoplasias Esofágicas/genética , Neoplasias Esofágicas/cirurgia , Feminino , Humanos , Inflamação/patologia , Mucosa Intestinal/patologia , Mucosa Intestinal/cirurgia , Pólipos Intestinais/genética , Pólipos Intestinais/cirurgia , Leiomioma/genética , Leiomioma/cirurgia , Masculino , Pessoa de Meia-Idade , PoliploidiaAssuntos
Fibroma/patologia , Neoplasias Cutâneas/patologia , Antígeno 12E7 , Antígenos CD/análise , Moléculas de Adesão Celular/análise , Cromossomos Humanos Par 17 , Cromossomos Humanos Par 22 , Fibroma/genética , Fibroma/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/cirurgia , Translocação Genética , Resultado do TratamentoRESUMO
Acral myxoinflammatory fibroblastic sarcoma is a rare low-grade malignant soft tissue tumor, usually observed in the extremities of middle-aged adults. We report two cases which occurred in the thumb and knee of middle-aged women. Both tumors showed a multinodular architecture, with cellular areas, occasional foci of hyalinized fibrosis, and hypocellular areas with a myxoid background. Various neoplastic cells were identified including spindled or rounded epithelioid cells and occasional bizarre giant cells, morphologically mimicking Reed-Sternberg cells or ganglion cells. Tumor cells were strongly immunoreactive for vimentin, and variably positive for CD68 and CD34. Both tumors were completely resected and patients were free of disease without any further treatment after a mean follow-up of 14 months.
