RESUMO
PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported. The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously. Six of the patients were no longer receiving vigabatrin. METHODS: The central and peripheral fields were examined with the Humphrey Visual Field Analyzer. Full visual electrophysiology, including flash electroretinography (ERG), pattern electroretinography, multifocal ERG using the VERIS system, electro-oculography, and flash and pattern visual evoked potentials, was undertaken. RESULTS: Seven patients showed marked visual field constriction with some sparing of the temporal visual field. The eighth exhibited concentric constriction. Most electrophysiological responses were usually just within normal limits; two patients had subnormal Arden electro-oculography indices; and one patient showed an abnormally delayed photopic b wave. However, five patients showed delayed 30-Hz flicker b waves, and seven patients showed delayed oscillatory potentials. Multifocal ERG showed abnormalities that sometimes correlated with the visual field appearance and confirmed that the deficit occurs at the retinal level. CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy. The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.
Assuntos
Eletroculografia/estatística & dados numéricos , Eletrorretinografia/estatística & dados numéricos , Epilepsia/tratamento farmacológico , Potenciais Evocados Visuais/fisiologia , Doenças Retinianas/induzido quimicamente , Doenças Retinianas/diagnóstico , Vigabatrina/efeitos adversos , Transtornos da Visão/induzido quimicamente , Transtornos da Visão/diagnóstico , Campos Visuais/efeitos dos fármacos , Adulto , Eletrofisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes de Campo Visual/estatística & dados numéricos , Campos Visuais/fisiologiaRESUMO
OBJECTIVE: To estimate the prevalence of visual field defects in patients taking the anticonvulsant drug vigabatrin and to characterise the features of visual dysfunction found. METHODS: Thirty three unselected patients attending neurology and epilepsy clinics were identified as taking vigabatrin and asked to attend for neuro-ophthalmic evaluation. A control group of 16 patients with epilepsy unexposed to vigabatrin was also evaluated. Visual fields were examined by static perimetry using a Humphrey field analyser. Patients underwent detailed ophthalmic examination, various blood tests, and brain MRI where necessary. Visual evoked responses (VERs), electro-oculograms (EOGs), and electroretinograms (ERGs) were recorded. RESULTS: Of 31 assessable patients treated with vigabatrin, 16 (52%) had definitely abnormal visual fields, nine (29%) had fields that were inconclusive, four (13%) had normal fields, and two (6%) proved unable to cooperate with testing. In four patients some plausible cause was found for the field abnormality leaving 12 patients (39%) in whom a definite bilateral field defect was found, possibly caused by vigabatrin treatment. Of 16 control patients none had definitely abnormal fields, 12 (75%) had normal fields, and four (25%) had fields that were inconclusive. The field defects associated with vigabatrin treatment showed a characteristic pattern of concentric peripheral field loss with temporal and macular sparing. The VERs and ERGs were normal. The EOG Arden Index was reduced in patients taking vigabatrin, although this returned towards normal when vigabatrin was stopped, even in the presence of persistent field defects. Multifocal ERGs recorded in two patients were abnormal, showing marked reduction in amplitude of the peripheral focal ERG. CONCLUSIONS: Treatment with vigabatrin was associated with a high prevalence of peripheral visual field defects. This seemed to be the result of a toxic effect of vigabatrin on the retina and seemed to persist if the drug was withdrawn.
Assuntos
Anticonvulsivantes/efeitos adversos , Epilepsia/tratamento farmacológico , Transtornos da Percepção/induzido quimicamente , Vigabatrina/efeitos adversos , Campos Visuais/efeitos dos fármacos , Percepção Visual/efeitos dos fármacos , Adolescente , Adulto , Idoso , Encéfalo/anatomia & histologia , Encéfalo/diagnóstico por imagem , Eletroculografia , Eletrorretinografia , Potenciais Evocados Visuais , Feminino , Fixação Ocular , Humanos , Masculino , Pessoa de Meia-Idade , Retina/efeitos dos fármacos , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X , Acuidade Visual/efeitos dos fármacosAssuntos
4-Aminobutirato Transaminase/antagonistas & inibidores , Anticonvulsivantes/efeitos adversos , Transtornos da Visão/induzido quimicamente , Campos Visuais , Ácido gama-Aminobutírico/análogos & derivados , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Vigabatrina , Ácido gama-Aminobutírico/efeitos adversosRESUMO
A 55-year-old woman had paroxysms of vertigo and visual blurring associated with complex combined torsional, horizontal, and vertical nystagmus. These episodes occurred regularly at 2-minute intervals, each attack lasting for 15 seconds. Between attacks, there was a much finer asymptomatic nystagmus whose components were in the opposite direction to those associated with the paroxysmal attacks. A brain MRI revealed an arteriovenous malformation in close proximity to the left vestibular nucleus, with evidence of previous bleeding. Caloric testing demonstrated a left-sided vestibular paresis. We suggest that neurons in this patient's damaged left vestibular nucleus are usually underactive but regularly produce pathologic brief bursts of hyperactivity causing episodic reversal and gross exacerbation of her resting nystagmus. Treatment with low-dose carbamazepine was successful in abolishing both the paroxysms of nystagmus and the symptoms of vertigo and visual disturbance.
Assuntos
Malformações Arteriovenosas/diagnóstico , Encéfalo/patologia , Nistagmo Patológico/fisiopatologia , Vertigem/fisiopatologia , Malformações Arteriovenosas/patologia , Atrofia , Cerebelo/patologia , Artérias Cerebrais/anormalidades , Veias Cerebrais/anormalidades , Movimentos Oculares , Feminino , Lateralidade Funcional , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Nistagmo Patológico/diagnóstico , Nistagmo Patológico/patologia , Vertigem/diagnóstico , Vertigem/patologiaRESUMO
The oculomotor smooth pursuit system is driven by the slip of the target image upon the retina arising from errors in matching eye and target velocities. However, pursuit of an object moving against a structured background causes most retinal flow to be in the direction opposite to target movement. Central mechanisms allow these distracting signals to be overridden effortlessly. To isolate the anatomical substrate of this capacity we studied the effect of the presence of a structured background upon smooth pursuit in 26 patients with focal cerebral lesions. In normal control subjects, studies confirmed that a background has little effect upon pursuit. Eye movements were recorded by the scleral search coil method or by infra-red oculography. The target was a bright spot moving horizontally in a triangular waveform of amplitude +/- 11.25 degrees visual angle, at either 10, 20, 30 or 36.5 degrees/s. Data were collected in darkness and with a structured background: 14 patients showed a significant reduction of gain with a structured background, while the remaining 12 showed little or no effect. Comparison of the location of the cerebral lesions in these two groups suggested that lesions in the inferior parietal cortex (area 40) or in white matter containing parieto-frontal connections result in disruption of pursuit in the presence of a background.
Assuntos
Encefalopatias/fisiopatologia , Acompanhamento Ocular Uniforme , Lobo Temporal/fisiopatologia , Adulto , Idoso , Humanos , Pessoa de Meia-Idade , Reconhecimento Visual de ModelosAssuntos
Ataxia Cerebelar/etiologia , Transtornos Cognitivos/etiologia , Febre/complicações , Esclerose Múltipla/complicações , Adulto , Axônios , Doenças Desmielinizantes , Potenciais Evocados Visuais , Feminino , Humanos , Imunoglobulina G/líquido cefalorraquidiano , Imageamento por Ressonância Magnética , Esclerose Múltipla/diagnósticoRESUMO
A 49 year old woman reported an attack of transient neurological dysfunction associated with unilateral headache. A prominent feature of the aura was a period of complete achromatopsia, so that the visual scene was experienced in monochrome. The episode developed to include features of prosopagnosia and spatial agnosia before resolving completely. Other episodes of transient neurological dysfunction followed at regular intervals until prophylactic antimigrainous therapy was initiated. Four vessel cerebral angiography and MRI of the brain were normal. Possible causes of this unusual migrainous aura are discussed with reference to current concepts of cerebral localisation.
Assuntos
Defeitos da Visão Cromática/fisiopatologia , Transtornos de Enxaqueca/fisiopatologia , Defeitos da Visão Cromática/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Transtornos de Enxaqueca/complicaçõesRESUMO
Evidence is presented that the human visual system contains broad-band mechanisms capable of encoding the spatial phase relationship between a fundamental spatial frequency and higher frequencies up to its third harmonic. Compounds of a fundamental and its harmonics above the third become progressively more difficult to discriminate by means of phase information alone. Measurements were also made of the amount of spatial summation found in various detection and phase discrimination tasks using simple or compound gratings composed of a fundamental frequency (F) and its third harmonic (3F). A task requiring the discrimination of the phase relationship between a low contrast (F) and a high contrast (3F) shows less spatial summation than does a task requiring the detection of the (F) component by itself. A simple model is advanced to account for these results qualitatively. The model is based upon the hypothesis that the human visual system analyses the retinal image in patches of a range of sizes and that phase relationships may be discerned only between components that are detected by different elements of the same patch mechanism.
Assuntos
Percepção Espacial/fisiologia , Discriminação Psicológica/fisiologia , Humanos , Modelos Neurológicos , Reconhecimento Visual de Modelos/fisiologia , Limiar Sensorial/fisiologia , Acuidade VisualRESUMO
Anomalies in the contrast sensitivity functions of amblyopes are usually insufficient to account for the degree of visual deficit found in more complex tasks. Evidence is presented that many of the defects of amblyopic vision arise from a failure to encode the spatial phase relationships between detectable components of different spatial frequencies. It appears that visual processing in amblyopia occurs over a more truncated frequency range than is implied by detection experiments.
Assuntos
Ambliopia/fisiopatologia , Percepção Visual/fisiologia , Humanos , Modelos Neurológicos , Reconhecimento Visual de Modelos/fisiologia , Psicofísica , Retina/fisiopatologia , Percepção Espacial/fisiologiaRESUMO
Previous work has shown that anomalies in the contrast sensitivity functions of amblyopes are often insufficient to explain the degree of visual deficit in more complex tasks. Our stimuli were compound gratings composed of a fundamental and its third harmonic, added in either square-wave or triangle-wave phase. At medium to high spatial frequencies we find that many amblyopes, unlike normal observers, are unable to distinguish between such gratings which have identical power spectra, but different phase spectra. In this frequency range they can, however, easily distinguish between a compound grating and its fundamental component alone. It seems that in amblyopia visual processing occurs over a more truncated frequency range than is implied by detection experiments. Various explanations of this observation are considered.