RESUMO
P450s (cytochrome P450 mono-oxygenases) are a superfamily of haem-containing mono-oxygenase enzymes that participate in a wide range of biochemical pathways in different organisms from all of the domains of life. To facilitate their activity, P450s require sequential delivery of two electrons passed from one or more redox partner enzymes. Although the P450 enzymes themselves show remarkable similarity in overall structure, it is increasingly apparent that there is enormous diversity in the redox partner systems that drive the P450 enzymes. This paper examines some of the recent advances in our understanding of the biodiversity of the P450 redox apparatus, with a particular emphasis on the redox systems in the pathogen Mycobacterium tuberculosis.
Assuntos
Sistema Enzimático do Citocromo P-450/química , Sistema Enzimático do Citocromo P-450/metabolismo , Proteínas de Bactérias/química , Proteínas de Bactérias/genética , Proteínas de Bactérias/metabolismo , Sítios de Ligação , Biodiversidade , Sistema Enzimático do Citocromo P-450/genética , Transporte de Elétrons , Ferredoxinas/química , Ferredoxinas/metabolismo , Flavina-Adenina Dinucleotídeo/metabolismo , Flavodoxina/química , Flavodoxina/metabolismo , Genoma Bacteriano , Modelos Moleculares , Mycobacterium tuberculosis/enzimologia , Mycobacterium tuberculosis/genética , NADP/metabolismo , Oxirredução , Conformação ProteicaRESUMO
A survey was conducted on 1,012 people in the Oxford Region to determine their general attitude to doctors' age, sex and colour and to various aspects of doctor/patient communication. Results indicate that whereas there were no prejudices about appearance there was a significant degree of dissatisfaction with information given by doctors in general and hospital doctors in particular.
