Open reduction and internal fixation of paediatric maxillozygomatic complex fractures: An 11-year multicentric retrospective study.

BACKGROUND/AIM: Paediatric maxillozygomatic complex (MZC) fractures are uncommon, and there is a scarcity of data regarding their surgical treatment. The aim of this study was to analyse choices and outcomes of open reduction and internal fixation (ORIF) for MZC fractures among 14 maxillofacial centers around the world. MATERIALS AND METHODS: This multicentric retrospective observational study included patients ≤16 years of age with quadripod MZC fractures treated with ORIF from January 2011 and December 2022. The following data were collected: age, gender, dentition stage (deciduous, mixed, and permanent), cause of injury, type of fracture, surgical approach, site of osteosynthesis (infraorbital rim, zygomaticomaxillary buttress, frontozygomatic, and zygomaticotemporal sutures), material (titanium or resorbable) and number of plates used, and outcome. The minimum follow-up was 6 months. Statistical analyses were performed with Fisher's exact test or chi-squared test, as appropriate. RESULTS: Sixty-four patients (mean age, 12.3 years) with quadripod MZC fractures were included. Seventy-two percent of patients received a single-point fixation. The zygomaticomaxillary buttress was the most common site for fixation, both in single-point and two-point fixation schemes, especially in combination with the frontozygomatic suture. Increasing age was associated with a higher rate of plate removal (p < .001). Postoperative complications included 5 (7.8%) cases of wound infections, 2 (3.1%) infraorbital paraesthesia, 1 (1.6%) ectropion. Residual facial asymmetry was found in 5 (7.8%) patients and was not associated with the type of fixation (p > .05). CONCLUSIONS: This study highlights the possibility of using ORIF, even with a single point of fixation, for the treatment of displaced quadripod MZC fractures in the paediatric population. The zygomaticomaxillary buttress was the preferred site of fixation and allowed for adequate stabilization with no external scars and a low risk of tooth damage. Future prospective studies with long-term follow-up are needed to establish definitive surgical protocols and clarify the surgical decision-making.

PROPHYLACTIC ANTIBIOTICS DURING THE IMPLANT PROSTHETIC PHASE MAY NOT SUBSTANTIALLY DECREASE THE INCIDENCE OF INFECTIOUS COMPLICATIONS.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Does the Prosthetic Phase of Dental Implants Justify the Prescription of Preventive Antibiotics in Healthy Patients? A Systematic Review. Salgado-Peralvo AO, Uribarri A, Peña-Cardelles JF, Kewalramani N, Rodríguez JLG, Velasco-Ortega E. J Oral Implantol. 2023 Feb 1;49(1):93-101. SOURCE OF FUNDING: The authors declared that no funding was received to support the study. TYPE OF STUDY/DESIGN: Systematic review.

The foundation for future education, teaching, training, learning, and performing infrastructure - The open interoperability conceptual framework approach.

The proliferation of Information and Communication Technologies (ICT) in Education, Teaching, Training, Learning, and the operational application (Performing) of acquired knowledge, skills, and competencies in contemporary social environments has directly influenced the transformation of early Networked Learning (NL) concepts into a Global Learning Infrastructure. Creating cooperative/collaborative stakeholders networks composed of learning subjects, objects, and competencies consumers, exposes the significant potential for gaining overall social progress. The main challenging obstacles of such globalization are: embedding semantics into the competence credentials carriers, trusted dissemination of verifiable competence tokens, the heterogeneous ontologies mapping, and sustainable service delivery infrastructure. The mainstream motivation of our research is the specification and development of a conceptual framework that fosters the interoperability of different stakeholders, whether individual or institutional, to declare, share and maintain the representative collections of information resources related to the particular Education, Learning, Teaching, Training, and Performing (Research, Development, Production, and Service) endeavors. In this article, we have specified an open, heterogeneous, interoperable conceptual framework capable of orchestrating past, current, and future paradigms to foster building the foundations for comparative analysis and evaluation of traditional and nontraditional competency-building processes, joined with students' portfolio creation, dissemination, and management. It is a starting specification that would serve for the future: open, heterogeneous, cooperative/collaborative, service-oriented software framework specification and development.

In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys.

Due to the unique functional properties of shape memory alloys (SMAs) and current scientific interest in Cu-containing biomaterials, a continuously cast Cu-Al-Ni alloy in the form of rods has been investigated as a potential candidate for biomedical application. Additionally, the fact that Cu- complexes have an antitumour effect served as a cornerstone to develop more efficient drugs based on trace element complexes. In line with that, our study aimed to analyse the basic properties of the Cu-Al-Ni alloy, along with its anticancer properties. The detailed chemical analysis of the Cu-Al-Ni alloy was performed using XRF and SEM/EDX analyses. Furthermore, a microstructural and structure investigation was carried out, combined with hardness measurements using the static Vickers method. Observations have shown that the Cu-Al-Ni microstructure is homogeneous, with the presence of typical martensitic laths. XRD analysis confirmed the presence of two phases, ß' (monoclinic) and γ' (orthorhombic). The viability of osteosarcoma cells in contact with the Cu-Al-Ni alloy was evaluated using epifluorescence microscopy, while their morphology and attachment pattern were observed and analysed using a high-resolution SEM microscope. Biocompatibility testing showed that the Cu-Al-Ni alloy exerted a considerable antineoplastic effect.

Righting behaviour in the European pond turtle (Emys orbicularis): relations between behavioural and morphological lateralization.

Lateralization represents a key property of many behavioural traits, with the right and left sides of the brain providing different and integrative functions. Common ecological contexts where lateralization can be observed are foraging and predatory ones, where both visual and auditory lateralization may provide advantages such as faster response and increasing neural processing capacity. This is crucial in selecting a safe refuge during a predatory attack and may strongly affect the outcome of predator-prey interactions. For animals like turtles, a critical condition may occur when they are overturned on their own shell, which causes difficulties in breathing and thermoregulation, making them more vulnerable to predators. Therefore, the ability to right is a critical adaptive component related to survival in aquatic turtles, which has been observed to be lateralized. However, an overlooked feature of behavioural lateralization is its possible relationship with asymmetry in external morphology. Here we investigated this topic in freshwater European pond turtles Emys orbicularis, looking at a possible relation between lateralization in righting behaviour response and asymmetry in the shape of turtles' plastron and carapace. Righting performance (total time needed to completely turn) appeared to depend on shell shape. We found that none of the morphometric variables was related to a lateralization index calculated as the first side from which turtles tried to right. However, a strong negative correlation between the asymmetry index of plastron and the turning direction emerged, with more symmetric animals tending to turn to the right side.

The ontogeny of developmental buffering in lizard head shape.

Canalization and developmental stability (DS) are important organismal properties involved in determining the level of phenotypic variation. Ontogenetic patterns of phenotypic variance components can shed light on the mechanistic basis of developmental buffering (DB). Here, we analyze how individual FA and among-individual variation in head shape change in ontogenetic series of three lizard species raised in laboratory. The degree of asymmetry increased slightly with size, suggesting that developmental mechanisms hypothesized to correct for deviations either do not exist, or that their efficiency is truncated with increasing size. Alternatively, they may need the disturbance as a trigger. The relationship between asymmetry and age was complex, with asymmetry being stable across the age range in two species but increased with age in the third. Lack of congruence in ontogenetic patterns of asymmetry might be due to intrinsic differences in buffering mechanisms or a result of species-specific growth patterns. Head shape was shown to be equally canalized across both size and age range in all species, probably as a result of a balance between the buffering mechanisms and mechanisms generating variance. The patterns of symmetric and asymmetric head shape variation were highly correlated across species meaning that DS and canalization may rely on similar mechanisms.

Natural and anthropogenic radioactivity in the environment of Kopaonik mountain, Serbia.

To evaluate the state of the environment in Kopaonik, a mountain in Serbia, the activity concentrations of (4) K, (226)Ra, (232)Th and (137)Cs in five different types of environmental samples are determined by gamma ray spectrometry, and radiological hazard due to terrestrial radionuclides is calculated. The mean activity concentrations of natural radionuclides in the soil are higher than the global average. However, with an exception of two sampling locations, the external radiation hazard index is below one, implying an insignificant radiation hazard. Apart from (40)K, content of the natural radionuclides is predominantly below minimum detectable activities in grass and cow milk, but not in mosses. Although (137)Cs is present in the soil, grass, mosses and herbal plants, its specific activity in cow milk is below minimum detectable activity. Amongst the investigated herbal plants, Vaccinium myrtillus L. shows accumulating properties, as a high content of (137)Cs is detected therein. Therefore, moderation is advised in consuming Vaccinium myrtillus L. tea.

Effects of environmental disturbance on phenotypic variation: an integrated assessment of canalization, developmental stability, modularity, and allometry in lizard head shape.

When populations experience suboptimal conditions, the mechanisms involved in the regulation of phenotypic variation can be challenged, resulting in increased phenotypic variance. This kind of disturbance can be diagnosed by using morphometric tools to study morphological patterns at different hierarchical levels and evaluate canalization, developmental stability, integration, modularity, and allometry. We assess the effect of urbanization on phenotypic variation in the common wall lizard (Podarcis muralis) by using geometric morphometrics to assess disturbance to head shape development. The head shapes of urban lizards were more variable and less symmetric, suggesting that urban living is more likely to disturb development. Head shape variation was congruent within and across individuals, which indicated that canalization and developmental stability are two related phenomena in these organisms. Furthermore, urban lizards exhibited smaller mean head sizes, divergent size-shape allometries, and increased deviation from within-group allometric lines. This suggests that mechanisms regulating head shape allometry may also be disrupted. The integrated evaluation of several measures of developmental instability at different hierarchical levels, which provided in this case congruent results, can be a powerful methodological guide for future studies, as it enhances the detection of environmental disturbances on phenotypic variation and aids biological interpretation of the results.

Lizards from urban areas are more asymmetric: using fluctuating asymmetry to evaluate environmental disturbance.

The increase in human activities that leads to wildlife decline and species extinction poses an urgent need for simple indicators of environmental stress in animal populations. Several studies have suggested that fluctuating asymmetry (FA) can be an easy, direct measure of developmental instability because it is associated to environmental stress and, as such, it can be a useful indicator of population disturbance. We examined three different morphological traits in urban and rural populations of the common wall lizard (Podarcis muralis) to test whether anthropogenic disturbance causes an increase in FA. Compared to rural populations, urban ones showed higher levels of FA in all analyzed traits, thus providing evidence that FA can respond to anthropogenic disturbance. However, we also found significant differences in FA among traits, where femoral pores and subdigital lamellae, traits with a functional relevance, were more stable developmentally compared to supracilliar granules which have no evident function. Unsigned FA [abs(right-left)] exhibited significant, but weak, positive correlations among traits, indicating that developmental noise does not have a uniform effect across characters and thus questioning the view of developmental stability as an organism-wide property. The degree of signed FA (right-left) was more similar between structurally associated traits, possibly as an outcome of morphological integration. In conclusion, our results demonstrate that FA can be a reliable indicator of disturbance provided that it is analyzed on multiple traits simultaneously and examined at the population level.