RESUMO
An analyzed cohort consists of 50 pediatric patients with osteosarcoma receiving combined therapy in N. N. Petrov Research Institute for Oncology (1999-2010). Thirty nine of them had localized disease, 11 patients had distant metastases. The treatment scheme included neoadjuvant therapy with cisplatin and doxorubicin, surgical treatment and adjuvant therapy depended on initial response and could include cisplatin, doxorubicin, high-dose methotrexate, ifosfamide, etoposide. Four-year overall and relapse-free survival in children with localized disease was 74.3% and 69.2% accordingly. In 62% of patients were performed organ-preserving surgical interventions, in 22 patients was performed endoprosthetics, in 4 patients the defect was replaced by a bone autograft on a vascular bundle. The effectiveness of initial treatment and secondary endoprosthetics were analyzed. Six patients with lung metastases received normotermic lung chemoperfusion, 4 of them are alive and disease-free for 8 to 24 months.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/cirurgia , Neoplasias Pulmonares/tratamento farmacológico , Terapia Neoadjuvante/métodos , Procedimentos Ortopédicos/métodos , Osteossarcoma/tratamento farmacológico , Osteossarcoma/cirurgia , Adolescente , Neoplasias Ósseas/patologia , Transplante Ósseo , Quimioterapia do Câncer por Perfusão Regional , Criança , Cisplatino/administração & dosagem , Estudos de Coortes , Intervalo Livre de Doença , Doxorrubicina/administração & dosagem , Etoposídeo/administração & dosagem , Feminino , Humanos , Ifosfamida/administração & dosagem , Neoplasias Pulmonares/secundário , Masculino , Metotrexato/administração & dosagem , Osteossarcoma/secundário , Transplante Autólogo , Resultado do TratamentoRESUMO
In this study we present an analysis of our own data on computerized tomography (CT) employment in patients with gastrointestinal stromal tumors (GIST) and the review of the literature. The CT data for 21 patients with GIST was compared with operation and morphology data. Difficulties of GIST timely diagnostic are described.