RESUMO
Changes of neuromediators and their correction in the posttraumatic period after acute blood loss were studied experimentally in mongrel dogs. Survival of white rats was examined after heavy combined trauma during therapeutic use of exogenous cholinesterase and serotonin. Their use was studied clinically in patients with heavy combined trauma. The use of exogenous cholinesterase and serotonin in a complex of resuscitation measures permits stabilization of the functional state of the adrenal cortex and the cholinergic, adrenergic and serotoninergic systems.
Assuntos
Colinesterases/uso terapêutico , Neurotransmissores/sangue , Serotonina/uso terapêutico , Ferimentos e Lesões/sangue , Acetilcolina/sangue , Acetilcolinesterase/sangue , Córtex Suprarrenal/efeitos dos fármacos , Animais , Catecolaminas/sangue , Colinesterases/sangue , Cães , Humanos , Monoaminoxidase/sangue , Sistema Nervoso Parassimpático/efeitos dos fármacos , Ratos , Ressuscitação , Serotonina/sangue , Sistema Nervoso Simpático/efeitos dos fármacos , Ferimentos e Lesões/terapiaAssuntos
Neurotransmissores/sangue , Ressuscitação , Animais , Morte , Cães , Hemorragia/sangue , Hemorragia/terapia , Fatores de TempoRESUMO
Experiments on rats have demonstrated the effect of neurotransmitter function on the activity of the surfactant system and functioning area of the lung (FAL). Excess transmitters gave rise to activation of the lung surfactant system and increase in the FAL, whereas the deficiency of transmitters lowered surfactant activity and the area of the air-blood barrier.
Assuntos
Pulmão/efeitos dos fármacos , Neurotransmissores/farmacologia , Surfactantes Pulmonares/fisiologia , Glândulas Suprarrenais/efeitos dos fármacos , Animais , Droperidol/farmacologia , Epinefrina/farmacologia , Pulmão/fisiologia , Norepinefrina/farmacologia , Propranolol/farmacologia , Ratos , Receptores Colinérgicos/efeitos dos fármacos , Serotonina/farmacologia , Sistema Nervoso Simpático/efeitos dos fármacos , Triptofano/farmacologiaRESUMO
On the basis of experimental and clinical studies the authors recommend to use mebikar with promedol in complex with other drugs for the treatment of traumatic shock in the prehospital and hospital periods. It was found to substantially improve results of the antishock therapy.
Assuntos
Aminopirina/análogos & derivados , Biureias/administração & dosagem , Dipirona/administração & dosagem , Meperidina/análogos & derivados , Promedol/administração & dosagem , Choque Traumático/tratamento farmacológico , Equilíbrio Ácido-Base , Adolescente , Adulto , Idoso , Animais , Catecolaminas/sangue , Colinesterases/sangue , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monoaminoxidase/sangue , Ratos , Choque Traumático/sangueRESUMO
The effect of mebikar upon the course of traumatic shock was studied on the basis of experimental investigations and clinical observations. The authors have found a positive effect of the drug on indices of acid-base state, histostructure and cellular composition of the liver whose disturbance has a great pathogenetic significance in shock. The application of mebikar considerably improved the results of treatment in clinic and reduced lethality in experiment. It was supposed that the positive effect of the drug was associated with prevention of the development of circulatory disorders and with the maintenance of oxidation-reduction process and the histostructure of tissues.
Assuntos
Biureias/uso terapêutico , Compostos Bicíclicos com Pontes/uso terapêutico , Hidrocarbonetos Aromáticos com Pontes/uso terapêutico , Choque Traumático/tratamento farmacológico , Tranquilizantes/uso terapêutico , Equilíbrio Ácido-Base/efeitos dos fármacos , Adulto , Animais , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Humanos , Fígado/efeitos dos fármacos , Masculino , RatosAssuntos
Equilíbrio Ácido-Base , Mesentério/irrigação sanguínea , Receptores Colinérgicos/fisiologia , Choque Traumático/fisiopatologia , Acetilcolina/deficiência , Acetilcolina/farmacologia , Animais , Colinesterases/farmacologia , Masculino , Microcirculação/efeitos dos fármacos , Ratos , Receptores Colinérgicos/efeitos dos fármacos , Fatores de TempoAssuntos
Síndrome do Desconforto Respiratório/prevenção & controle , Adolescente , Adulto , Animais , Gatos , Cães , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Humanos , Hidrocortisona/uso terapêutico , Pessoa de Meia-Idade , Parassimpatomiméticos/uso terapêutico , Coelhos , Ratos , Respiração/efeitos dos fármacos , Síndrome do Desconforto Respiratório/tratamento farmacológico , Serotonina/uso terapêuticoRESUMO
A relationship between the state of adrenergic, cholinergic, and serotoninergic systems, on the one hand, and the acid-alkaline balance of the organism, on the other hand, was revealed in sharp and chronic experiments on dogs. A surplus of each of the mediators was accompanied by respiratory alkalosis, and its deficiency--by combined respiratory and metabolic acidosis.