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1.
Open Access J Contracept ; 14: 181-188, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38059115

RESUMO

Purpose: Adolescent pregnancy remains an important public health issue in the United States as it has profound health consequences for both mother and child. Evidence shows that improved contraception use is a critical factor in decreasing rates of adolescent pregnancy. In order to provide effective and engaging contraception education, it is important to understand adolescents' attitudes, questions, and misconceptions around the topic and its delivery. Methods: Two searches were conducted using PubMed. Articles were limited to those published in the last 10 years that were written in English. The first search was completed using the search terms "Adolescent attitudes on sex education in the United States", and resulted in 688 articles. The second search was completed using the search terms "Adolescent attitudes on contraception in the United States", and resulted in 840 articles. Articles including contraception but focusing more on HIV, pre-exposure prophylaxis (PrEP), LGBTQ+ health and practices, human papillomavirus (HPV) vaccination, and studies completed in other countries were excluded. Remaining articles were screened by the authors for inclusion, and articles were included if they addressed information on adolescent attitudes on both contraception for pregnancy prevention and sex education, including education by schools, community organizations, the media, peers, parents, and physicians. A total of 56 articles were included in the review. Results: The overwhelming theme that emerged from the review is that adolescents prefer comprehensive sex education in a safe space that allows for exploration and questioning. Adolescents want to ask their parents questions about sexual health without fear of punishment, and they desire the opportunity to learn from their physicians in a confidential environment. Conclusion: The foundation of effective sex education is a non-judgmental, confidential, and safe space where adolescents can ask questions. There are multiple resources that adolescents use to gather information and establish their preferences and attitudes.

2.
Clin Pediatr (Phila) ; 62(8): 935-936, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-36762799

RESUMO

As smartphone use in the office becomes more commonplace in medical practice, it is important to navigate this issue with grace, all while considering the legal, medical, and social implications, as well as the effect our behavior plays on our perceived bedside manner.


Assuntos
Aplicativos Móveis , Mídias Sociais , Humanos , Adolescente , Smartphone
3.
J Pediatr Adolesc Gynecol ; 33(5): 494-499, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32599169

RESUMO

STUDY OBJECTIVE: To examine the association between reproductive autonomy and adolescent receptivity toward long-acting reversible contraceptive (LARC) methods. DESIGN: A survey to assess sexual history and contraceptive practices/knowledge/attitudes was administered. Reproductive autonomy was measured with an adapted validated scale. SETTING: Adolescent medicine clinic in an urban academic medical center in the Midwestern United States. PARTICIPANTS: Girls ages 14-21 years who presented for well or contraceptive visits. INTERVENTIONS AND MAIN OUTCOME MEASURES: Primary outcome was a favorable rating toward the question "How much do you like the idea of LARC for yourself?" The primary independent variable was the reproductive autonomy decision-making subscale score (higher score indicating increased autonomy). RESULTS: Eighty-nine participants with a mean age of 16 years completed surveys. Almost all (92%) identified as African American. At study enrollment 56.2% were using Depo-Provera (Pfizer), 15.7% oral contraceptives, 3.4% implants, and 24.7% no method. Only 13.5% of participants liked the idea of LARC for themselves. The mean score on the decision-making subscale was 9 (range, 4-12). In bivariable analysis, age was associated with decision-making subscale score, but was not retained as a confounder in multivariable analysis. The odds of liking LARC decreased by 30% with each unit increase in the autonomy decision-making subscale score (odds ratio, 0.70; 95% confidence interval, 0.52-0.94; P = .02). CONCLUSION: Our findings suggest that adolescents with higher reproductive autonomy, measured according to their score on the decision-making subscale, were less likely to favor LARC. Further research should explore participants' perceptions of autonomy and the relational dynamics between adolescents and their parents/partners in contraceptive choice.


Assuntos
Comportamento de Escolha , Comportamento Contraceptivo/psicologia , Contracepção Reversível de Longo Prazo/psicologia , Adolescente , Negro ou Afro-Americano , Anticoncepcionais Femininos/administração & dosagem , Estudos Transversais , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Contracepção Reversível de Longo Prazo/métodos , Meio-Oeste dos Estados Unidos , Comportamento Sexual , Inquéritos e Questionários
4.
J Prim Care Community Health ; 10: 2150132719850384, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31130056

RESUMO

BACKGROUND: The prevalence of children with overweight or obese weight status in the United States is ~30%. Limited data exist on urban adolescents' self-reported health behaviors and their perceptions to healthy living. OBJECTIVES: To examine adolescents' self-reported health behaviors and perceived barriers and their associations with weight status. METHODS: In 2014, patients (ages 9+ years) were enrolled and completed health behavior surveys. Measurements were categorized into body mass index (BMI)-for-age percentiles. Adolescents without obesity (including underweight, healthy weight, and overweight) were compared against adolescents with obesity. RESULTS: A total of 132 adolescents were enrolled. The only factor that was statistically significant between the 2 weight groups was frequent exercise, which decreased odds of obesity by 0.34 (95% CI 0.13-0.93). Surprisingly, the odds of being obese increased significantly by 11.1 (95% CI 4.2-33.3) in those reporting trying to lose weight. CONCLUSIONS: To combat obesity, we reiterate the need for frequent exercise. Health care professionals should consider highlighting increased frequency of exercise and explore why adolescents with obesity were more inclined to report weight loss methods.


Assuntos
Negro ou Afro-Americano/estatística & dados numéricos , Dieta , Exercício Físico , Comportamentos Relacionados com a Saúde , Obesidade Infantil/epidemiologia , Adolescente , Assistência Ambulatorial , Cuidadores , Criança , Feminino , Humanos , Modelos Logísticos , Masculino , Medicaid , Análise Multivariada , Obesidade/epidemiologia , Pais , Características de Residência , Autorrelato , Estados Unidos/epidemiologia , População Urbana , Adulto Jovem
5.
Clin Pediatr (Phila) ; 58(1): 73-78, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30338699

RESUMO

Unintentional injuries are the leading cause of childhood mortality in the United States. Study aims included educating families about injury prevention and improving satisfaction with the waiting room experience. Two hundred caregivers with young children in the waiting room of an underserved pediatric primary care clinic participated in brief individual education sessions and received a toolkit containing small safety items and content highlighting age-appropriate safety topics. Participants completed 2 follow-up surveys, and most caregivers (94%) reported learning new information about injury prevention and thought that the intervention resulted in a better waiting room experience (91%). Of those who completed the 2-week follow-up survey (84%), 93.5% made changes at home and 42.7% bought new safety equipment. Injury prevention education can be effectively provided in the waiting room of a pediatric primary care clinic by improving reported caregiver safety knowledge and behaviors as well as satisfaction with the waiting room experience.


Assuntos
Instituições de Assistência Ambulatorial , Cuidadores/educação , Educação em Saúde/métodos , Pediatria/educação , Atenção Primária à Saúde , Ferimentos e Lesões/prevenção & controle , Adulto , Feminino , Humanos , Masculino , Avaliação de Programas e Projetos de Saúde , Inquéritos e Questionários
6.
J Pediatr Health Care ; 33(2): 178-185, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30190185

RESUMO

INTRODUCTION: The American Academy of Pediatrics recommends that adolescents be screened for mental health concerns and receive anticipatory guidance on stress management strategies. METHODS: Eighty-six participants (50 participants in the intervention group; 36 participants in the control group) participated in the study. Intervention group participants received training in diaphragmatic breathing, progressive muscle relaxation, and use of no-cost/low-cost exercise options. Biofeedback was used to guide relaxation. Subjective distress and heart rate variability was measured before and after the intervention. RESULTS: After the intervention, decreased levels of perceived stress and increased heart rate variability were reported compared with the control group. DISCUSSION: This study show that an integrated care model in a primary care setting is feasible and effective at improving stress management.


Assuntos
Saúde do Adolescente , Exercícios Respiratórios , Frequência Cardíaca/fisiologia , Atenção Primária à Saúde , Relaxamento/fisiologia , Estresse Psicológico/terapia , Adaptação Psicológica , Adolescente , Biorretroalimentação Psicológica , Exercícios Respiratórios/métodos , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Controle Interno-Externo , Masculino , Relaxamento Muscular/fisiologia , Avaliação de Programas e Projetos de Saúde , Relaxamento/psicologia , Autoeficácia , Estresse Psicológico/fisiopatologia , Estresse Psicológico/psicologia
7.
Case Rep Pediatr ; 2018: 6912351, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30123604

RESUMO

The most common cause of primary amenorrhea is congenital malformation of the Müllerian ducts, including Müllerian agenesis, also known as Mayer-Rokitansky-Küster-Hauser syndrome (MRKH). Most general gynecologists and primary care physicians who see female adolescents will encounter MRKH in their careers. We present the case of an adolescent with MRKH who reported secondary, instead of primary amenorrhea. We discuss the subtleties of diagnosing MRKH, especially when patient history may not always be accurate. Because MRKH had not been included in the differential diagnosis for delayed menses, this patient was initially misdiagnosed. Delayed diagnosis of MRKH may harm patients by delaying assessment of concomitant renal, skeletal, hearing, and cardiac defects, which might otherwise impact the treatment plan.

8.
Clin Pediatr (Phila) ; 57(6): 700-705, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-28969459

RESUMO

Thirty patients aged 11 to 21 years presenting in an adolescent medicine clinic received a one-time stress management intervention. The intervention included psychoeducation on the effect stress has on the body and the positive benefits of exercise, diaphragmatic breathing, and progressive muscle relaxation. The intervention also included use of a biofeedback game to aid in relaxation. Analyses revealed an association between higher levels of internalizing symptoms and perceived stress. A clinically significant decrease in subjective distress was endorsed at post-intervention. Ninety-three percent of participants reported that the intervention was helpful and that they had the requisite knowledge to practice stress management strategies outside of the clinic. At a one-week follow-up, of the 23 participants who were able to be reached, 22 wanted to participate in additional training. Findings suggest that a one-time stress management intervention can be beneficial for patients and easily incorporated within a primary care setting.


Assuntos
Psicologia do Adolescente , Estresse Psicológico/terapia , Adolescente , Criança , Humanos , Projetos Piloto , Serviços Urbanos de Saúde , Adulto Jovem
9.
Clin Pediatr (Phila) ; 56(8): 716-722, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27798386

RESUMO

This study explores how parents' intentions regarding vaccination prior to their children's visit were associated with actual vaccine acceptance. A convenience sample of parents accompanying 6-week-old to 17-year-old children completed a written survey at 2 pediatric practices. Using hierarchical logistic regression, for hospital-based participants (n = 216), vaccine refusal history ( P < .01) and vaccine decision made before the visit ( P < .05) explained 87% of vaccine refusals. In community-based participants (n = 100), vaccine refusal history ( P < .01) explained 81% of refusals. Over 1 in 5 parents changed their minds about vaccination during the visit. Thirty parents who were previous vaccine refusers accepted current vaccines, and 37 who had intended not to vaccinate choose vaccination. Twenty-nine parents without a refusal history declined vaccines, and 32 who did not intend to refuse before the visit declined vaccination. Future research should identify key factors to nudge parent decision making in favor of vaccination.


Assuntos
Tomada de Decisões , Conhecimentos, Atitudes e Prática em Saúde , Pais/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Vacinação/psicologia , Vacinação/estatística & dados numéricos , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino
10.
Int J Pediatr ; 2016: 4632628, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27795715

RESUMO

This study examined whether the presence of the father of the baby (FOB) at the first prenatal ultrasound study (US) visit of pregnant adolescents and young adults (AYA) is a marker for improved pregnancy outcomes. Charts of 400 pregnant AYA aged 14-22 years seen at an academic maternity hospital were assessed retrospectively for support persons brought to prenatal US visits. Logistic regression analysis was used to examine the association between FOB presence and gestational age and birth weight. Of 400 charts with support person recorded, 298 charts with first US visit data, singleton birth, and complete gestational data available were analyzed. FOB was present at 30.2% of visits, while the parent of the mother was present at 34.2% of visits. With FOB present, 3.3% of infants were born preterm (gestational age < 37 weeks) compared with 10.5% of infants with FOB absent (p = 0.04). Patients with FOB present also had significantly earlier gestational age at the first US visit (15 weeks) than those who did not (19 weeks; p = 0.02). For AYA, the presence of FOB at initial prenatal US visits is a predictor of improved pregnancy outcome and likely represents increased support during the pregnancy.

11.
Int J Pediatr ; 2016: 8487378, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-28127311

RESUMO

Background. High no-show rates can burden clinic productivity and affect patient care. Although multiple studies have shown that text messages improve appointment adherence, very little research has focused on low-income and predominantly African American populations in resident clinic settings. Objectives. To determine whether incorporating a text message reminder reduces the no-show rate at an urban, pediatric resident clinic. Methods. A randomized controlled trial was conducted at a tertiary level ambulatory pediatric practice between August 2014 and February 2015. Following a demographic survey, 170 patients were enrolled. Patients were randomized into control or intervention groups. All patients received the standard voice message appointment reminder, but the intervention group additionally received a text message reminder. The primary outcome was no-show rate. Results. 95.3% of the participants were African American, and the overall no-show rate was 30.8%. No-show rate was significantly lower in the intervention group (23.5%) than the control group (38.1%) representing a difference of 14.6% (p = 0.04). No demographic factors were found to alter the association between no-show rate and text message intervention. Conclusions. Text message reminders effectively improve show rates at a resident pediatric practice with high no-show rates, representing a promising approach to improving appointment adherence.

12.
J Pediatr Adolesc Gynecol ; 28(1): 53-56, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25555301

RESUMO

STUDY OBJECTIVE: This study examined awareness among adolescents of a local rape crisis center as well as their knowledge about sexual violence. DESIGN: The Cleveland Rape Crisis Center (CRCC) conducts sexual violence prevention programs for high school students. A written, anonymous survey was distributed to students prior to the start of the program. Students were asked if they had heard of the CRCC; knowledge about sexual violence was assessed with a series of 7 statements (rape myths) that participants identified as true or false. Surveys were reviewed retrospectively. Analyses were carried out for individual questions and frequencies compared using chi-square analysis. RESULTS: A total of 1633 surveys were collected; 1118 (68.5%) participants were female and 514 (31.5%) were male; ages ranged from 12 to 19 years. Respondents described themselves as being of European descent (45.9%), African descent (26.2%), or mixed race (17.7%). Just over half (863, 52.9%) of survey respondents had heard of the CRCC. Over half (950, 58.2%) of participants answered 5 or more questions correctly (range of correct answers 0 to 7). In general, more participants who were aware of the CRCC were able to identify statements about rape correctly (P < .01 for statements 1, 4, 5, 6, and 7, P < .001 for ≥ 5 correct). Age, gender, and race were all significantly associated with knowledge about rape. Females were consistently more likely to get an answer correct, as were participants of European descent. CONCLUSION: Awareness of the CRCC was associated with increased knowledge about sexual violence.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Estupro/psicologia , Delitos Sexuais/psicologia , Estudantes/estatística & dados numéricos , Adolescente , Fatores Etários , Criança , Serviços de Saúde Comunitária/estatística & dados numéricos , Feminino , Humanos , Masculino , Ohio , Grupos Raciais , Instituições Acadêmicas , Fatores Sexuais , Estudantes/psicologia , Inquéritos e Questionários , Adulto Jovem
13.
Glob Pediatr Health ; 1: 2333794X14561656, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-27335923

RESUMO

Purpose. To describe the self-reported risky behaviors associated with adolescent social media use. Methods. Adolescents ages 13 to 21 years were recruited from a large, urban academic center to complete a written survey regarding social media use. Results are presented as frequencies and percentage; nominal variables were compared using χ(2) analysis. Results. Almost all participants (93%) reported belonging to a social media site. The majority of adolescents (72%) access the Internet with a phone. Nearly half (49%) of participants accept friend requests from strangers, 42% send friend requests to strangers, and 55% of participants report meeting people from social media sites in person. Conclusion. Adolescents self-report engaging in a number of risky behaviors when they use social media. Teenagers' use of social media is an additional behavior that requires attention and monitoring.

14.
Clin Pediatr (Phila) ; 52(4): 355-61, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23460647

RESUMO

BACKGROUND: The ability to diagnose eating disorders (ED) is important and difficult for primary care physicians (PCPs). Previous reports suggest that PCPs feel their training is inadequate. OBJECTIVE: To explore residents' interest and comfort diagnosing and treating ED. METHODS: An internet survey was sent to primary care residencies. Logistic regression models were fitted to identify factors correlated with residents' interest and comfort in diagnosing and treating ED. RESULTS: Family Medicine and Internal Medicine residents had higher interest in ED than Pediatric residents, as did female residents and residents exposed to teenagers with unexplained weight loss. Residents in programs with an ED program and faculty interested in ED were more comfortable diagnosing ED. CONCLUSIONS: Interest in, and comfort diagnosing and treating ED are associated with specialty type, presence of an ED program, presence of faculty interested in ED, and resident exposure to ED outpatients and teenagers with unexplained weight loss.


Assuntos
Atitude do Pessoal de Saúde , Competência Clínica , Medicina de Família e Comunidade/educação , Transtornos da Alimentação e da Ingestão de Alimentos , Medicina Interna/educação , Internato e Residência , Pediatria/educação , Transtornos da Alimentação e da Ingestão de Alimentos/diagnóstico , Transtornos da Alimentação e da Ingestão de Alimentos/terapia , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Modelos Logísticos , Masculino , Estados Unidos
16.
Fertil Steril ; 90(6): 2060-7, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18222431

RESUMO

OBJECTIVE: To determine whether bone mineral density (BMD) is lower in hormonal-contraceptive users than in an untreated comparison group. DESIGN: Observational, prospective cohort; 24-month duration. SETTING: Adolescent clinics in a metropolitan Midwestern setting. PATIENT(S): Four hundred thirty-three postmenarcheal girls, 12-18 years of age, who were on depot medroxyprogesterone acetate (DMPA; n = 58), were on oral contraceptives (OCs; n = 187), or were untreated (n = 188). INTERVENTION(S): Depot medroxyprogesterone acetate and OCs containing 100 microg of levonorgestrel and 20 microg of ethinyl E(2). MAIN OUTCOME MEASURE(S): Measurements of BMD at spine and femoral neck were obtained by using dual x-ray absorptiometry at baseline and 6-month intervals. RESULT(S): Over 24 months, mean percentage change in spine BMD was as follows: DMPA, -1.5%; OC, +4.2%; and untreated, +6.3%. Mean percentage change in femoral neck BMD was as follows: DMPA, -5.2%; OC, +3.0%; and untreated, +3.8%. Statistical significance was found between the DMPA group and the other two groups. In the DMPA group, mean percentage change in spine BMD over the first 12 months was -1.4%; the rate of change slowed to -0.1% over the second 12 months. No bone density loss reached the level of osteopenia. CONCLUSION(S): Adolescent girls receiving DMPA had significant loss in BMD, compared with bone gain in the OC and untreated group. However, the clinical significance of this finding is mitigated by slowed loss after the 1st year of DMPA use and general maintenance of bone density values within the normal range in the DMPA group.


Assuntos
Densidade Óssea/efeitos dos fármacos , Anticoncepcionais Femininos/administração & dosagem , Anticoncepcionais Orais Combinados/administração & dosagem , Anticoncepcionais Orais Hormonais/administração & dosagem , Etinilestradiol/administração & dosagem , Levanogestrel/administração & dosagem , Acetato de Medroxiprogesterona/administração & dosagem , Absorciometria de Fóton , Adolescente , Criança , Anticoncepcionais Femininos/efeitos adversos , Anticoncepcionais Orais Combinados/efeitos adversos , Anticoncepcionais Orais Hormonais/efeitos adversos , Preparações de Ação Retardada , Etinilestradiol/efeitos adversos , Feminino , Colo do Fêmur/diagnóstico por imagem , Colo do Fêmur/efeitos dos fármacos , Humanos , Injeções Intramusculares , Levanogestrel/efeitos adversos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/efeitos dos fármacos , Acetato de Medroxiprogesterona/efeitos adversos , Meio-Oeste dos Estados Unidos , Estudos Prospectivos , Fatores de Tempo
17.
J Adolesc Health ; 39(2): 261-5, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16857539

RESUMO

PURPOSE: To identify adolescents' and parents' understanding of confidentiality in the patient/doctor relationship. METHODS: In the teen clinic of an academic hospital, questionnaires were administered separately to 50 accompanying parents and 50 adolescents aged 13 to 17 years. The true/false questions were designed to identify both adolescents' and parents' perceptions of the general breadth and limitations of confidentiality and specifically related to selected high-risk behaviors. RESULTS: Most adolescents and parents understood confidentiality to mean that conversations, testing and treatments about certain aspects of health care could be kept private between a doctor and patient. However, most parents felt that confidentiality guidelines did not apply to patients under 18 years. In contrast to 36% of adolescents, 96% of parents believe that the doctor would discuss any conversation the doctor had with the patient that might be important to the parent in spite of adolescents' wish for them not to be told. Parent/adolescent dyads agreed regarding the general value of a confidential adolescent/doctor relationship and the application of confidentiality to certain topics but disagreed with respect to others. CONCLUSIONS: The adolescents and parents in this study have a good understanding of the meaning of confidentiality but are less clear on its application to the adolescent patient/doctor relationship. Nearly all adolescents and their parents appreciate the circumstances under which confidentiality will be breached. The protections confidentiality offers adolescents are understood less well by both parties, but parents seem to have a greater degree of misunderstanding. Parents believe that the doctor will inform them about many of their adolescents' high-risk behaviors. These false impressions may lead to assumptions, miscommunication, and conflict in the adolescent patient/doctor/parent triad.


Assuntos
Negro ou Afro-Americano/psicologia , Confidencialidade , Relações Pais-Filho , Relações Médico-Paciente/ética , Adolescente , Adulto , Feminino , Política de Saúde , Inquéritos Epidemiológicos , Humanos , Conhecimento , Masculino
18.
Am J Obstet Gynecol ; 192(1): 42-7, 2005 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-15672001

RESUMO

OBJECTIVE: The purpose of this clinical trial was to evaluate the effect of estrogen supplementation on bone mineral density in adolescent girls who received depot medroxyprogesterone acetate for contraception. STUDY DESIGN: One hundred twenty-three adolescents who began receiving depot medroxyprogesterone acetate injections every 12 weeks were assigned randomly to receive monthly injections of estradiol cypionate or placebo. The main outcome was bone mineral density that was measured by dual energy x-ray absorptiometry for 12 (n = 69) to 24 (n = 36) months. Participants, technicians, and physicians were blinded to estrogen treatment. RESULTS: Over the 24-month period, the percentage of change from baseline bone mineral density at the lumbar spine was 2.8% in the estradiol cypionate group versus -1.8% in the placebo group ( P <.001). At the femoral neck, the percentage of change from baseline bone mineral density was 4.7% in the estradiol cypionate group versus -5.1% in the placebo group ( P <.001). CONCLUSION: Our results suggest that estrogen supplementation is protective of bone in adolescent girls who receive depot medroxyprogesterone acetate injections.


Assuntos
Densidade Óssea/efeitos dos fármacos , Anticoncepcionais Femininos , Estradiol/farmacologia , Acetato de Medroxiprogesterona , Absorciometria de Fóton , Adolescente , Método Duplo-Cego , Estradiol/administração & dosagem , Feminino , Fêmur , Humanos , Injeções Intramusculares , Vértebras Lombares , Resultado do Tratamento
19.
J Adolesc Health ; 35(6): 434-41, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15581522

RESUMO

PURPOSE: To conduct a longitudinal comparison of bone mineral density (BMD) in 370 adolescent girls, aged 12-18, who self-selected depot medroxyprogesterone acetate (DMPA) or an oral contraceptive (OC) containing 20 microg ethinyl estradiol/100 microg levonorgestrel with that in girls who received no hormonal treatment (control group). METHODS: Lumbar spine and femoral neck BMD measurements were obtained by dual energy x-ray absorptiometry at baseline and 12 months. Data were analyzed with repeated measures analysis of covariance methods. RESULTS: Over 12 months, lumbar spine BMD decreased in the DMPA group (n = 29), with a mean percent change of -1.4% (95% confidence interval [CI] -2.73, -0.10), and increased by a mean of 3.8% (95% CI 3.11, 4.57) in the control group [n = 107 (p < .001)]. The increase in mean percent change in lumbar spine BMD in the OC group (n = 79), 2.3% (95% CI 1.49, 3.18), was significantly smaller than in the control group (p = .03). Over 12 months, the mean percent change in femoral neck BMD was -2.2% (95% CI -3.95, -0.39) in the DMPA group, but increased 2.3% (95% CI 1.29, 3.27) in the control group (p < .001). The increase in mean percent change at the femoral neck in the OC group, 0.3% (95% CI -0.87, 1.41), was significantly lower than in the control group (p = .03). CONCLUSIONS: Our study contributes to an increasing body of knowledge indicating a negative impact of DMPA on bone health in young women. Additional findings suggest a potential adverse effect of an OC containing 20 microg ethinyl estradiol/100 microg levonorgestrel on bone health in adolescents.


Assuntos
Desmineralização Patológica Óssea/induzido quimicamente , Densidade Óssea/efeitos dos fármacos , Anticoncepcionais Femininos/efeitos adversos , Etinilestradiol/efeitos adversos , Levanogestrel/efeitos adversos , Acetato de Medroxiprogesterona/efeitos adversos , Absorciometria de Fóton , Adolescente , Serviços de Saúde do Adolescente/normas , Índice de Massa Corporal , Desmineralização Patológica Óssea/diagnóstico por imagem , Desmineralização Patológica Óssea/epidemiologia , Desmineralização Patológica Óssea/prevenção & controle , Desenvolvimento Ósseo/efeitos dos fármacos , Estudos de Coortes , Intervalos de Confiança , Anticoncepcionais Femininos/administração & dosagem , Anticoncepcionais Orais Hormonais/efeitos adversos , Anticoncepcionais Orais Sintéticos/efeitos adversos , Preparações de Ação Retardada/efeitos adversos , Etinilestradiol/administração & dosagem , Feminino , Colo do Fêmur/metabolismo , Educação em Saúde , Humanos , Levanogestrel/administração & dosagem , Vértebras Lombares/metabolismo , Acetato de Medroxiprogesterona/administração & dosagem , Razão de Chances , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo , Estados Unidos/epidemiologia
20.
J Pediatr Adolesc Gynecol ; 17(6): 373-7, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15603978

RESUMO

STUDY OBJECTIVE: To examine the relationship between biochemical markers of bone metabolism and hormonal contraception in adolescents. DESIGN: A prospective, observational design. SETTING: The study was conducted in four adolescent health clinics in a large metropolitan area. PARTICIPANTS: The study population comprised healthy, postmenarcheal adolescent girls aged 12-18 initiating either medroxyprogesterone acetate (n=53) or an oral contraceptive (OC) containing 20 mug ethinyl estradiol/100 mug levonorgestrel (n=165) and those using no hormonal contraception (n=152). INTERVENTIONS: None. MAIN OUTCOME MEASURES: Serum bone specific alkaline phosphatase (BSAP), urinary deoxypyridinoline (DPD), and bone mineral density (BMD) at baseline and 12 months. RESULTS: At 12 month follow-up, serum BSAP levels were significantly higher (P < 0.05) in the control group (40.4 U/L +/- 1.03 SE), than in the DMPA group (35.2 U/L +/- 1.05 SE) and the OC group (35.5 U/L +/- 1.03 SE). There was a trend in urinary DPD levels to be higher (P=0.08) in the control group (9.9 nmol/mmol Cr +/- 1.03 SE) than in the DMPA group (9.1 +/- 1.05 SE) and the OC group (8.9 +/- 1.03 SE). No relationship was found between the biochemical markers and BMD at the lumbar spine or the femoral neck. CONCLUSIONS: Over 12 months, there was evidence of increased bone formation and resorption in the control group when compared to that in the DMPA and OC groups. This finding may indicate a suppression of bone metabolism in girls using DMPA or an OC containing 20 mug ethinyl estradiol/100 mug levonorgestrel.


Assuntos
Biomarcadores/metabolismo , Osso e Ossos/metabolismo , Anticoncepcionais Orais , Acetato de Medroxiprogesterona , Adolescente , Fosfatase Alcalina/sangue , Aminoácidos/urina , Densidade Óssea , Reabsorção Óssea , Estudos de Casos e Controles , Etinilestradiol , Feminino , Seguimentos , Humanos , Levanogestrel , Estudos Prospectivos , Fatores de Tempo
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