RESUMO
Breast cancer is a heterogeneous disease with different tumor subtypes. Identifying risk categories will help make better treatment decisions. Hence, this study aimed to predict the survival outcomes of invasive breast cancer in Vietnam, using St Gallen 2007 classification. This study was conducted on 501 patients with breast cancer who had surgical operations, but had not received neoadjuvant chemotherapy, from 2011 to 2013. The clinicopathological characteristics were recorded. Immunohistochemistry staining was performed on ER, PR, HER2/neu, and Ki67 markers. For HER2/neu(2+), fluorescence in situ hybridization was used as the test. All patients with breast cancer were stratified according to 2007 St Gallen categories. Kaplan-Meier and log-rank models were used to analyze survival rates. There were 3.8% cases classified as low risk (LR), 72.1% as intermediate risk (IR1: 60.1% and IR2: 12.0%), and 24.1% as high risk (HR1: 11.8% and HR2: 12.3%). Patients who were LR had the best prognosis, with a 5-year overall survival (OS) rate of 100%. Intermediate-risk patients were at 92.3%. High-risk patients had the worst prognosis, with a 5-year OS proportion of 69.3% (P < .05). For disease-free survival (DFS), risk categories were categorized as LR: 100%, IR: 90.3%, and HR: 69.3% (P < .05). Three main risk categories of breast cancer had a distinct OS and DFS. These findings suggest that the 2007 St Gallen risk category could be used to stratify patients with breast cancer into different risk groups in Vietnam.
Assuntos
Biomarcadores Tumorais/análise , Neoplasias da Mama/mortalidade , Adulto , Idoso , Biomarcadores Tumorais/metabolismo , Mama/patologia , Mama/cirurgia , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Intervalo Livre de Doença , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Mastectomia , Pessoa de Meia-Idade , Prognóstico , Medição de Risco/métodos , Fatores de Risco , Taxa de Sobrevida , Vietnã/epidemiologiaRESUMO
418 patients with stomach cancer (296 males, 162 females, aged 58.3 13.6) treated by endoscopic biopsy at Hospital K in Hanoi from 2001 to 2003. The most common patients group was 61-70 age group, then 51-60 age group, > 70 age group, 41-50 age group and the less was < 41 age group. The disease was more common on male than female. Cancer on the pylore accounted for ½ of all cases and cancer occurred in other locations with less frequency. Histologicaly, carcinoma occurred the highest rate 97.6%. Lymphomas, gastro-intestinal stromal tumors and neuromas, and endocrino-neuromas had got less rate.
