RESUMO
The aim of the present study was to evaluate the role of the C-514T (rs1800588) gene polymorphism of the hepatic lipase (LIPC) as susceptibility marker for fatty liver in the Mexican population. The polymorphism was genotyped by 5' exonuclease TaqMan assays in a group of 1468 subjects (980 with and 488 without fatty liver) belonging to the Genetics of Atherosclerotic Disease (GEA) Mexican Study. Anthropometric and biochemical measurements were performed on all individuals. The polymorphism was not associated with fatty liver, however, under dominant model, the TT genotype was associated with increased levels of triglycerides (P=0.0002), apolipoprotein A1 (P=0.015), triglycerides/HDL-cholesterol index (P=0.046) and increased frequency of type 2 diabetes mellitus (P=0.045). On the other hand, the same genotype was associated with the presence of small LDLs (P=0.003). The risk analysis showed that under a dominant model, the LIPC C-514T polymorphism was associated with increased risk of type 2 diabetes (OR=1.42, P=0.029), hypertriglyceridemia (OR=1.36, P=0.006), and coronary artery calcification (CAC)≥1 (OR=1.44, P=0.015) and decreased risk of hypoalphalipoproteinemia (OR=0.78, P=0.036). The results suggest that the LIPC C-154T polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver in Mexican population. The association detected with CAC indicates that this polymorphism could be a marker for subclinical atherosclerosis.
Assuntos
Biomarcadores/metabolismo , Doenças Cardiovasculares/genética , Diabetes Mellitus Tipo 2/genética , Fígado Gorduroso/genética , Lipase/genética , Polimorfismo Genético/genética , Adulto , Idoso , Apolipoproteína A-I/metabolismo , Doenças Cardiovasculares/metabolismo , Doenças Cardiovasculares/patologia , Estudos de Casos e Controles , Colesterol/metabolismo , HDL-Colesterol/metabolismo , Diabetes Mellitus Tipo 2/metabolismo , Diabetes Mellitus Tipo 2/patologia , Fígado Gorduroso/metabolismo , Fígado Gorduroso/patologia , Feminino , Seguimentos , Humanos , Lipoproteínas HDL/metabolismo , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Prognóstico , Fatores de Risco , Triglicerídeos/metabolismoRESUMO
The present work describes the prevalence of cardiovascular risk factors in young mexican women. 96 women from 18 to 40 years of age were included. All of them were measured (height, waist and hip) and weighed, blood pressure was registered, laboratory exams were taken and a questionnaire was answered. Cardiovascular risk factors prevalence was estimated and the average concentrations of lipids and glucose and systolic and diastolic blood pressure were compared by age, BMI and WHI group. Of the studied women, 51% were overweight or obese and 51% had visceral obesity with a high prevalence of lipids abnormalities (hypoalpha-lipoproteinemia and hypertrigliceridemia), which increases progressively with age. Only 5% and 4% had normal to high systolic and dyastolic blood pressures and 7% had blood glucose > 110 mg/dL. In this sample of women with similar social, demographic, economic, and cultural characteristics, a high proportion was identified with body weight problems and lipids abnormalities, a frequent finding in Latin populations with multiple etiologies and associated with different cardiovascular risk factors.
Assuntos
Adolescente , Adulto , Feminino , Humanos , Doenças Cardiovasculares , Fatores Etários , Glicemia , Doenças Cardiovasculares , Colesterol/sangue , Interpretação Estatística de Dados , Dislipidemias , Hipertensão , México , Obesidade , Prevalência , Fatores de Risco , Fatores Sexuais , Fatores Socioeconômicos , Triglicerídeos/sangueRESUMO
The present work describes the prevalence of cardiovascular risk factors in young mexican women. 96 women from 18 to 40 years of age were included. All of them were measured (height, waist and hip) and weighed, blood pressure was registered, laboratory exams were taken and a questionnaire was answered. Cardiovascular risk factors prevalence was estimated and the average concentrations of lipids and glucose and systolic and diastolic blood pressure were compared by age, BMI and WHI group. Of the studied women, 51% were overweight or obese and 51% had visceral obesity with a high prevalence of lipids abnormalities (hypoalpha-lipoproteinemia and hypertrigliceridemia), which increases progressively with age. Only 5% and 4% had normal to high systolic and dyastolic blood pressures and 7% had blood glucose > 110 mg/dL. In this sample of women with similar social, demographic, economic, and cultural characteristics, a high proportion was identified with body weight problems and lipids abnormalities, a frequent finding in Latin populations with multiple etiologies and associated with different cardiovascular risk factors.
