RESUMO
In experimental trials on cattle, ivermectin given SC at 200 micrograms/kg had 95% or better efficacy against adult and immature GI and pulmonary nematodes, including inhibited fourth-stage larvae of Ostertagia ostertagi. Studies of efficacy against ectoparasites revealed nearly 100% efficacy against sucking lice, psoroptic and sarcoptic mange mites and cattle grubs. Safety trials revealed no adverse effects with the recommended dosage, including bulls and pregnant cows. A few grub-infested cattle died from acute esophagitis associated with a host-parasite reaction after ivermectin injection.
Assuntos
Doenças dos Bovinos/tratamento farmacológico , Ectoparasitoses/veterinária , Lactonas/uso terapêutico , Infecções por Nematoides/veterinária , Animais , Anoplura/isolamento & purificação , Anti-Helmínticos/uso terapêutico , Bovinos , Dípteros/isolamento & purificação , Ectoparasitoses/tratamento farmacológico , Feminino , Inseticidas/uso terapêutico , Ivermectina , Ácaros/isolamento & purificação , Infecções por Nematoides/tratamento farmacológico , GravidezAssuntos
Legislação de Medicamentos , Legislação sobre Alimentos , Legislação Veterinária , United States Food and Drug Administration , Ração Animal/normas , Animais , Antibacterianos/uso terapêutico , Custos e Análise de Custo , Avaliação Pré-Clínica de Medicamentos/veterinária , Aditivos Alimentares , Alimentos Fortificados , Toxicologia , Estados UnidosRESUMO
The effect of arpinocid (9-[2-chloro-6-fluorophenyl)methyl]-9H-purin-6-amine) on artificial and natural coccidial infections in broiler chickens was evaluated in a series of pen trials conducted in England, France, and Germany. In trials with induced infections, mortality attributable to coccidiosis did not occur at 50, 60, and 70 ppm although it ranged from 3.2 to 9% in unmedicated groups. At 7 to 8 weeks of age, birds receiving arprinocoid in feed at levels of 40, 50, 60, and 70 ppm had improved body weights and feed conversion compared with unmedicated birds, the differences being significant (P is less than .05) in 4 out of 5 trials. Productivity of birds on arprinocid was equivalent or significantly superior (P is less than 0.5) to those on halofuginone (3 ppm), monensin (100 ppm), nicarbazin (125 ppm), and PANCOXIN (165 ppm). Based on the results of these pen trials, arprinocid at levels of 50 to 70 ppm in feed is a highly efficacious compound for the prophylaxis of coccidiosis, preventing mortality, and permitting good growth and feed conversion under conditions of both mild and severe infection pressure.
Assuntos
Adenina/análogos & derivados , Galinhas , Coccidiose/veterinária , Coccidiostáticos/uso terapêutico , Doenças das Aves Domésticas/prevenção & controle , Adenina/uso terapêutico , Ração Animal , Animais , Compostos de Benzil/uso terapêutico , Peso Corporal , Coccidiose/prevenção & controle , Inglaterra , França , Alemanha Ocidental , Aves DomésticasRESUMO
Eight floor pen trials were conducted to determine the effect of arprinocid on the weight, feed efficiency, and histological lesions of broiler chickens exposed to coccidiosis. In three trials, the levels of arprinocid were 0, 40, 60, 70, 80, and 90 ppm, and in the other five trials, 0, 50, 75, and 100 ppm. Histological lesions were significantly (P less than .05) reduced in the medicated birds. Weights were not significantly (P less than .05) different between birds given 40, 60, or 70 ppm in the first series of trials no 50 and 75 ppm drug in the second and third series, although in both series the treated birds were significantly (P less than .05) heavier than the control birds. Feed efficiency was improved by all levels of arprinocid in the first and third series of trials and by 75 ppm in the second series.
