[An epidemiological assessment of the chronic carriage of the hepatitis B virus surface antigen and other markers of this infection]. / Epidemiologicheskaia otsenka khronicheskogo nositel'stva poverkhnostnogo antigena virusa gepatita B i drugikh markerov étoi infektsii.

On the basis of prolonged (up to 10 years) observations of chronic HBsAg carriers (87 persons) slowly progressing chronic hepatitis B virus infection was detected in most of them (57.5%). In these persons up to 6 negative results of the analysis for the presence of HBsAg were periodically obtained, with the subsequent renewal of HBs-antigenemia. More profound examination of 192 persons with chronic lesions of the liver and other digestive organs helped diagnose chronic persistent hepatitis and chronic active hepatitis, accompanied by HBs-antigenemia and the circulation of other markers of this infection, in 63.5% of the examinees.

[Effect of endolymphatic antibiotic therapy on the status of cellular immunity in peritonitis]. / Vliianie éndolimfaticheskoi antibiotikoterapii na sostoianie kletochnogo immuniteta pri peritonite.

The immune status in 68 patients with diffuse and generalized peritonitis was studied. It was established, that a degree of the impairment in immune response depended on peritonitis spreading. Endolymphatic antibiotic therapy had immunostimulating effect in patients with diffuse peritonitis, in generalized peritonitis, this was not observed. In patients with generalized peritonitis, it is necessary to include into the complex of treatment the other methods of immunologic correction.

[Use of automatic blood analyzer, Hemalog D, in cancer patients during radiotherapy and chemotherapy]. / Primenenie avtomaticheskogo analizatora krovi "gemalog D" u onkologicheskikh bol'nykh v protsesse luchevoi i khimioterapii.

The Hemalog D automatic cytochemical analyser was used to assess changes in the levels of neutrophil peroxidase and monocyte non-specific esterase in 194 cancer patients undergoing radiation and chemotherapy. Radiotherapy in the dose of 30-48 Gy did not affect functional activity of blood leukocytes. Combination chemotherapy induced moderate or severe leukopenia in 72.7% of cases. A decrease in the enzymatic activity of neutrophils and monocytes was observed in patients with normal and slightly decreased leukocyte counts. In patients with severe leukopenia, elevated levels of peroxidase and non-specific esterase in leukocytes were found.

[Cellular immunity in peritonitis caused by appendicitis and peptic ulcer perforation]. / Sostoianie kletochnogo immuniteta pri peritonite, obuslovlennom appenditsitom i perforatsiei iazvy.

In examination of 26 patients with peritonitis caused by appendicitis and ulcer perforation, the suppression of T-cellular immunity, which grew with the progression of a pathological process, was established. In perforative peritonitis, the more rapid and deep, as compared with appendicular peritonitis, suppression of the T-system of the immunity was noted.

[Late results of treating cervical cancer with a proton beam]. / Otdalennye rezul'taty lecheniia raka sheiki matki puchkom protonov.

The authors described methods of cervical cancer therapy performed in 1970 using the proton beam of the Institute of Theoretical and Experimental Physics and analyzed long-term results. The use of protons resulted in homogeneous irradiation of a preset target volume without injuring the adjacent organs and tissues. Proton beam irradiation of the uterus was combined with gamma-beam therapy of the zones of regional metastatic spreading. Postradiation reactions were unobserved in the adjacent bladder and rectum in patients receiving combined therapy and irradiation alone. The clinical efficacy of proton beam irradiation was confirmed by the treatment of 160 patients.

[Methodological bases for the study and the patterns of the seasonality of viral hepatitis A]. / Metodicheskie osnovy izucheniia i zakonomernosti sezonnosti virusnogo gepatita A.

On the basis of the study of the data on the incidence of viral hepatitis A in one of the districts of a big city for 20 years the authors come to the conclusion on the advisability of a comparative study of the monthly changes in the incidence of hepatitis A within individual uniform morbidity cycles covering the periods of many years and the use of average monthly data for many years for plotting the typical curve, as well as the use of the simplified for the calculation of the upper limit of annual morbidity. Similarities and differences in the monthly dynamics of morbidity in the years of high and low morbidity levels have been revealed, and the age group of the population (20-39 years) which ensures the continuity of the epidemic process all the year round has been determined. The factors contributing to the seasonal activation of the epidemic process start operating in June among schoolchildren aged 11-14 years, and later their operation spreads to other groups of the population.

[Prospects for using the Institute of Theoretical and Experimental Physics proton beam for treating gynecologic cancer patients]. / Vozmozhnosti ispol'zovaniia protonnogo puchka ITEF dlia lecheniia onkoginekologicheskikh bol'nykh.

Untoward side-effects of exposure of normal tissues surrounding tumor in the course of radiation treatment were avoided due to the use of a proton beam developed at the Institute of Theoretical and Experimental Physics. As a result, no post-treatment complications were observed in the surrounding tissues of the urinary bladder and rectum in 175 cancer patients (tumors of the vulva-39 and cervix uteri-136) who received a course of complex radiation treatment and preoperative irradiation.