[Use of infusion solution remaxol in the combination treatment of patients with leptospirosis].

AIM: To evaluate the efficiency of using remaxol in the combination treatment of patients with leptospirosis. SUBJECTS AND METHODS: Thirty patients (29 men and 1 woman) with leptospirosis were treated with remaxol. The icteric and anicteric forms of the disease were diagnosed in 28 and 2 patients, respectively. Moderate, severe, and very severe leptospirosis were observed in 3, 24, and 3 cases, respectively. Remaxol was injected intravenously as a ready-to-use infusion solution 400 ml/day; the treatment duration was 3 to 9 days at the height of the disease. RESULTS: Clinical improvement and normalization of laboratory parameters were achieved in the course of the disease. There were no deaths. During early convalescence at 4-5 weeks of the disease, the patients taking remaxol at the height of the disease were substantially more rarely recorded to have general weakness, fever, anorexia, myalgia, leukocytosis, increased erythrocyte sedimentation rate, and hyperbilirubinemia than those untreated with this drug. CONCLUSION: The performed study established the clinical efficacy of remaxol when used in the combination treatment of patients with leptospirosis.

[Characteristic of HIV-infection epidemic process in Krasnodar region].

AIM: To assess the incidence of HIV-infection in Krasnodar region in long-term period. MATERIALS AND METHODS: Log books for notifications on infectious diseases, medical records and abstracts from epidemiologic investigations files were analyzed. Statistical analysis of incidence figures with computation of mean values, their errors as well as correlation coefficients was performed by standard methods. RESULTS: During 1996-2000 the incidence varied from 6.7 to 15.0 per 100,000 with mean value 11.6 +/- 0.6. Extensive and intensive indexes of HIV-infection according to sex, age, place of residence (urban or rural territory) and social status were calculated, causes of infection during mentioned years were studied. Increase of HIV-infection incidence in women and rural population as well as in older groups (decrease of disease incidence in people under 25 years of age and increase in people over 40 years of age) was noted. During last years sexual transmission route of infection predominates over parenteral during use of narcotic drugs. CONCLUSION: Characteristic of HIV-infection epidemic process in Krasnodar region was done, which points to its evolutionary transformation during last years.