[The results of the clinical use of the immobilized-protease enzyme profezim in treating exacerbated chronic periodontitis]. / Rezul'taty klinicheskogo primeneniia fermenta immobilizovannykh proteaz profezima v lechenii khronicheskogo periodontita v stadii obostreniia.

The authors characterize the action of profezyme, an immobilized proteinase enzyme, used in the treatment of patients with exacerbations of chronic periodontitis. Time course of symptomatology was followed up in 65 patients in various periods of periodontitis therapy. Prolonged enzymic therapy helped reduce the length of treatment by 2-3 times.

[Effect of electrostimulation of the dorsolateral funiculus of the spinal cord on changes in the cardiac rhythm in acute myocardial ischemia]. / Vliianie élektrostimuliatsii dorsolateral'nogo kanatika spinnogo mozga na izmeneniia ritma serdtsa pri ostroi ishemii miokarda.

The experiments were carried out on inbred white male rats. Cardiac rhythm changes revealed in acute myocardial ischemia under conditions of electrostimulation (ES) of descending sympathicoinhibitory pathways, constituting part of spinal dorsolateral funiculi (DLF) were studied. 10-min stimulation of DLF, started immediately after ligation of the left coronary artery, checked the development of severe cardiac arrhythmia, or considerably weakened the already existing one. The data obtained substantiate the assumption that the onset of cardiac arrhythmia in acute ischemia is associated with the involvement of sympathic preganglionic neurons into the pathologic system, which may be suppressed by the activation of the functionally opposite systems.

[Characteristics of the rhythmic activity of a normal and a damaged heart during hyperactivity of spinal cord preganglionic neurons]. / Kharakter ritmicheskoi deiatel'nosti zdorovogo i povrezhdennogo serdtsa pri giperaktivnosti preganglionarnykh neironov spinnogo mozga.

Experiments on white rats were made to investigate the character of rhythmical activity of normal heart and that in acute myocardial ischemia in response to electrical stimulation of preganglionic neurons (PN) of the thoracic part of the spinal cord and the formation in them of the generator of pathologically enhanced excitation induced by microinjection of tetanus toxin. In both types of PN hyperactivation, arrhythmias of different patterns developed, their severity and duration being related to the level of initial cardiac reactivity and the degree of PN excitation. It is suggested that under distress of the autonomous mechanisms responsible for regulation of the injured heart, hyperactivation of the spinal cord sympathetic apparatus might be a factor provoking arrhythmia.