Motion compensation for aortic valves using partial angle CT reconstructions.

PURPOSE: A motion compensation method that is aimed at correcting motion artifacts of cardiac valves is proposed. The primary focus is the aortic valve. METHODS: The method is based around partial angle reconstructions and a cost function including the image entropy. A motion model is applied to approximate the cardiac motion in the temporal and spatial domain. Based on characteristic values for velocities and strain during cardiac motion, penalties for the velocity and spatial derivatives are introduced to maintain anatomically realistic motion vector fields and avoid distortions. The model addresses global elastic deformation, but not the finer and more complicated motion of the valve leaflets. RESULTS: The method is verified based on clinical data. Image quality was improved for most artifact-impaired reconstructions. An image quality study with Likert scoring of the motion artifact severity on a scale from 1 (highest image quality) to 5 (lowest image quality/extreme artifact presence) was performed. The biggest improvements after applying motion compensation were achieved for strongly artifact-impaired initial images scoring 4 and 5, resulting in an average change of the scores by - 0.59 ± 0.06 $-0.59\pm 0.06$ and - 1.33 ± 0.03 $-1.33\pm 0.03$ , respectively. In the case of artifact-free images, a chance to introduce blurring was observed and their average score was raised by 0.42 ± 0.03. CONCLUSION: Motion artifacts were consistently removed and image quality improved.

Deep learning-based coronary artery motion estimation and compensation for short-scan cardiac CT.

PURPOSE: During a typical cardiac short scan, the heart can move several millimeters. As a result, the corresponding CT reconstructions may be corrupted by motion artifacts. Especially the assessment of small structures, such as the coronary arteries, is potentially impaired by the presence of these artifacts. In order to estimate and compensate for coronary artery motion, this manuscript proposes the deep partial angle-based motion compensation (Deep PAMoCo). METHODS: The basic principle of the Deep PAMoCo relies on the concept of partial angle reconstructions (PARs), that is, it divides the short scan data into several consecutive angular segments and reconstructs them separately. Subsequently, the PARs are deformed according to a motion vector field (MVF) such that they represent the same motion state and summed up to obtain the final motion-compensated reconstruction. However, in contrast to prior work that is based on the same principle, the Deep PAMoCo estimates and applies the MVF via a deep neural network to increase the computational performance as well as the quality of the motion compensated reconstructions. RESULTS: Using simulated data, it could be demonstrated that the Deep PAMoCo is able to remove almost all motion artifacts independent of the contrast, the radius and the motion amplitude of the coronary artery. In any case, the average error of the CT values along the coronary artery is about 25 HU while errors of up to 300 HU can be observed if no correction is applied. Similar results were obtained for clinical cardiac CT scans where the Deep PAMoCo clearly outperforms state-of-the-art coronary artery motion compensation approaches in terms of processing time as well as accuracy. CONCLUSIONS: The Deep PAMoCo provides an efficient approach to increase the diagnostic value of cardiac CT scans even if they are highly corrupted by motion.

Stack transition artifact removal (STAR) for cardiac CT.

INTRODUCTION: In cardiac computed tomography (CT), irregular motion may lead to unique artifacts for scanners with a longitudinal collimation that does not cover the entire heart. Given partial coverage, subvolumes, or stacks, may be reconstructed and used to assemble a final CT volume. Irregular motion, for example, due to cardiac arrhythmia or breathing, may cause mismatch between neighboring stacks and therefore discontinuities within the final CT volume. The aim of this work is the removal of the discontinuities that are hereafter referred to as stack transition artifacts. METHOD AND MATERIALS: A stack transition artifact removal (STAR) is achieved using a symmetric deformable image registration. A symmetric Demons algorithm was implemented and applied to stacks to remove mismatch and therefore the stack transition artifacts. The registration can be controlled with one parameter that affects the smoothness of the deformation vector field (DVF). The latter is crucial for realistically transforming the stacks. Different smoothness settings as well as an entirely automatic parameter selection that considers the required deformation magnitude for each registration were tested with patient data. Thirteen datasets were evaluated. Simulations were performed on two additional datasets. RESULTS AND CONCLUSION: STAR considerably improved image quality while computing realistic DVFs. Discontinuities, for example, appearing as breaks or cuts in coronary arteries or cardiac valves, were removed or considerably reduced. A constant smoothing parameter that ensured satisfactory results for all datasets was found. The automatic parameter selection was able to find a proper setting for each individual dataset. Consequently, no over regularization of the DVF occurred that would unnecessarily limit the registration accuracy for cases with small deformations. The automatic parameter selection yielded the best overall results and provided a registration method for cardiac data that does not require user input.

Optimization of the alpha image reconstruction - an iterative CT-image reconstruction with well-defined image quality metrics.

PURPOSE: Optimization of the AIR-algorithm for improved convergence and performance. METHODS: The AIR method is an iterative algorithm for CT image reconstruction. As a result of its linearity with respect to the basis images, the AIR algorithm possesses well defined, regular image quality metrics, e.g. point spread function (PSF) or modulation transfer function (MTF), unlike other iterative reconstruction algorithms. The AIR algorithm computes weighting images α to blend between a set of basis images that preferably have mutually exclusive properties, e.g. high spatial resolution or low noise. The optimized algorithm uses an approach that alternates between the optimization of rawdata fidelity using an OSSART like update and regularization using gradient descent, as opposed to the initially proposed AIR using a straightforward gradient descent implementation. A regularization strength for a given task is chosen by formulating a requirement for the noise reduction and checking whether it is fulfilled for different regularization strengths, while monitoring the spatial resolution using the voxel-wise defined modulation transfer function for the AIR image. RESULTS: The optimized algorithm computes similar images in a shorter time compared to the initial gradient descent implementation of AIR. The result can be influenced by multiple parameters that can be narrowed down to a relatively simple framework to compute high quality images. The AIR images, for instance, can have at least a 50% lower noise level compared to the sharpest basis image, while the spatial resolution is mostly maintained. CONCLUSIONS: The optimization improves performance by a factor of 6, while maintaining image quality. Furthermore, it was demonstrated that the spatial resolution for AIR can be determined using regular image quality metrics, given smooth weighting images. This is not possible for other iterative reconstructions as a result of their non linearity. A simple set of parameters for the algorithm is discussed that provides the mentioned results.