RESUMO
Studies on rats with experimental diabetes induced by administration of alloxan showed that transcranial electrostimulation of endorphinergic brain structures stimulates the regeneration of damaged beta-cells in pancreatic islets of Langerhans. This was identified on pancreatic sections stained with hematoxylin and eosin. De novo formation of small islets was noted, as evidenced by their regeneration from progenitor cells. After transcranial electrostimulation, islet beta-cells stained by the Gomori method showed recovery of granularity - a sign of insulin production. Application of an immunoenzyme method demonstrated recovery of blood insulin levels, the dynamics of increases in which showed a highly significant negative correlation with a decrease in blood glucose. These data led to the conclusion that the antihyperglycemic effect of transcranial electrostimulation in experimental alloxan diabetes results from reparative regeneration of beta-cells in islets of Langerhans with recovery of their insulin-producing function.
Assuntos
Diabetes Mellitus Experimental/patologia , Diabetes Mellitus Experimental/terapia , Células Secretoras de Insulina/metabolismo , Insulina/sangue , Regeneração Nervosa/efeitos dos fármacos , Estimulação Magnética Transcraniana , Animais , Glicemia/metabolismo , Modelos Animais de Doenças , Masculino , Regeneração Nervosa/fisiologia , Ratos , Ratos WistarRESUMO
In alloxan-induced diabetic rats, it was demonstrated that transcranial electrical stimulation of the brain endorphinergic structures activated the reparative regeneration of the damaged beta-cells of the Langerhans pancreatic islets. This was estimated on the histological sections of pancreas with hematoxylin-eosin staining. Several small newborn islets were found to originate from pancreatic progenitor cells. After transcranial electrical stimulation of insulin granules, beta-cells (Gomori's staining) were observed as an indication of the restoration of the insulin production. Correspondingly the increase of the blood insulin level was estimated by immune-enzyme method. The dynamics of the plasma insulin increase had a significant negative correlation with decrease of the blood glucose level. The glucose-lowering action of the transcranial electrical stimulation in alloxan-induced diabetic rats seems to be based on stimulation of the regeneration of damaged beta-cells with the restoration of their insulin production.
Assuntos
Diabetes Mellitus Experimental/fisiopatologia , Células Secretoras de Insulina/fisiologia , Insulina/sangue , Regeneração , Aloxano , Animais , Glicemia/análise , Córtex Cerebral , Estimulação Elétrica , Masculino , Ratos , Ratos WistarAssuntos
Glicemia/efeitos da radiação , Estimulação Encefálica Profunda/métodos , Diabetes Mellitus Experimental/terapia , Aloxano , Animais , Glicemia/análise , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/induzido quimicamente , Modelos Animais de Doenças , Masculino , Ratos , Ratos WistarAssuntos
Encéfalo/imunologia , Encéfalo/fisiopatologia , Eletronarcose/métodos , Hemodinâmica/efeitos dos fármacos , Neoplasias Pulmonares/cirurgia , Adulto , Analgésicos Opioides , Anestésicos Dissociativos , Encéfalo/efeitos dos fármacos , Estimulação Elétrica , Humanos , Ketamina , Neoplasias Pulmonares/imunologia , Neoplasias Pulmonares/fisiopatologiaRESUMO
The authors evaluated the capacities of transcranial electrostimulation and the specific features of its impact on reparative regeneration of damaged tissues of different types, such as the dermal and gastroduodenal epithelium, hepatic cells, connective tissue, peripheral nerve fibers, on animal experimental pathological models and compared with the results of treatment of respective pathology in patients.
Assuntos
Encéfalo/fisiologia , Queimaduras/terapia , Terapia por Estimulação Elétrica , Endorfinas/fisiologia , Perda Auditiva Neurossensorial/terapia , Infarto do Miocárdio/terapia , Úlcera Péptica/terapia , Regeneração/fisiologia , Adulto , Animais , Queimaduras/sangue , Criança , Terapia por Estimulação Elétrica/instrumentação , Terapia por Estimulação Elétrica/métodos , Eletrodos , Endorfinas/sangue , Perda Auditiva Neurossensorial/sangue , Humanos , Regeneração Hepática/fisiologia , Infarto do Miocárdio/sangue , Regeneração Nervosa/fisiologia , Úlcera Péptica/sangue , Ratos , Fatores de Tempo , Cicatrização/fisiologiaRESUMO
Noise at work impairs hearing with consequent occupational neurosensory deafness and general health disorders. Transcranial electric stimulation betters hearing and improves the workers' general state.
Assuntos
Terapia por Estimulação Elétrica/métodos , Perda Auditiva Neurossensorial/terapia , Doenças Profissionais/terapia , Adulto , Perda Auditiva Neurossensorial/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/diagnóstico , CrânioRESUMO
Hemodynamics was studied in 60 patients with pronounced initial hypovolemia, urgently operated on for acute gastrointestinal disease under conditions of 4 anesthesia. In contrast to traditional anesthesia, transcranial electric stimulation (TCES) as a component of anesthesia stabilized hemodynamics without increasing the rate and volume of intraoperative infusion therapy. This makes total anesthesia with TCES preferable in urgent operations, particularly in cases when hypovolemia cannot be properly corrected before surgery.
Assuntos
Abdome Agudo/cirurgia , Anestesia Geral/métodos , Hipovolemia/complicações , Idoso , Estimulação Elétrica , Emergências , Humanos , Pessoa de Meia-Idade , Fatores de Risco , Fatores de TempoAssuntos
Terapia por Estimulação Elétrica , Fadiga/fisiopatologia , Fadiga/psicologia , Adolescente , Adulto , Transtorno Depressivo/fisiopatologia , Transtorno Depressivo/psicologia , Transtorno Depressivo/terapia , Fadiga/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Placebos , Testes PsicológicosRESUMO
In randomised blind study with active placebo control in humans, rhythmic photostimulation of 77 Hz frequency did not elicit any fatigue or negative psychophysiological events as opposed to 50, 60, 100 Hz frequency. This and other findings are to be considered in designing rational systems of cinema projection and PC monitors.
Assuntos
Fadiga/psicologia , Adolescente , Adulto , Atenção , Computadores , Fadiga/etiologia , Feminino , Humanos , Masculino , Periodicidade , Estimulação Luminosa , Psicofisiologia/métodos , Distribuição Aleatória , Fatores de TempoRESUMO
Biochemical events of the rat hepatocytes cytolysis and deterioration of their synthetic activity and detoxification ability, as well as morphological events of lipid degeneration after acute poisoning with dichloretane and CCl4, were significantly reduced by effects of transcranial stimulation (TES). Blockade of the TES effects with naloxone revealed its endorphinergic nature. Combined effects of the TES and Essenciale preparation were lower than separate those of these agents. The TES effects were clinically corroborated in treatment of toxic hepatitis.
Assuntos
Encéfalo/metabolismo , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Endorfinas/metabolismo , Hepatócitos/metabolismo , Animais , Intoxicação por Tetracloreto de Carbono/metabolismo , Intoxicação por Tetracloreto de Carbono/patologia , Intoxicação por Tetracloreto de Carbono/fisiopatologia , Doença Hepática Induzida por Substâncias e Drogas/patologia , Doença Hepática Induzida por Substâncias e Drogas/fisiopatologia , Estimulação Elétrica , Dicloretos de Etileno , Fígado Gorduroso/patologia , Hepatócitos/patologia , Testes de Função Hepática , Masculino , Naloxona/farmacologia , Antagonistas de Entorpecentes/farmacologia , Fosfatidilcolinas/farmacologia , Substâncias Protetoras/farmacologia , Ratos , Ratos WistarRESUMO
A magnetic resonance imaging (MRI) method was used for a noninvasive study of current density (CD) and current pathways (CP's) inside the skull during transcranial electrostimulation in rabbits. The transcranial impulse current directions studied were those previously used in transcranial electric treatment either sagittally or bilaterally. MRI data were collected from slices perpendicular to the direction of current application. In these slices, only the perpendicular component of the CD was measured. Computer methods for accurate topographic mapping of the main areas with high CD and for reconstruction of CP's are described. It was revealed that current applied on the head sagittally passed mostly through the cerebrospinal fluid in the basal brain cisternas connected in series, and through the anterior horns of the lateral ventricles, foramina of Monro, ventrocaudal part of the third ventricle, aqueductus, and fourth ventricle. Possible connections between these CP's are suggested. Bilaterally applied current passed through the brain and skull core more diffusely without concentrations in cisternas and ventricles. The results of the present study suggest an explanation for the observation that sagittally applied current more effectively stimulates brain structures with antinociceptive function and elicits more pronounced analgesic effect.
Assuntos
Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Eletrofisiologia , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Crânio/anatomia & histologia , Crânio/fisiologia , Animais , Estimulação Elétrica , Eletrodos , CoelhosRESUMO
The paper deals with one type of electrostimulation-transcranial electrostimulation (TES). It outlines the physiological mechanisms underlying TES, the clinical features of its application, the equipment performing TES, defines its optimum analgesic mode.
Assuntos
Terapia por Estimulação Elétrica , Eletronarcose , Estimulação Elétrica Nervosa Transcutânea , Adulto , Animais , Gatos , Criança , Cães , Terapia por Estimulação Elétrica/instrumentação , Terapia por Estimulação Elétrica/métodos , Eletronarcose/instrumentação , Humanos , Camundongos , Coelhos , Ratos , Estimulação Elétrica Nervosa Transcutânea/instrumentação , TartarugasAssuntos
Encéfalo/fisiopatologia , Serotonina/fisiologia , Estimulação Elétrica Nervosa Transcutânea , 5-Hidroxitriptofano/farmacologia , 5-Hidroxitriptofano/uso terapêutico , Alopurinol/farmacologia , Alopurinol/uso terapêutico , Animais , Encéfalo/efeitos dos fármacos , Inibidores Enzimáticos/farmacologia , Inibidores Enzimáticos/uso terapêutico , Nialamida/farmacologia , Nialamida/uso terapêutico , Dor/tratamento farmacológico , Ratos , Ratos Wistar , Triptofano/farmacologia , Triptofano/uso terapêuticoAssuntos
Eletronarcose , Neurocirurgia , Anestesia Intravenosa , Animais , Estimulação Elétrica , Eletrodos , Humanos , Masculino , Ratos , Ratos WistarRESUMO
Metergoline and 5, 7-dihydroxytryptamine were found to suppress and to prevent an electroanalgesic effect, resp. An increase in the serotonine contents in the CSF after electroanalgesia suggests an activation of the brain serotoninergic system. DL-5-hydroxytryptophan and allopurinol enhanced the electroanalgetic effect. The data obtained suggests an existence of a serotoninergic component of the transcranial electroanalgesia mechanism.
Assuntos
Serotonina/fisiologia , Estimulação Elétrica Nervosa Transcutânea , Animais , Estimulação Elétrica , Masculino , Dor/etiologia , Dor/fisiopatologia , Manejo da Dor , Ratos , Ratos Wistar , Serotonina/líquido cefalorraquidiano , Antagonistas da Serotonina/farmacologia , Agonistas do Receptor de Serotonina/farmacologia , Fatores de TempoRESUMO
The mechanisms of inhibitory effect of transcranial electrostimulation in analgesic regime on blood pressor nociceptive reflexes were studied in experiments in rabbits and cats. Considerable inhibition of the late (bulbar) somato-sympathetic reflexes and spino-bulbo-spinal somato-somatic reflexes as well was demonstrated. The probable basis of sympatho-inhibition during transcranial electrical stimulation is a reduction of excitatory input to bulbar sympathoexcitatory neurons. It was revealed in experiments with inhibition of sympatho-excitation elicited by temporal brain ischaemia and local electrical stimulation of different bulbar ventrolateral vasomotor zones. The role of periaqueductal gray activated by transcranial electrical stimulation as a source of inhibition and its opioid mechanisms are discussed.