Multicenter cohort study to assess the impact of a silver-alloy and hydrogel-coated urinary catheter on symptomatic catheter-associated urinary tract infections.

PURPOSE: The purpose of this study was to determine the effect of a silver-alloy hydrogel catheter on symptomatic catheter-associated urinary tract infections (CAUTIs). DESIGN: Multicenter before-after non-randomized cohort study. SUBJECTS AND SETTING: Seven acute care hospitals ranging in size from 124 to 607 beds participated in this study. The study population included adult patients with a positive urine culture 2 or more days after admission, who underwent Foley catheterization. METHODS: Catheter-associated urinary tract infection surveillance was conducted at each hospital for at least 3 months during the use of a standard catheter and 3 months during the use of the silver-alloy hydrogel catheter. Both the National Healthcare Safety Network (NHSN) surveillance and a clinical definition of CAUTI were used for rate calculation. RESULTS: A 47% relative reduction in the CAUTI rate was observed with the silver-alloy hydrogel catheter compared to the standard catheter when both infection definitions were used (0.945/1000 patient days vs 0.498/1000 patient days) (odds ratio = 0.53; P < .0001; 95% CI: 0.45-0.62). When only NHSN-defined CAUTIs were considered, a 58% relative reduction occurred in the silver-alloy hydrogel period (0.60/1000 patient days vs 0.25/1000 patient days) (odds ratio = 0.42; P < .0001; 95% CI: 0.34-0.53). Antimicrobial days for CAUTIs decreased from 1165 (standard catheter period) to 406 (silver-alloy hydrogel period). CONCLUSIONS: Use of a silver-alloy hydrogel urinary catheter reduced symptomatic CAUTI occurrences as defined by both NHSN and clinical criteria.

A comprehensive hand hygiene approach to reducing MRSA health care-associated infections.

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infections are the most common health care-associated infections (HAI) in the acute care setting. The major mode of transmission from patient to patient is through bedside care providers via contaminated hands. After individual projects within Novant Health proved to be ineffective, with any gains in hand hygiene compliance being short-lived, a program was implemented to address unsatisfactory hand hygiene compliance rates. Published studies have associated improvements in hand hygiene compliance with decreases in HAIs. METHODS: A comprehensive systemwide program was developed with major program support from the education, marketing, clinical improvement, and clinical care departments. The key drivers of the program were the use of alcohol-based hand sanitizer and the system's dedication of resources to collect and report the compliance data. Monthly compliance rates were collected by two dedicated compliance monitors, and the results were shared across the system. In addition, MRSA HAI rates were followed for all the acute care facilities. RESULTS: Hand hygiene compliance rates increased from a baseline compliance of 49% to 98% for December 2008, with sustained rates greater than 90% since November 2006. More importantly, MRSA rates decreased from 0.52 HAIs per 1,000 patient days in 2005 to 0.24 HAIs per 1,000 patient days by year-end 2008. DISCUSSION: Understanding hand hygiene compliance is a simple matter of observing caregiver behavior during each hand hygiene opportunity and recording the actions taken. The improvements in hand hygiene compliance translated into a real decrease in the number of hospital-acquired MRSA infections.

Use of specific indicators to detect warfarin-related adverse events.

PURPOSE: The use of specific indicators, or "triggers," to identify adverse drug events (ADEs) associated with warfarin therapy is described. SUMMARY: Automated triggers provided by laboratory and pharmacy data were used to identify potential ADEs associated with warfarin therapy among patients treated in the emergency room or admitted to six community hospitals between July 2002 and December 2003. The triggers consisted of an International Normalized Ratio (INR) of greater than 3.0 and pharmacy orders for vitamin K. Pharmacists reviewed the triggers monthly for clinical determination of ADEs during preintervention and postintervention periods. Interventions consisted of staff education and real-time adjustments in therapy. A 39% overall reduction in ADEs occurred between the preintervention and postintervention periods. Harmful ADEs declined by 70%. CONCLUSION: INRs of greater than 3.0 and vitamin K administration appeared to be reliable indicators of warfarin-associated ADEs, and detection with these indicators appeared to reduce ADEs when combined with appropriate interventions.