[Visual impairment in elderly fallers]. / Déficit visuel chez les sujets âgés chuteurs.

OBJECTIVE: To study visual impairment and the etiology of visual loss in fallers and non-fallers in older patients. PATIENTS AND METHOD: Cross-sectional study including two groups of patients: elderly patients admitted for a fall (group 1) and elderly individuals who did not report a fall during the 6 months before admission (group 2). Visual acuity was measured in both eyes of all participants. Complete ophthalmologic evaluation was performed in the fallers group. RESULTS: The fallers group included 98 patients (mean age, 83.4 ± 6.3) and the non-fallers group included 106 patients (mean age, 79 ± 6.6). The fallers had lower vision than non-fallers (P<0.001). Visual impairment (visual acuity less than 20/40) was more frequent in the fallers (49.5% vs 15.3%, P<0.001). Causes of visual impairment in fallers were cataract (47.4%), association of cataract and age-related macular degeneration (17.5%), age-related macular degeneration without cataract (13.4%), and optic neuropathy (9.3%). Management of fallers was difficult, and only 17 of 48 eyes (35.4%) with cataract had undergone surgery. CONCLUSION: Fallers have a higher prevalence of visual impairment and blindness. Vision may improve with surgery in half of these eyes. This study highlights the need for systematic ophthalmologic evaluation in this high-risk population in order to prevent falls.

[Comparison of spectral analysis and non-linear analysis of EEG in patients with cognitive decline]. / Comparaison de l'analyse spectrale et de l'analyse non-linéaire de l'EEG dans les troubles cognitifs.

Twenty-five elder subjects were classified in two groups according to the MMS score and the cognitive evoked potentials. Normal subjects (n = 15) had mean MMS = 27.6 and mean P3 amplitude = 7.1 uV), while patients with cognitive decline (n = 10) had respective values of 18 (MMS) and 3.3 uV (P3). Spectral analysis and non-linear analysis of EEG (recurrence plots of dynamical systems) were performed and both showed statistically significant differences between groups for all the parameters analysed. Subjects' classification with discriminant analysis was slightly better using the non-linear parameters. The recurrence plot method applied to EEGs, gave similar results as the dimension of correlation (D2) calculation, and was in favour of a more constraint and less complex dynamics of brain activity associated with cognitive decline.

[Evaluation of lisinopril and lisinopril-hydrochlorothiazide combination in mild to moderate arterial hypertension]. / Evaluation du lisinopril et de l'association lisinopril-hydrochlorothiazide dans l'hypertension artérielle légère à modérée. Groupe de Travail Prinzide.

The main objective of this multicenter study was to compare the efficacy of an increase in dose and of a synergic combination in the 68 patients out of 126 (54%) with hypertension (DBP between 95 and 120 mm Hg after 2 weeks of placebo) who did not respond (DBP > or = 95 mmHg) to a 4-week treatment of 20 mg per day of lisinopril. Patients were randomized to receive a 4-week double-blind treatment of either 40 mg per day of lisinopril or the combination of 20 mg of lisinopril and 12.5 mg of hydrochlorothiazide per day. Mean reductions of systolic (inter-group comparison: p = 0.08) and diastolic BP (p = 0.006) as well as the proportion of responders (82% versus 45%, p < or = 0.01) were greater with the lisinopril-hydrochlorothiazide combination than with 40 mg of lisinopril. Tolerance was good in the 3 groups. The administration of a synergic combination is justified when hypertension is not controlled by a monotherapy.