1.
Bioorg Med Chem Lett
; 19(15): 4416-20, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19502058
RESUMO
Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.