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Biomed Res Int ; 2020: 5204348, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33344639

RESUMO

Zhibai Dihuang Wan (ZDW) is an eight-herbal formula of traditional Chinese medicine. Clinically, it regulated immune activity and was used to treat diabetes and renal disease. In this study, we aimed to explore the nephroprotective effect of ZDW in an aristolochic acid- (AA-) intoxicated zebrafish model. We used a green fluorescent kidney transgenic zebrafish to evaluate the nephroprotective effects of ZDW by recording subtle changes in the kidney. Our results demonstrated that ZDW treatment can attenuate AA-induced kidney malformations (60% for AA-treated, 47% for pretreatment with ZDW, and 17% for cotreatment ZDW with AA, n = 50). Furthermore, we found that the expression levels of tnfα and mpo were decreased either in pretreatment or cotreatment groups. In conclusion, our findings revealed that AA-induced nephrotoxicities can be attenuated by ZDW. Therefore, we believe that zebrafish represent an efficient model for screening AA-protective Chinese medicine.


Assuntos
Ácidos Aristolóquicos/toxicidade , Medicamentos de Ervas Chinesas/farmacologia , Nefropatias/tratamento farmacológico , Rim/efeitos dos fármacos , Substâncias Protetoras/farmacologia , Insuficiência Renal/induzido quimicamente , Animais , Animais Geneticamente Modificados , Perfilação da Expressão Gênica , Proteínas de Fluorescência Verde/metabolismo , Sistema Imunitário/efeitos dos fármacos , Nefropatias/metabolismo , Medicina Tradicional Chinesa , Fenótipo , ATPase Trocadora de Sódio-Potássio/metabolismo , Peixe-Zebra
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