Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism.

Black chokeberry or aronia (the fruit of Aronia melanocarpa) has been reported to having pharmacological activities against metabolic syndrome, such as hypertension, obesity, diabetes, and pro-inflammatory conditions. However, the effects of aronia on myogenic differentiation and muscle homoeostasis are uncharacterized. In this study, we investigated the effects of aronia (black chokeberry) on myogenic differentiation and muscle metabolic functions in young mice. Aronia extract (AR) promotes myogenic differentiation and elevates the formation of multinucleated myotubes through Akt activation. AR protects dexamethasone (DEX)-induced myotube atrophy through inhibition of muscle-specific ubiquitin ligases mediated by Akt activation. The treatment with AR increases muscle mass and strength in mice without cardiac hypertrophy. AR treatment enhances both oxidative and glycolytic myofibers and muscle metabolism with elevated mitochondrial genes and glucose metabolism-related genes. Furthermore, AR-fed muscle fibers display increased levels of total OxPHOS and myoglobin proteins. Taken together, AR enhances myogenic differentiation and improves muscle mass and function, suggesting that AR has a promising potential as a nutraceutical remedy to intervene in muscle weakness and atrophy.

Emotional states influence forward gait during music listening based on familiarity with music selections.

Music elicits a wide range of human emotions, which influence human movement. We sought to determine how emotional states impact forward gait during music listening, and whether the emotional effects of music on gait differ as a function of familiarity with music. Twenty-four healthy young adults completed walking trials while listening to four types of music selections: experimenter-selected music (unfamiliar-pleasant), its dissonant counterpart (unfamiliar-unpleasant), each participant's self-selected favorite music (familiar-pleasant), and its dissonant counterpart (familiar-unpleasant). Faster gait velocity, cadence, and stride time, as well as longer stride length were identified during pleasant versus unpleasant music conditions. Increased gait velocity, stride length, and cadence as well as reduced stride time were positively correlated with subjective ratings of emotional arousal and pleasure as well as musical emotions such as happiness-elation, nostalgia-longing, interest-expectancy, pride-confidence, and chills, and they were negatively related to anger-irritation and disgust-contempt. Moreover, familiarity with music interacted with emotional responses to influence gait kinematics. Gait velocity was faster in the familiar-pleasant music condition relative to the familiar-unpleasant condition, primarily due to longer stride length. In contrast, no differences in any gait parameters were found between unfamiliar-pleasant and unfamiliar-unpleasant music conditions. These results suggest emotional states influence gait behavior during music listening and that such effects are altered by familiarity with music. Our findings provide fundamental evidence of the impact of musical emotion on human gait, with implications for using music to enhance motor performance in clinical and performance settings.