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1.
Sci Prog ; 105(4): 368504221128776, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36200175

RESUMO

Blisks are not easily machined because of their complex curved surfaces and the high-precision requirements of surface machining. Lightweight alloy materials with superior mechanical properties, such as titanium alloy and stainless steel, are popular material choices for manufacturing turbine blisks. However, these materials are difficult to cut and require advanced machine tools and processing technologies. Because aerospace-grade parts are complex and require precise dimensions and high surface quality, machining these parts by using three-axis machine tools is difficult. Using multi-axis machine tools for the machining of complex parts can cause the achievement of precise dimensions, high quality, and the required surface roughness. In the multi-axis machining of aerospace blisks, tool path planning is considered the most difficult task. In this study, we examined the implementation of five-axis machining technology for the manufacturing of an aerospace blisk. Processing modules from computer-aided manufacturing software (NX10) are used for five-axis tool path generating, and 5-axis machining numerical control code is generated through post-processing calculations. Solid cutting simulation software (VERICUT) is used to verify whether tools exhibited overcut or interference. A sensory tool holder (SPIKE) is used to analyze cutting force during the rough machining of a blisk. The sensory tool holder is also adopted to evaluate the spindle runout and tool holding status. In order to obtain a consistent cutting allowance and surface accuracy, the online measurement system is used to generate a measurement path for semi-finish and finish machining. The real cut is performed with SUS304 and demonstrates the practical application. Through improvements in process planning, the machining time was shortened by 16.5%.

2.
Genes (Basel) ; 13(5)2022 04 25.
Artigo em Inglês | MEDLINE | ID: mdl-35627140

RESUMO

About 30-50% of oral cancer patients require mandibulectomy and autologous fibula reconstruction. Autograft is the gold standard choice because of its histocompatibility; however, it requires additional surgery from the patient and with possible complications such as loss of fibula leading to calf weakening in the future. Allograft and xenograft are alternatives but are susceptible to immune response. Currently, no personalized bone xenografts are available in the market for large fascial bone defects. In addition, a large-sized complex shape bone graft cannot be produced directly from the raw material. We propose the use of porcine bones with 3D CAD/CAM carving to reconstruct a personalized, wide range and complex-shaped bone. We anticipate that patients can restore their native facial appearance after reconstruction surgery. Supercritical CO2 (SCCO2) technology was employed to remove the cells, fat and non-collagenous materials while maintaining a native collagen scaffold as a biomedical device for bone defects. We successfully developed 3D CAD/CAM carved bone matrices, followed by SCCO2 decellularization of those large-sized bones. A lock-and-key puzzle design was employed to fulfil a wide range of large and complex-shaped maxillofacial defects. To conclude, the 3D CAD/CAM carved bone matrices with lock and key puzzle Lego design were completely decellularized by SCCO2 extraction technology with intact natural collagen scaffold. In addition, the processed bone matrices were tested to show excellent cytocompatibility and mechanical stiffness. Thus, we can overcome the limitation of large size and complex shapes of xenograft availability. In addition, the 3D CAD/CAM carving process can provide personalized tailor-designed decellularized bone grafts for the native appearance for maxillofacial reconstruction surgery for oral cancer patients and trauma patients.


Assuntos
Matriz Óssea , Neoplasias Bucais , Animais , Dióxido de Carbono , Xenoenxertos , Humanos , Suínos , Transplante Heterólogo
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