Patterns of patients with polypharmacy in adult population from Korea.

Polypharmacy and its rising global prevalence is a growing public health burden. Using a large representative nationwide Korean cohort (N = 761,145), we conducted a retrospective cross-sectional study aiming to identify subpopulations of patients with polypharmacy and characterize their unique patterns through cluster analysis. Patients aged ≥ 30 years who were prescribed at least one medication between 2014 and 2018 were included in our study. Six clusters were identified: cluster 1 mostly included patients who were hospitalized for a long time (4.3 ± 5.3 days); cluster 2 consisted of patients with disabilities (100.0%) and had the highest mean number of prescription drugs (7.7 ± 2.8 medications); cluster 3 was a group of low-income patients (99.9%); cluster 4 was a group of high-income patients (80.2%) who frequently (46.4 ± 25.9 days) visited hospitals/clinics (7.3 ± 2.7 places); cluster 5 was mostly elderly (74.9 ± 9.8 years) females (80.3%); and cluster 6 comprised mostly middle-aged (56.4 ± 1.5 years) males (88.6%) (all P < 0.001). Patients in clusters 1-5 had more prescribed medications and outpatient visit days than those in cluster 6 (all P < 0.001). Given limited health care resources, individuals with any of the identified phenotypes may be preferential candidates for participation in intervention programs for optimal medication use.

Solid-State Photochromism by Molecular Assembly of Bis-o-carboranyl Siloles.

A new type of solid-state photochromism was observed in an AB2 -type molecular assembly comprising a central silole and two peripheral o-carborane units, and in this assembly, depending on the assembling positions of those units at the adjoining benzene ring, two different regioisomers were formed: Si-m-Cb and Si-p-Cb. Each isomer showed different solid-state photochromism depending on its solid-state molecular conformation and was either in the crystalline or amorphous state. The crystals of each meta- or para-isomer, CSi-m-Cb or CSi-p-Cb , showed yellow or blue emission, and mechanically grinding those crystals into amorphous powders of ASi-m-Cb and ASi-p-Cb , switched their emissions to blue and yellow, respectively. Photophysical studies revealed that the electronic interaction between silole and o-carborane units determined the emission color. The crystal and DFT-optimized structures each account for the crystalline and amorphous structures, respectively, and are correlated well with the electronic interactions in the molecular assembly in the solid state, thus enabling the prediction of the solid-state molecular conformational change.