The Effect of Body Mass Index on Initial Breast Cancer Stage Among Korean Women.

BACKGROUND: The relationship between obesity and breast cancer stage is not well-known in the Korean population. This study aimed to identify the effect of body mass index (BMI) on initial breast cancer stage. PATIENTS AND METHODS: Among patients who underwent surgery for breast cancer (stages 0-III) from June 2003 to December 2018, we analyzed 4510 patients for whom there were BMI data. RESULTS: The average BMI of our patients was 23.5 (14.2-44.9). In total, 4.6% and 24.2% of the patients had a BMI of ≥30 and 25-29.9, respectively. In the patients with obesity, the proportion of T2 to T4 was 41.4%, which was higher than that in patients with a BMI of 25 to 29 (28.4%; P = .001) or a BMI of <25 (23.3%; P < .001). There was no difference in positive rates of estrogen receptor and progesterone receptor with BMI, but obese patients were less likely to be human epidermal growth factor receptor 2 positive. Patients with higher stages were more likely to have a higher BMI. The effect of BMI on stage was stronger in patients <50 years (odds ratio, 2.439; 95% CI, 1.783-3.335). Although there was no statistical significance, tumors >2 cm were less likely to be palpable in obese patients than in patients of normal weight (nonpalpable in 33.8% and 27.0%, respectively). CONCLUSION: Our study suggests that obesity is associated with a more advanced breast cancer stage, which represents a poor prognosis, and large tumors tend to be less palpable in women with obesity.

Intramuscular nerve distribution pattern of ankle invertor muscles in human cadaver using sihler stain.

INTRODUCTION: We sought to the ideal sites for botulinum toxin injection by examining the intramuscular nerve patterns of the ankle invertors. METHODS: A modified Sihler method was performed on the flexor hallucis longus, tibialis posterior, and flexor digitorum longus muscles (10 specimens each). The muscle origins, nerve entry points, and intramuscular arborization areas were measured as a percentage of the total distance from the most prominent point of the lateral malleolus (0%) to the fibular head (100%). RESULTS: Intramuscular arborization patterns were observed at 20-50% for the flexor hallucis longus, 70-80% for the tibialis posterior, and 30-40% for the flexor digitorum longus. CONCLUSIONS: These findings suggest that treatment of muscle spasticity of the ankle invertors involves botulinum toxin injections in specific areas. These areas, corresponding to the areas of maximum arborization, are recommended as the most effective and safest points for injection.

Detection and restoration of defective lines in the SPOT 4 SWIR band.

This paper presents the categorization and restoration of defective lines developed in pushbroom images. About 100 of the 3000 SPOT 4 SWIR detectors malfunction, which degrades image quality. Conventional methods have difficulties in effectively detecting and restoring defective lines, because they ignore the heterogeneity of the ground surface and the presence of sporadically unstable detectors with gain and offset that vary during a scan. While all defective lines have previously been considered as a single type, here they are categorized into three types according to the variation pattern in the scanning direction: constant defective lines, irregular defective lines, and irrecoverable defective lines. The detection procedure utilizes summed data and standard deviation data that consist of abnormal peaks originating from defective lines and a slowly varying baseline reflecting the surface characteristics within the image. The defective lines are detected by finding abnormal peaks, and classified and restored by using either a moment-matching method or interpolation, depending upon their types. Three SPOT 4 images were used to test and evaluate the performance of the proposed method. From the test results, the constant defective line was the most common type, comprising about 60%, while the irregular defective lines caused serious image degradation because of the difficulty of detecting and classifying them. Commission and omission errors were less than 10% and detection accuracy was higher than 90%. The analysis of signal-to-noise ratio (SNR) showed that the low SNR created by the defective lines was effectively removed. Our method gave a significant improvement of the detection and restoration capability.