Assuntos
Aspartato Aminotransferases/análise , Azatioprina/farmacologia , Transplante de Coração , L-Lactato Desidrogenase/análise , Miocárdio/enzimologia , Animais , Aspartato Aminotransferases/sangue , Cães , Reação Enxerto-Hospedeiro , Coração/efeitos dos fármacos , Hidrocortisona/farmacologia , Terapia de Imunossupressão , Isquemia , Isoenzimas , L-Lactato Desidrogenase/sangue , Imunologia de Transplantes , Transplante HomólogoAssuntos
Infertilidade Masculina/terapia , Anticorpos/análise , Biópsia , Clomifeno/uso terapêutico , Fluoximesterona/uso terapêutico , Humanos , Infertilidade Masculina/tratamento farmacológico , Infertilidade Masculina/etiologia , Infertilidade Masculina/cirurgia , Síndrome de Klinefelter/complicações , Masculino , Sêmen , Espermatozoides/imunologia , Testículo/patologia , Vitamina B 12/uso terapêuticoAssuntos
Adenocarcinoma/etiologia , Íleo , Neoplasias Intestinais/etiologia , Derivação Urinária/efeitos adversos , Adenocarcinoma/patologia , Adulto , Carcinoma/etiologia , Feminino , Humanos , Íleo/patologia , Íleo/cirurgia , Tuberculose Urogenital/cirurgia , Bexiga Urinária/patologia , Bexiga Urinária/cirurgiaRESUMO
A case of primary rhabdomyosarcoma in the right cerebral hemisphere of a 45 year old woman is reported. This was treated by surgical excision but death occurred 10 months after the first symptom. The histogenesis of such a tumour is discussed. The clinical and pathological features of 15 previously reported similar tumours of the CNS are compared. Most of these occurred in the cerebellum in children where they have been regarded as medullomyoblastomas (a variant of medulloblastoma), teratomas, or rhabdomyosarcomas. Few have been recorded in adults and only one previously in the cerebrum. All of these tumours tend to have a short clinical course, although survival time seems to be significantly improved by surgical excision followed by radiotherapy. The remarkable morphological similarities between the tumours are discussed. Argyrophilic fibrils were demonstrated in the present case and in an unrelated rhabdomyosarcoma of the jaw. This observation may invalidate the main criterion used for separating medullomyoblastomas and teratomas from rhabdomyosarcomas in this group of tumours. It is concluded that at present all these tumours should be regarded as rhabdomyosarcomas.
Assuntos
Neoplasias Encefálicas/patologia , Córtex Cerebral/patologia , Meduloblastoma/patologia , Rabdomiossarcoma/patologia , Neoplasias Encefálicas/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias Maxilomandibulares/patologia , Meduloblastoma/diagnóstico , Pessoa de Meia-Idade , Rabdomiossarcoma/diagnósticoAssuntos
Transplante de Coração , Miocárdio/patologia , Imunologia de Transplantes , Animais , Azatioprina/uso terapêutico , Biópsia , Cães , Rejeição de Enxerto , Hidrocortisona/uso terapêutico , Imunidade Celular , Métodos , Miocárdio/imunologia , Necrose/etiologia , Necrose/imunologia , Transplante HomólogoRESUMO
The histology of the parathyroids from 88 cases of primary hyperparathyroidism has been reviewed in a search for local amyloid deposits. Characteristic intrafollicular amyloid deposits of varying extent were found in nine cases. The case histories of these show that seven had suspected or proven pluriglandular adenomatosis but that the remainder had no such associations. The material studied shows no correlation with systemic primary or secondary amyloidosis. The significance of these findings is discussed in relation to the pluriglandular syndrome, peptide hormones, medullary carcinoma of the thyroid, and calcitonin secretion. It is suggested that amyloid in this context may be a ;marker' for secretion of a peptide closely related to calcitonin.
