1.
Curr Opin Genet Dev
; 13(2): 207-14, 2003 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12672499
RESUMO
In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.