RESUMO
Renal impairment at the time of heart transplantation complicates the choice of subsequent immunosuppressive therapy. Calcineurin (CNI)-free regimens utilizing proliferation signal inhibitors (PSI) may mitigate against nephrotoxicity in this group; however, their effectiveness remains unclear. We present our 7-year experience with de novo CNI-free, PSI-based immunosuppression after heart transplantation. Of the 152 patients transplanted between July 1999 and July 2006, de novo immunosuppression regimens were 49 CNI-free, PSI-based, 88 CNI, 15 combination of CNI+PSI. Pretransplant creatinine clearance improved within 6 months in the PSI group (0.69 +/- 0.34 mL/s vs. 1.00 +/- 0.54 mL/s, p < 0.05) but not the CNI (1.32 +/- 0.54 mL/s vs. 1.36 +/- 0.53 mL/s, p = ns) or CNI+PSI (1.20 +/- 0.24 mL/s vs. 1.20 +/- 0.41 mL/s, p = ns) groups. The PSI group had more episodes of early (Assuntos
Transplante de Coração
, Imunossupressores/uso terapêutico
, Adulto
, Infecções Bacterianas/complicações
, Infecções Bacterianas/tratamento farmacológico
, Creatinina/urina
, Infecções por Citomegalovirus/prevenção & controle
, Feminino
, Rejeição de Enxerto
, Humanos
, Testes de Função Renal
, Masculino
, Pessoa de Meia-Idade
, Estudos Retrospectivos
, Análise de Sobrevida