RESUMO
We have investigated the interface between bone and chronic implants of nacre in sheep. There was no foreign body reaction over the period of 10 months and the implants were not broken down. Light microscopy indicated activity within an osteoprogenitor cellular layer lining the implant, resulting in a complete sequence of new bone formation. Nacre appeared to bind directly to newly formed bone without any intervening fibrous tissue. Scanning electron microscopy and energy dispersive photon X-microanalysis showed calcium and phosphate ions lining the nacre within the osteoprogenitor tissue. These studies show a dynamic activity of the bone/nacre interface, leading to continuity between the nacre and the bone.
Assuntos
Materiais Biocompatíveis , Substitutos Ósseos , Transplante Ósseo/métodos , Transplante Ósseo/patologia , Animais , Transplante Ósseo/fisiologia , Cálcio/metabolismo , Microanálise por Sonda Eletrônica , Masculino , Teste de Materiais , Osseointegração/fisiologia , Ostreidae/anatomia & histologia , Fósforo/metabolismo , OvinosAssuntos
Colonoscopia , Transmissão de Doença Infecciosa , Contaminação de Equipamentos , Hepatite C/transmissão , Sequência de Bases , Colonoscópios , Desinfecção , Feminino , Genótipo , Hepacivirus/genética , Hepacivirus/isolamento & purificação , Hepatite C/diagnóstico , Hepatite C/virologia , Humanos , Masculino , Pessoa de Meia-Idade , Dados de Sequência Molecular , RNA Viral/sangueRESUMO
Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. gonorrhoeae and N. meningitidis and was found to contain approximately 1 mole of Fe /mole of protein. Sera from patients with gonococcal infections contained antibodies to the MIRP. Thus, the MIRP is expressed in vivo. The iron-binding nature of the MIRP suggests that it may have a role in iron acquisition by the pathogenic Neisseria species and, therefore, may have a function in their pathogenicity.
Assuntos
Proteínas da Membrana Bacteriana Externa/análise , Proteínas de Bactérias , Gonorreia/microbiologia , Infecções Meningocócicas/microbiologia , Neisseria/patogenicidade , Sequência de Aminoácidos , Proteínas da Membrana Bacteriana Externa/biossíntese , Humanos , Ferro/metabolismo , Proteínas de Ligação ao Ferro , Dados de Sequência Molecular , Neisseria/metabolismo , Neisseria gonorrhoeae/metabolismo , Neisseria gonorrhoeae/patogenicidade , Neisseria meningitidis/metabolismo , Neisseria meningitidis/patogenicidade , Proteínas Periplásmicas de Ligação , VirulênciaRESUMO
Bronchopulmonary infections has been described for the most part in adults. ORL and upper respiratory tract infections are encountered in children. In neonates, only conjunctivitis have been reported. In their report, the authors describes the first cases of bronchopulmonary infections due to Branhamella Catarrhalis in premature infants with respiratory distress syndrome. Three cases are described in which this bacteria has been isolated in bronchial secretions and in the culture of the nasotracheal tube. Clinical and biological features were not specific. Only orosomucoid serum level was increased. A favourable outcome was obtained by macrolides. Epidemiological survey permitted the isolation of Branhamella Catarrhalis in one of the nurse who had taken care of the neonates. Otherwise, these infections occurs in immunologically compromised hosts. Hyaline membrane disease appears most likely as an auspicious factor.
