Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 8 de 8
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
2.
Interv Neuroradiol ; 19(1): 67-72, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23472726

RESUMO

Developmental venous anomalies (DVA) drain normal neural tissue and are mostly discovered incidentally. We describe a young patient with a left hemisphere superficial to deep DVA and right hemisphere venous outflow restriction presenting with a seizure. The right hemisphere drainage variation is not typical of a DVA but represents another drainage pattern on the border of normality.


Assuntos
Angioma Venoso do Sistema Nervoso Central/diagnóstico por imagem , Angioma Venoso do Sistema Nervoso Central/patologia , Veias Cerebrais/anormalidades , Lateralidade Funcional , Adolescente , Angiografia Cerebral , Epilepsia Tônico-Clônica/diagnóstico por imagem , Epilepsia Tônico-Clônica/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Tomografia Computadorizada por Raios X
3.
Ann Oncol ; 24(6): 1697-703, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23439861

RESUMO

BACKGROUND: Ipilimumab is a recently approved immunotherapy that has demonstrated an improvement in the overall survival (OS) of patients with metastatic melanoma. We report a single-institution experience in patients treated in a compassionate-use program. PATIENTS AND METHODS: In this prospective study, patients were treated between June 2010 and September 2011. Inclusion criteria were a diagnosis of unresectable stage III or IV melanoma, at least one previous line of chemotherapy, and survival 12 weeks after the first perfusion. Four courses of ipilimumab were administered at a dose of 3 mg/kg every 3 weeks. RESULTS: Seventy-three patients were included. Median OS was 9.1 months (95% CI 6.4-11.3) from the start of ipilimumab. Immune-related adverse events were observed in 45 patients (62%), including 19 grade 3-4 events (26%). No drug-related death occurred. A lymphocyte count >1000/mm(3) at the start of the second course and an increase in the eosinophil count >100/mm(3) between the first and second infusions were correlated with an improved OS. CONCLUSION: Ipilimumab toxic effect is manageable in real life. Biological data such as lymphocyte and eosinophil counts at the time of the second ipilimumab infusion appear to be early markers associated with better OS.


Assuntos
Anticorpos Monoclonais/administração & dosagem , Eosinófilos/metabolismo , Linfócitos/metabolismo , Melanoma/tratamento farmacológico , Neoplasias Cutâneas/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Eosinófilos/efeitos dos fármacos , Eosinófilos/patologia , Feminino , Humanos , Ipilimumab , Contagem de Linfócitos , Linfócitos/efeitos dos fármacos , Linfócitos/patologia , Masculino , Melanoma/mortalidade , Melanoma/patologia , Pessoa de Meia-Idade , Estudos Prospectivos , Neoplasias Cutâneas/mortalidade , Neoplasias Cutâneas/patologia , Taxa de Sobrevida/tendências , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
4.
Interv Neuroradiol ; 18(2): 178-86, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22681733

RESUMO

Posttraumatic carotid cavernous fistulae are abnormal direct hole communications between the intracavernous carotid artery and the cavernous sinus that can result from both blunt and penetrating trauma. They can be challenging lesions to treat and a variety of modalities and approaches have been proposed since endovascular treatment has become the standard treatment. An analysis of the angioarchitecture of 32 consecutive patients treated in our service demonstrated that seven could be classified as small hole, eight medium and 17 large. Different size fistulae required varying endovascular tools. Small fistulae were best treated using coils and large and medium lesions with balloons. Large lesions were more likely to require multiple tools in order to achieve closure and had a lower chance of ipsilateral carotid preservation. All patients in the series were cured with a carotid preservation rate of 66%. There was no permanent morbidity associated with endovascular treatment.


Assuntos
Fístula Carótido-Cavernosa/etiologia , Fístula Carótido-Cavernosa/terapia , Traumatismos Craniocerebrais/complicações , Embolização Terapêutica/métodos , Procedimentos Endovasculares/métodos , Adolescente , Adulto , Idoso , Angiografia Digital , Angiografia Cerebral , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
5.
Biochim Biophys Acta ; 1760(6): 951-8, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16527409

RESUMO

Dietary polyphenols have received attention for their anti-oxidative, anti-carcinogenic and anti-neurodegenerative effects. Polyphenols bind to proteins leading to the formation of soluble or insoluble protein-polyphenol complexes which could significantly influence their biological activities. NMR and molecular modeling studies were performed to investigate the influence of the bulk, flexibility and hydrophobicity of polyphenols on the association with bradykinin, the peptide model. Our results show that the strength of the interactions could be positively correlated with polyphenol hydrophobicity and a comparison between pentagalloylglucose and vescalagin indicated that flexibility might play a positive role in the interaction with peptides and proteins.


Assuntos
Bradicinina/química , Bradicinina/metabolismo , Flavonoides/química , Flavonoides/metabolismo , Fenóis/química , Fenóis/metabolismo , Compostos de Bifenilo/química , Catecóis/química , Taninos Hidrolisáveis/química , Interações Hidrofóbicas e Hidrofílicas , Espectroscopia de Ressonância Magnética , Modelos Moleculares , Maleabilidade , Polifenóis , Conformação Proteica , Prótons
6.
Interv Neuroradiol ; 11(4): 341-8, 2005 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-20584446

RESUMO

SUMMARY: With the establishment of endovascular coiling as a successful treatment for symptomatic cerebral aneurysms, attention is now being directed at the durability of this treatment. If this is to be accurately done it will be important to understand the causes of symptomatic aneurysm presentation after previous treatment. In order to assess this we undertook a retrospective review, covering the four year period from 2000 to 2004, of all patients re-presenting with a symptomatic saccular aneurysm after previous treatment. Seven patients were identified, six presenting with subarachnoid haemorrhage (SAH) and one with a third cranial nerve palsy. Three patients had incomplete clipping of their aneurysms and all presented within months of their initial treatment. The other four patients presented between five and 20 years after primary treatment and all were felt to have new cerebral aneurysms. Two of these patients had aneurysms develop at the same location as their previously treated lesions, however these were still felt to be new aneurysms rather than re-growth or recurrence because of their morphology. Based on our findings it would appear that development of a new cerebral aneurysm after clipping is more of a risk than aneurysm recurrence from treatment failure. This will need to be considered when evaluating re-presentation after treatment by either coiling or clipping and more importantly, perhaps we should be directing more attention to preventing disease progression rather than treatment failure.

7.
Interv Neuroradiol ; 11(4): 387-91, 2005 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-20584453

RESUMO

SUMMARY: There are many reasons for patients infected with human immunodeficiency virus (HIV) to develop cerebrovascular disease. The HIV virus itself however may be a cause of vessel wall pathology. We present a clinical and pathological study of a patient who was HIV positive and presented with a subarachnoid haemorrhage. Cerebral angiography and later histology confirm that there was extensive vessel wall injury with dissection and a false aneurysm of the right middle cerebral artery.

8.
Interv Neuroradiol ; 10(2): 137-43, 2004 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-20587225

RESUMO

SUMMARY: Cerebrovascular complications of AIDS have been reported as high as 34% in post mortem series. Most patients suffer from ischaemic strokes but there are a number of reports of patients presenting with subarachnoid haemorrhage (SAH) related specifically to aneurysm rupture. We present three patients with advanced HIV disease and low CD4 counts who present with SAH. In two of the patients the haemorrhage appeared to be caused by intracranial artery dissection which, to our knowledge, has not previously been described. Both patients were successfully treated endovascularly, one with segmental vessel trapping and the other with partial coil embolization of a false aneurysm. The pathological basis for HIV related arteriopathy is discussed in relation to these cases.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...