Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Dev Cell ; 56(4): 540-556.e8, 2021 02 22.
Artigo em Inglês | MEDLINE | ID: mdl-33621494

RESUMO

We have analyzed the link between the gene regulation and growth during the early stages of flower development in Arabidopsis. Starting from time-lapse images, we generated a 4D atlas of early flower development, including cell lineage, cellular growth rates, and the expression patterns of regulatory genes. This information was introduced in MorphoNet, a web-based platform. Using computational models, we found that the literature-based molecular network only explained a minority of the gene expression patterns. This was substantially improved by adding regulatory hypotheses for individual genes. Correlating growth with the combinatorial expression of multiple regulators led to a set of hypotheses for the action of individual genes in morphogenesis. This identified the central factor LEAFY as a potential regulator of heterogeneous growth, which was supported by quantifying growth patterns in a leafy mutant. By providing an integrated view, this atlas should represent a fundamental step toward mechanistic models of flower development.


Assuntos
Arabidopsis/crescimento & desenvolvimento , Arabidopsis/genética , Flores/crescimento & desenvolvimento , Flores/genética , Arabidopsis/citologia , Proteínas de Arabidopsis/genética , Proteínas de Arabidopsis/metabolismo , Padronização Corporal/genética , Linhagem da Célula/genética , Flores/anatomia & histologia , Flores/citologia , Regulação da Expressão Gênica no Desenvolvimento , Regulação da Expressão Gênica de Plantas , Redes Reguladoras de Genes , Genes de Plantas , Morfogênese/genética , Mutação/genética
2.
Entropy (Basel) ; 22(1)2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-33285837

RESUMO

In the general framework of d 1 × d 2 mixed states, we derive an explicit bound for bipartite negative partial transpose (NPT) entanglement based on the mixedness characterization of the physical system. The derived result is very general, being based only on the assumption of finite dimensionality. In addition, it turns out to be of experimental interest since some purity-measuring protocols are known. Exploiting the bound in the particular case of thermal entanglement, a way to connect thermodynamic features to the monogamy of quantum correlations is suggested, and some recent results on the subject are given a physically clear explanation.

3.
Science ; 369(6500)2020 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-32646972

RESUMO

Marine invertebrate ascidians display embryonic reproducibility: Their early embryonic cell lineages are considered invariant and are conserved between distantly related species, despite rapid genomic divergence. Here, we address the drivers of this reproducibility. We used light-sheet imaging and automated cell segmentation and tracking procedures to systematically quantify the behavior of individual cells every 2 minutes during Phallusia mammillata embryogenesis. Interindividual reproducibility was observed down to the area of individual cell contacts. We found tight links between the reproducibility of embryonic geometries and asymmetric cell divisions, controlled by differential sister cell inductions. We combined modeling and experimental manipulations to show that the area of contact between signaling and responding cells is a key determinant of cell communication. Our work establishes the geometric control of embryonic inductions as an alternative to classical morphogen gradients and suggests that the range of cell signaling sets the scale at which embryonic reproducibility is observed.


Assuntos
Urocordados/citologia , Urocordados/embriologia , Animais , Comunicação Celular , Divisão Celular , Rastreamento de Células , Reprodução
4.
Nat Commun ; 10(1): 2812, 2019 06 27.
Artigo em Inglês | MEDLINE | ID: mdl-31249294

RESUMO

Powerful novel imaging and image-processing methods are revolutionizing many fields of biology, at scales ranging from the molecule to the functional organ. To support this big-data revolution, we develop a concept of generic web-based morphodynamic browser to interactively visualize complex image datasets, with applications in research and education. MorphoNet handles a broad range of natural or simulated morphological data, onto which quantitative geometric or genetic data can be projected.


Assuntos
Bases de Dados Genéticas , Internet , Navegador , Software
5.
Phys Rev E ; 93(2): 022122, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26986303

RESUMO

We propose a quantum Otto cycle based on the properties of a two-level system in a realistic out-of-thermal-equilibrium electromagnetic field acting as its sole reservoir. This steady configuration is produced without the need of active control over the state of the environment, which is a noncoherent thermal radiation, sustained only by external heat supplied to macroscopic objects. Remarkably, even for nonideal finite-time transformations, it largely over-performs the standard ideal Otto cycle and asymptotically achieves unit efficiency at finite power.

6.
Phys Rev E ; 93(2): 022134, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26986315

RESUMO

We study the functioning of a three-level thermal machine when acting on a many-qubit system, the entire system being placed in an electromagnetic field in a stationary out-of-thermal-equilibrium configuration. This realistic setup stands between the two so-far-explored cases of single-qubit and macroscopic object targets, providing information on the scaling with system size of purely quantum properties in thermodynamic contexts. We show that, thanks to the presence of robust correlations among the qubits induced by the field, thermodynamic tasks can be delivered by the machine both locally to each qubit and collectively to the many-qubit system: This allows a task to be delivered also on systems much bigger than the machine size.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...