Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritis.

AIM: To investigate potential predictors of response to conventional DMARDs in RA. METHODS: Study design - 6-month follow-up prospective study. PARTICIPANTS: RA patients with active disease. INTERVENTION AND FOLLOW-UP: Introduction of one DMARD. Response to treatment evaluated at 6 months (ACR20 criteria). ANALYSIS: Potential predictors of response, patients' demographics, disease activity, percentages of PBMC subsets expressing P-gp, serum IL-1ß, IL-6, IL-8, IL-10, IL-12, TNF-α levels, were evaluated using univariate and multivariate logistic regression analysis. ROC curve analyses were performed in order to obtain thresholds allowing the prediction of response. RESULTS: Forty-two patients (mean age = 57 ± 13 years, mean disease duration = 5.4 ± 7.2 years) were included. MTX was given to 30. The response to therapy was predicted by the baseline serum level of TNF-α (mean = 30.2 pg/ml ± 18 in non-responders vs. 11.9 pg/ml ± 11.2 in responders). The threshold, which predicted with the best accuracy the response to treatment, was 20.1 pg/ml (sensitivity, specificity, positive and negative predictive values of 75, 78.9, 83.3, and 69.2%, respectively; AUC = 80.3%, 95% CI = 62.8-97.7%). Similar results were obtained in the subgroups of patients treated with MTX and patients with early RA of less than 3 years duration. CONCLUSION: In the present work, the serum concentration of TNF-α was related to further response to DMARDs. Other works are needed for confirmation and to assess whether such biomarker could be used to predict the response to DMARDs at the individual level.

Chronic Brucella infection of the humerus diagnosed after a spontaneous fracture.

Brucellosis is uncommon in humans and only rarely manifests as osteomyelitis. We report the case of a 57-year-old patient with chronic Brucella osteomyelitis of both humeri. The diagnosis was established upon evaluation of a spontaneous fracture of the right humerus. The organism was recovered in fluid draining to the skin from an abscess located in the bone and soft tissues.

Coexistence of intravertebral vacuum and intradiscal vacuum.

INTRODUCTION: The pathophysiology of intravertebral vacuum (IVV) remains unclear, although vertebral osteonecrosis is often incriminated. Gas may migrate from the disk to the vertebral body. The objective of this study was to investigate the relations between IVV and intradiscal vacuum (IDV). METHODS: We prospectively evaluated the presence of radiological findings suggestive of IVV in patients admitted to a rheumatology department for vertebral fracture, over a 6-year period. Suggestive radiological findings were defined as a radiolucent collection within a vertebral body, an increase in the anteroposterior diameter of the vertebral body, and/or evidence of horizontal dissection of a vertebral body. Patients with any of these findings underwent computed tomography; when this investigation showed IVV, the adjacent disks were examined for IDV, and when this was found a communication between the two cavities was looked for. RESULTS: Of 278 patients admitted for vertebral fracture during the study period, 15 had IVV. IDV adjacent to the fractured endplate was visible in 13 of these 15 patients. All 15 patients had severe fractures (Genant semi-quantitative classification, grade 3 in 10 patients and grade 2 in five patients). A communication between the intradiscal and intravertebral collections was seen in five patients. Only two patients had evidence of IVV on plain radiographs. CONCLUSION: Our findings support migration of gas from the disk to a fracture in the adjacent vertebral body. The term "vertebral osteonecrosis" used to designate IVV may be inappropriate. IVV is rarely shown by plain radiographs, indicating a need for other morphological criteria.

"Occult" osteoporotic vertebral fractures: vertebral body fractures without radiologic collapse.

STUDY DESIGN: Retrospective observational study. OBJECTIVES: We report our experience with patients who presented with osteoporotic vertebral fractures with no visible deformation of vertebral body. SUMMARY OF BACKGROUND DATA: The diagnosis of osteoporotic vertebral fractures largely relies on the observation of vertebral deformations on plain radiographs, termed vertebral collapses. There are no data on the characteristics, or indeed of the reality, of osteoporotic vertebral fractures with no significant deformation of the vertebral body. METHODS: We retrospectively analyzed cases that presented with acute back pain with no initial deformation of the vertebral body on plain radiographs, and later proved to be fresh osteoporotic vertebral body fractures. All cases met each of the following criteria: 1) The incriminated vertebra appeared normal on initial radiographs (Genant's Grade 0 deformation). 2) The diagnosis of fresh vertebral body fracture was confirmed by MRI. 3) The diagnosis of osteoporosis was made by the combination of established osteoporosis, ruling out of underlying disease, and follow-up. RESULTS: We observed 21 fractures in 16 patients (11 female/5 male; mean age, 72 years). Most of these fractures affected the lumbar spine (14 of 21 occurred at L2-L5). Osteoporosis was known beforehand in 9 patients and newly diagnosed in 7 patients. At follow-up, radiographs were obtained for 19 of 21 fractures: in 15 cases, the vertebral fracture developed a vertebral collapse (Genant's Grade > or = 0.5) in a mean of 12.5 weeks (range, 4-24 weeks); in the 4 remaining cases, the vertebra remained normal. All cases had a clinically favorable outcome. CONCLUSION: Osteoporotic vertebral fractures with no sign of vertebral collapse on initial radiographs do indeed exist. They are analogous to occult stress fractures well known in other skeletal sites. They must not be misdiagnosed as malignant lesions.

Bilateral symmetric polyarthralgia revealing Fanconi's syndrome.

We report the case of a 45-year-old woman who presented with a six-year history of diffuse polyarthralgia responsible for major disability. She reported bilateral symmetric arthralgia in nearly every joint, as well as back pain. Muscle wasting predominating in the roots of the limbs was found. Laboratory tests showed hypocalcemia, severe hypophosphatemia, hypokalemia, alkaline phosphatase elevation, aminoaciduria, and hyperphosphaturia, with no glycosuria. Radiographs disclosed osteolysis of the pubic symphysis, multiple pelvic fractures, vertebral compression fractures, and diffuse demineralization. A bone scan visualized symmetric foci of hyperactivity in nearly all joints and fracture sites. Dramatic improvements in clinical and radiographic abnormalities were noted after six months of treatment with phosphate and calcitriol. This is a case of incomplete Fanconi syndrome, with no glycosuria. The clinical presentation of Fanconi syndrome can be misleading. Fanconi syndrome should be borne in mind as a possible cause of polyarthralgia to avoid diagnostic delay, which in our patient led to a picture of pseudomyopathy with multiple fractures.