1.
Chirality
; 11(10): 768-71, 1999.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10561706
RESUMO
The enantiomers of 7-des-methyl-ormeloxifene were separated by countercurrent chromatography (CCC) using sulfated beta-cyclodextrin as chiral selector, representing the first reported successful application of a cyclodextrin derivative in CCC-based resolutions. The choice of chiral selector relies on extreme separation factors observed in chiral capillary electrophoresis, and suitable CCC conditions were developed employing an analytical toroidal coil countercurrent chromatograph. Preparative separation of the enantiomers was performed using a conventional, preparative CCC-instrument. Copyright 1999 Wiley-Liss, Inc.