Tiapride is more effective and causes fewer adverse effects than risperidone in the treatment of senile dementia.

OBJECTIVE: We wanted to compare the effects of tiapride and risperidone in treating behavioral and psychological symptoms of senile dementia. PATIENTS AND METHODS: 108 patients with senile dementia received respective treatments (54 patients per treatment, either with 100 mg/day risperidone or 2.0 mg tiapride/day) for 2 months. Outcomes included the positive and negative syndrome scale (PANSS) scores, the curative rate of senile dementia, and prevalence of adverse effects (somnolence, headache, loss of weight, extrapyramidal system response, irritation and insomnia). RESULTS: PANSS scores before treatment were comparable between treatment groups. On days 7, 15, 30, and 60 of the treatment, the differences between two treatment groups became evident. Thus, curative rates in patients treated with risperidone were 74.1% and in those treated with tiapride 88.9% (p < 0.05). Prevalence of adverse reactions was significantly lower in the latter group (9.3% vs. 25.9% in patients treated with risperidone; p < 0.05). CONCLUSIONS: Tiapride is more effective in improving clinical symptoms of senile dementia and causes fewer adverse effects.

[Effect of intravenous injection of intravenous injection of chlorine on blood oxygen saturation in patients with nasal endoscopic surgery].

Objective:To observe the effect of intravenous injection of chlorine on postoperative analgesia and blood oxygen saturation in patients with nasal endoscopic surgery.Method:According to the standard of American Society of anesthesiologists(ASA) grading assessment for Ⅰ-Ⅱ, undergoing nasal endoscopic surgery of 120 patients were randomly divided into two groups, 60 cases in each group. Control group dezocine 0.8 g/kg+ physiological saline to 100 ml; on the basis of the experimental group with flurbiprofen 2 mg/kg+ physiological saline to 100 ml. Respectively in the postoperative recovery and postoperative 2, 4, 12, 24 and 48 h recording vital signs, pain scores(visual analogue score, VAS) and sedation score(Ramsay score) and observe the adverse reaction rate and patient surveys on the satisfaction of postoperative analgesia.Result:The two groups compared test of TKA group after 4, 8, 12, 24, 36 h, 48 h, 72 h resting VAS score and postoperative 24 h, 48 h, 72 h activities of VAS score were lower than the control group, the difference is statistically significant (F=1 873.26, P< 0.05). After 2 h, 6 h, 2 groups of pH, PaO2, PaCO2, SpO2 compared statistically significant (P> 0.05). After 24h, 48h after test group, PaO2, PaCO2, SpO2 is better than that of the control group(P< 0.05); after 6 h, 24 h, 48 h after the test group patients Ramsay Sedation score than the control group, the difference is statistically significant(F=1 031.35, P< 0.05). The experimental group after TKA patients of pain control education satisfaction and to control or reduce pain method of satisfaction were superior to the control group, the difference significant (χ²=11.02, P< 0.05;χ²=9.33, P< 0.05).Conclusion:The application of intravenous injection of intravenous injection of chlorine in the postoperative pain of nasal endoscopic surgery can significantly improve the analgesic effect, improve the blood gas analysis, improve the analgesic effect, it is worthy of popularization and application.

Mutation analysis of the TATA box-binding protein (TBP) gene in Chinese Han patients with spinocerebellar ataxia.

Spinocerebellar ataxia type 17 (SCA17) is a rare autosomal dominant progressive neurodegenerative disease caused by the CAG/CAA expansion in the TATA box-binding protein (TBP) gene. This study aimed to assess the frequency of SCA17 in patients from mainland China. Analysis of CAG/CAA expansion in this gene was performed in 263 patients consisting of 100 probands with dominantly inherited ataxias and 163 patients with sporadic ataxias. Abnormal expansion of CAG/CAA repeats in the SCA17 locus was found in a proband and her younger sister. To our knowledge, we are providing the first kindred analysis of SCA17 in mainland China.

[Effect of gossypol on the proliferation of rat prostate cells studies in vivo and in vitro].

The effect of gossypol on prostate cells of rat was studied both in vitro and in vivo. For in vivo study, mature male Sprague Dawley rats were given gossypol orally, 5 mg/day, 5 times a week for one month. Then the prostates were examined histologically. By adding gossypol to the culture system directly, NbE-1 cells were used in vitro study. Several parameters, including histological structure, cell growth, DNA synthesis and mitotic cycle of cells were measured by different methods. The prostate size and weight in experimental rats decreased and significant differences between acini in controls and gossypol treated animals were noted. Acini of control prostate were full of protruding folds constituted by columnar epithelial cells, whereas, the most of the acini in treated animals were composing of cubic or square epithelial cells and epithelial folds were rarely seen. Thus, acini with normal appearance were about 14% less than that in controls. In the in vitro experiments, both cell proliferation and DNA synthesis decreased from 0 to 80% and from 0 to 90% respectively, when the concentrations of gossypol were increased from 0 to 20 micrograms/ml. It seems that 10 micrograms/ml of gossypol could cause the most significant inhibition in these two cellular functions. The cell mitotic assay showed that in treated groups, the cell number of S phase was decreased from 43 to 31%, this fact indicated that the inhibition on cell proliferation caused by gossypol might be due to preventing cells to enter S phase. Besides, inhibition effect on the proliferation of prostatic epithelial cells was dosage dependent and related to the duration of treatment.